Investigation of the Etiology of Central Serous Chorioretinopathy Using En-Face Optical Coherence Tomography and Indocyanine Green Angiography

2016 ◽  
Vol 236 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Ari Shinojima ◽  
Kyoko Fujita ◽  
Ryusaburo Mori ◽  
Akiyuki Kawamura ◽  
Mitsuko Yuzawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Central Serous Chorioretinopathy ◽  
Indocyanine Green Angiography ◽  
Late Phase ◽  
Optical Coherence ◽  
Swept Source ◽  
Face Images ◽  
En Face ◽  
Swept Source Oct

Purpose: To identify locations of hypofluorescent lesions on late-phase indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC) using en-face optical coherence tomography (OCT). Procedures: We retrospectively studied 25 consecutive untreated CSC patients, using swept-source OCT and ICGA. En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM). We compared the sizes of hyperreflective areas in the 25 CSC and 25 contralateral eyes on en-face images and hypofluorescent areas on ICGA after 30 min. Results: All 25 CSC eyes and 13 contralateral eyes showed abnormal hypofluorescent areas on late-phase ICGA and hyperreflective areas on en-face OCT from BrM to the choriocapillaris, and these findings correlated with the abnormal areas (r = 0.9988; p < 0.001). Conclusions: In CSC patients, we detected abnormal hypofluorescence on ICGA in the late phase, which corresponded to abnormal hyperreflective areas from BrM to the choriocapillaris level in en-face images.

scholarly journals Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography

2020 ◽  
Author(s):  
Syunsuke Araki ◽  
Atsushi Miki ◽  
Katsutoshi Goto ◽  
Tsutomu Yamashita ◽  
Tsuyoshi Yoneda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Normal Control ◽  
Structural Changes ◽  
Vascular Density ◽  
Optical Coherence ◽  
Swept Source ◽  
3 Dimensional ◽  
Face Images ◽  
En Face ◽  
Normal Controls

Abstract Background Structural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia.Methods This study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller's layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch's membrane. The analysis area was a 3×3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes.Results Mean CVD was 59.11 ± 0.66% in amblyopic eyes, 59.23 ± 0.81% in fellow eyes, and 59.29 ± 0.74% in normal control eyes. CVD showed a significant positive relationship with SFCT (p=0.004), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p=0.502).Conclusions CVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller's layer is unaffected in unilateral hyperopic amblyopic eyes.

scholarly journals Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Syunsuke Araki ◽  
Atsushi Miki ◽  
Katsutoshi Goto ◽  
Tsutomu Yamashita ◽  
Tsuyoshi Yoneda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Normal Control ◽  
Structural Changes ◽  
Vascular Density ◽  
Optical Coherence ◽  
Swept Source ◽  
3 Dimensional ◽  
Face Images ◽  
En Face ◽  
Normal Controls

Abstract Background Structural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia. Methods This study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller’s layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch’s membrane. The analysis area was a 3 × 3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes. Results Mean CVD was 59.11 ± 0.66% in amblyopic eyes, 59.23 ± 0.81% in fellow eyes, and 59.29 ± 0.74% in normal control eyes. CVD showed a significant positive relationship with SFCT (p = 0.004), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p = 0.502). Conclusions CVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller’s layer is unaffected in unilateral hyperopic amblyopic eyes.

scholarly journals Tethered capsule en face optical coherence tomography for imaging Barrett’s oesophagus in unsedated patients

2020 ◽  
Vol 7 (1) ◽  
pp. e000444
Author(s):  
Kaicheng Liang ◽  
Osman O Ahsen ◽  
Annalee Murphy ◽  
Jason Zhang ◽  
Tan H Nguyen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Lower Oesophageal Sphincter ◽  
Barrett’S Oesophagus ◽  
Optical Coherence ◽  
Sampling Errors ◽  
Cross Sectional ◽  
Swept Source ◽  
Barrett's Oesophagus ◽  
Face Images ◽  
En Face

