Gastrointestinal Tract Disorders in Diabetes Mellitus

2015 ◽  
pp. 185-193
Author(s):  
Akio Nagasaki ◽  
Chiyuki Nakanome ◽  
Nobuyuki Imai ◽  
Kunihiko Suzuki ◽  
Michio Hongo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gastrointestinal Tract

scholarly journals Efficacy of Prokinetic Itopride in Type 2 Diabetes Mellitus

2020 ◽  
pp. 35-39
Author(s):  
A. E. Shklyaev ◽  
D. D. Kazarin ◽  
Y. V. Gorbunov
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gastrointestinal Tract ◽  
Chronic Gastritis ◽  
Motor Dysfunction ◽  
Upper Gastrointestinal Tract ◽  
Itopride Hydrochloride ◽  
Upper Gastrointestinal

The constant increase in the incidence of diabetes in the world and the high frequency of lesions of the upper gastrointestinal tract with impaired motor function in this category of patients, on the one hand, worsen the clinical picture, and on the other, reduce the effectiveness of sugar-lowering therapy. Currently, specialists have at their disposal a number of prokinetics that contribute to the restoration of the motor-evacuation function of the stomach, but many of them have many undesirable effects. The aim of our study was to evaluate the effectiveness of itopride hydrochloride in the treatment of patients with chronic gastritis associated with Helicobacter pylori and type 2 diabetes. During the study, both general clinical and more specific research methods were used, in particular, esophagogastroduodenoscopy. According to the results of the study, the use of prokinetics in the treatment of patients with type 2 diabetes mellitus reduces the manifestations of impaired motor-evacuation function of the upper gastrointestinal tract. The results obtained indicate to verify the manifestations of chronic gastritis in patients with type 2 diabetes mellitus and the identification of motor dysfunction and the need for prokinetic therapy.

Impaired contractility and biomechanical remodeling of the upper gastrointestinal tract in diabetes mellitus

2006 ◽  
Vol 40 (Supplement 4) ◽  
pp. S198
Author(s):  
Jens Br??ndum Fr??kj??r ◽  
S??ren Due Andersen ◽  
Niels Ejskj??r ◽  
Peter Funch-Jensen ◽  
Asbj??rn Mohr Drewes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gastrointestinal Tract ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal

Role of glucagon in intestinal hyperemia associated with early experimental diabetes mellitus

1988 ◽  
Vol 255 (5) ◽  
pp. G542-G546
Author(s):  
L. F. Yrle ◽  
J. K. Smith ◽  
J. N. Benoit ◽  
D. N. Granger ◽  
R. J. Korthuis
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Gastrointestinal Tract ◽  
Experimental Diabetes ◽  
Reference Sample ◽  
Diabetic Rats ◽  
Experimental Diabetes Mellitus ◽  
Blood Flows ◽  
Sample Technique

The role of glucagon as a blood-borne mediator of the intestinal hyperemia associated with experimental diabetes mellitus was assessed in anesthetized fasted (18-24 h) rats 4 wk after the administration of streptozotocin (65 mg/kg body wt) or its vehicle. Selective removal of pancreatic glucagon from the circulation was accomplished by the intravenous administration of a highly specific glucagon antiserum. Blood flow to the gastrointestinal tract and kidneys was measured with radioactive microspheres using the reference sample technique. Blood flows were increased by at least 60% in each segment of the gastrointestinal tract of diabetic animals compared with control rats. Glucagon antiserum had no effect on blood flows in the gastrointestinal tract of control animals. However, the antiserum produced a significant reduction in blood flow to the stomach (26%), duodenum (25%), jejunum (12%), and kidneys (16%) in diabetic rats. There was no change in blood flow to the ileum or colon of diabetic animals with antiserum administration. The results of this study support the hypothesis that glucagon mediates a portion of the hyperemia noted in the stomach, duodenum, and jejunum. However, glucagon does not appear to play a role in the genesis of the hyperemia noted in more distal segments of the gastrointestinal tract (ileum and colon). A possible role for glucagon in the maintenance of renal blood flow in diabetic rats is suggested.

scholarly journals Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus

2010 ◽  
Vol 6 (2) ◽  
pp. 102-109 ◽  
Author(s):  
Francesco Rubino ◽  
Sarah L. R'bibo ◽  
Federica del Genio ◽  
Madhu Mazumdar ◽  
Timothy E. McGraw
Keyword(s):  
Diabetes Mellitus ◽  
Gastrointestinal Tract ◽  
Metabolic Surgery

scholarly journals Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Muhammad U. Sohail ◽  
Asmaa Althani ◽  
Haseeb Anwar ◽  
Roberto Rizzi ◽  
Hany E. Marei
Keyword(s):  
Diabetes Mellitus ◽  
Gastrointestinal Tract ◽  
Ethnic Origin ◽  
Intestinal Wall ◽  
Low Grade ◽  
Microbial Dysbiosis ◽  
Fermentation Profile ◽  
Low Grade Inflammation ◽  
Gut Fermentation

The incidence of diabetes mellitus is rapidly increasing throughout the world. Although the exact cause of the disease is not fully clear, perhaps, genetics, ethnic origin, obesity, age, and lifestyle are considered as few of many contributory factors for the disease pathogenesis. In recent years, the disease progression is particularly linked with functional and taxonomic alterations in the gastrointestinal tract microbiome. A change in microbial diversity, referred as microbial dysbiosis, alters the gut fermentation profile and intestinal wall integrity and causes metabolic endotoxemia, low-grade inflammation, autoimmunity, and other affiliated metabolic disorders. This article aims to summarize the role of the gut microbiome in the pathogenesis of diabetes. Additionally, we summarize gut microbial dysbiosis in preclinical and clinical diabetes cases reported in literature in the recent years.

scholarly journals Pyometra Perforation Caused byActinomyceswithout Intrauterine Device Involvement

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Hideharu Hagiya
Keyword(s):  
Diabetes Mellitus ◽  
Gastrointestinal Tract ◽  
Daily Activity ◽  
Intrauterine Device ◽  
Foreign Materials ◽  
Almost All

An 86-year-old woman with diabetes mellitus and severe decubitus at the sacral and calcaneal regions stemming from poor daily activity was diagnosed with pyometra perforation caused byActinomyces. No foreign materials, including an IUD, were found inside the uterus. Pyometra is usually caused by Enterobacteriaceae or anaerobes derived from the gastrointestinal tract. The virulence ofActinomycesis rather low, and, in almost all the reported cases ofActinomyces-related pyometra, an intrauterine device (IUD) was involved. Although rare,Actinomycesmay be ascribed as a virulent pathogen that causes pyometra in the absence of foreign materials.

Sign in / Sign up

Export Citation Format

Share Document