NKB1: A Killer Cell Inhibitory Receptor for Class I HLA-B Allotypes

2015 ◽  
pp. 104-115
Author(s):  
Annalisa D�Andrea ◽  
Lewis L. Lanier
Keyword(s):  
Killer Cell ◽  
Class I ◽  
Inhibitory Receptor ◽  
Killer Cell Inhibitory Receptor

The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

1997 ◽  
Vol 27 (2) ◽  
pp. 563-567 ◽  
Author(s):  
Marta Carretero ◽  
Claudia Cantoni ◽  
Teresa Bellón ◽  
Cristina Bottino ◽  
Roberto Biassoni ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Hla Class I ◽  
Class I ◽  
Inhibitory Receptor ◽  
Hla Class I Molecules ◽  
Killer Cell Inhibitory Receptor

Killer cell inhibitory receptor interactions with HLA class I molecules

1997 ◽  
Vol 52 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Neil T. Young ◽  
Mike Bunce ◽  
Peter J. Morris ◽  
Ken I. Welsh
Keyword(s):  
Killer Cell ◽  
Hla Class I ◽  
Class I ◽  
Inhibitory Receptor ◽  
Hla Class I Molecules ◽  
Receptor Interactions ◽  
Killer Cell Inhibitory Receptor

scholarly journals The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity

1997 ◽  
Vol 185 (8) ◽  
pp. 1523-1528 ◽  
Author(s):  
Sumati Rajagopalan ◽  
Eric O. Long
Keyword(s):  
Nk Cell ◽  
Killer Cell ◽  
Direct Interaction ◽  
Surface Expression ◽  
Structural Features ◽  
Class I ◽  
Inhibitory Receptor ◽  
Direct Binding ◽  
Cell Inhibition ◽  
Killer Cell Inhibitory Receptor

Natural killer (NK) cells in mice and humans express a number of structurally diverse receptors that inhibit target cell lysis upon recognition of major histocompatibility complex (MHC) class I molecules expressed on targets. The contribution of peptide to the structural features of class I required for NK cell inhibition appears to vary depending on the type of receptor engaged. Thus, while there is no peptide specificity in NK inhibition mediated by Ly-49A in the mouse, human histocompatibility antigen (HLA)-B*2705–specific NK clones displayed selectivity for peptides. In this report, we examine the role of peptide in the recognition of HLA-C by the defined killer cell inhibitory receptor (KIR) cl42 with established specificity for HLA-Cw4. Binding of soluble KIR cl42 molecules to HLA-Cw4 expressed on transporter associated with antigen presentation (TAP)-deficient RMA-S cells occurred only upon exogenous peptide loading. Moreover, there was peptide selectivity in that certain substitutions at positions 7 and 8 of the nonamer peptide QYDDAVYKL abolished Cw4 interaction with KIR cl42 despite similar surface expression of HLA-C. The specificity of this direct interaction between peptideloaded HLA-Cw4 on RMA-S cells and soluble KIR cl42 correlated with recognition by NK clones in that they were inhibited only by HLA-Cw4 loaded with the appropriate peptides.

Specificity of two anti-class IHLA monoclonal antibodies that block class I recognition by the NKB1 killer cell inhibitory receptor

1996 ◽  
Vol 48 (4) ◽  
pp. 278-284 ◽  
Author(s):  
J. E. Gumperz ◽  
J. C. M. Paterson ◽  
V. Litwin ◽  
N. Valiante ◽  
L. L. Lanier ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Killer Cell ◽  
Class I ◽  
Inhibitory Receptor ◽  
Killer Cell Inhibitory Receptor

scholarly journals Effective refolding of MHC class I molecule(Cw7)and killer cell inhibitory receptor(KIR2DL2)and their interaction

2001 ◽  
Vol 41 (supplement) ◽  
pp. S47
Author(s):  
S. Goda ◽  
A. Yokota ◽  
M. Shiroishi ◽  
K. Tsumoto ◽  
K. Maenaka ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Killer Cell ◽  
Class I ◽  
Inhibitory Receptor ◽  
Mhc Class I Molecule ◽  
Killer Cell Inhibitory Receptor

Crystallization and preliminary diffraction studies of the extracellular region of human p58 killer cell inhibitory receptor (KIR2)

1998 ◽  
Vol 54 (3) ◽  
pp. 433-435 ◽  
Author(s):  
Katsumi Maenaka ◽  
Takeo Juji ◽  
Kenji Tadokoro ◽  
Karl Harlos ◽  
David I. Stuart ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Killer Cell ◽  
Hla Class I ◽  
Immunoglobulin Superfamily ◽  
Diffusion Method ◽  
Inhibitory Receptor ◽  
Data Set ◽  
Extracellular Region ◽  
Hla Class I Molecules ◽  
Killer Cell Inhibitory Receptor

Molecules of the human killer cell inhibitory receptor (KIR) family, which belong to the immunoglobulin superfamily (IgSF), are expressed on the surface of natural killer (NK) cells and some subsets of T cells. These receptors function to mediate the inhibition or activation of cytotoxic activity by recognizing HLA class I molecules on the target cell. The extracellular region of a p58 KIR specific for HLA-Cw1,3,7 (KIR2) has been overproduced in Escherichia coli and purified. The recombinant KIR2 has been crystallized in 9–10% poly(ethylene glycol) methyl ether (average Mr = 8000), 50mM HEPES, 8% ethylene glycol, 0.5% octyl-β-glucoside, pH 7.5, at 294 K using the sitting-drop vapour-diffusion method. Preliminary X-ray diffraction studies reveal the space group to be hexagonal (P6122 or P6522) with lattice constants a = b = 95.3, c = 130.8 Å. A native data set (3 Å resolution) has been collected at the Photon Factory (λ = 1.0 Å).

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