ObjectiveBarrett’s oesophagus (BE) screening outside the endoscopy suite can identify patients for surveillance and reduce mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image oesophageal mucosa in unsedated patients and detect features of BE. We investigated ultrahigh-speed tethered capsule swept-source OCT (SS-OCT), improved device design, developed procedural techniques and measured capsule contact, longitudinal pullback non-uniformity and patient toleration.DesignOCT was performed in 16 patients prior to endoscopic surveillance/treatment. Unsedated patients swallowed the capsule with sips of water and the tether was pulled back to image the oesophagus. SS-OCT at 1 000 000 A-scans/s enabled imaging 10 cm oesophageal lengths in 10 s with 30 µm transverse and 8 µm axial resolution. Capsule contact, longitudinal image coverage and patient toleration were assessed.ResultsNine patients had non-dysplastic BE, three had ablative treatment-naïve neoplasia and four had prior ablation for dysplasia. Dry swallows facilitated capsule transit through the lower oesophageal sphincter (LES), and waiting 10 s before pullback reduced swallow induced LES relaxation. Slow nasal inhalation facilitated capsule retrieval and minimised gag reflex. The procedure was well tolerated. Ultrahigh-speed SS-OCT generated cross-sectional and subsurface en face images showing BE features, while subsurface en face images were required to assess the gastro-oesophageal junction. Candidate features of dysplasia were also identified which could inform follow-up endoscopy/biopsy. BE features were seen in all patients with histologically confirmed BE. Mean capsule contact over BE was 75%±27% for all patients and better in short segment BE. Mean longitudinal image coverage over BE was 59%±34% and better for long segment BE.ConclusionsUltrahigh-speed tethered capsule SS-OCT can image en face and cross-sectional mucosal features over wide areas. Device and procedure optimisation improved performance. BE features could be identified in all patients, but limited capsule contact and longitudinal coverage could cause sampling errors for focal pathologies.

scholarly journals En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy

Ophthalmology ◽  
2014 ◽  
Vol 121 (3) ◽  
pp. 719-726 ◽  
Author(s):  
Daniela Ferrara ◽  
Kathrin J. Mohler ◽  
Nadia Waheed ◽  
Mehreen Adhi ◽  
Jonathan J. Liu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Central Serous Chorioretinopathy ◽  
Optical Coherence ◽  
Chronic Central Serous Chorioretinopathy ◽  
Swept Source ◽  
En Face

scholarly journals Optical coherence tomography angiography for the detection of macular neovascularization—comparison of en face versus cross-sectional view

Eye ◽  
2022 ◽  
Author(s):  
Robert Siggel ◽  
Christel Spital ◽  
Anna Lentzsch ◽  
Sandra Liakopoulos
Keyword(s):  
Optical Coherence Tomography ◽  
Sensitivity And Specificity ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Face Images ◽  
En Face ◽  
En Face Imaging ◽  
Subretinal Hyperreflective Material

Abstract Purpose To evaluate sensitivity and specificity of swept source-optical coherence tomography angiography (SS-OCTA) en face images versus cross-sectional OCTA versus a combination of both for the detection of macular neovascularization (MNV). Design Prospective cohort study. Participants Consecutive patients with various chorioretinal diseases and subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye. Methods 102 eyes of 63 patients with fluorescein angiography (FA), OCT and SS-OCTA performed on the same day were included. FA images, the outer retina to choriocapillaris (ORCC) OCTA en face slab, a manually modified en face slab (‘custom slab’), cross-sectional OCTA and a combination of OCTA en face and cross-section were evaluated for presence of MNV. Main outcome measures Sensitivity and specificity for MNV detection, as well as the concordance was calculated using FA as the reference. Results OCTA en face imaging alone yielded a sensitivity of 46.3% (automated)/78.1% (custom) and specificity of 93.4% (automated)/88.5% (custom) for MNV detection. Cross-sectional OCTA (combination with en face) resulted in a sensitivity of 85.4% (82.9%) and specificity of 82.0% (85.3%). Concordance to FA was moderate for automated en face OCTA (κ = 0.43), and substantial for custom en face OCTA (κ = 0.67), cross-sectional OCTA (κ = 0.66) and the combination (κ = 0.68). Conclusion Segmentation errors result in decreased sensitivity for MNV detection on automatically generated OCTA en face images. Cross-sectional OCTA allows detection of MNV without manual modification of segmentation lines and should be used for evaluation of MNV on OCTA.

Sign in / Sign up

Export Citation Format

Share Document