Acetazolamide Reduces Retinal Inner Nuclear Layer Thickness in Microcystic Macular Edema Secondary to Optic Neuropathy

2018 ◽  
Vol 79 (3-4) ◽  
pp. 150-153
Author(s):  
François-Xavier Borruat ◽  
Muriel Dysli ◽  
Nathalie Voide ◽  
Mathias Abegg
Keyword(s):  
Macular Edema ◽  
Layer Thickness ◽  
Optic Neuropathy ◽  
Visual Function ◽  
Case Series ◽  
Inner Nuclear Layer ◽  
Retinal Layer ◽  
Segmentation Of Images ◽  
Cellular Water ◽  
Cellular Water Transport

Optic neuropathy (ON) is commonly complicated by microcystic macular edema (MME), that is, small vertical cystoid spaces in the inner nuclear layer (INL) of the macula. We performed a retrospective consecutive case series of 14 eyes from 11 patients with ON and MME that were treated with oral acetazolamide, acting on cellular water transport. Contralateral eyes without MME were used as controls. Segmentation of images obtained with OCT was used to determine changes of individual retinal layer thickness during treatment. Retinal INL thickness consistently decreased in all eyes after 2–3 weeks of treatment. Recurrence of MME was observed after treatment cessation. No significant change of retinal thickness was found in contralateral unaffected eyes. Visual function did not change with treatment. Acetazolamide significantly improved the MME in eyes with ON. However, visual function did not. Acetazolamide is a treatment option for MME associated with ON but without an impact on the visual function.

scholarly journals Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
LakshmiPriya Rangaraju ◽  
Xuejuan Jiang ◽  
J. Jason McAnany ◽  
Michael R. Tan ◽  
Justin Wanek ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Layer Thickness ◽  
Pigment Epithelium ◽  
Outer Nuclear Layer ◽  
Retinal Pigment ◽  
Plexiform Layer ◽  
Retinal Layer ◽  
Inner Plexiform Layer ◽  
Retinal Microvasculature

Purpose. Diabetes is known to cause alterations in retinal microvasculature and tissue that progressively lead to visual impairment. Optical coherence tomography (OCT) is useful for assessment of total retinal thickening due to diabetic macular edema (DME). In the current study, we determined associations between visual acuity (VA) and retinal layer thickness, reflectance, and interface disruption derived from enface OCT images in subjects with and without DME. Materials and Methods. Best corrected VA was measured and high-density OCT volume scans were acquired in 149 diabetic subjects. A previously established image segmentation method identified retinal layer interfaces and locations of visually indiscernible (disrupted) interfaces. Enface thickness maps and reflectance images of the nerve fiber layer (NFL), combined ganglion cell and inner plexiform layer (GCLIPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor outer segment layer (OSL), and retinal pigment epithelium (RPE) were generated in the central macular subfield. The associations among VA and retinal layer metrics were determined by multivariate linear regressions after adjusting for covariates (age, sex, race, HbA1c, diabetes type, and duration) and correcting for multiple comparisons. Results. In DME subjects, increased GCLIPL and OPL thickness and decreased OSL thickness were associated with reduced VA. Furthermore, increased NFL reflectance and decreased OSL reflectance were associated with reduced VA. Additionally, increased areas of INL and ONL interface disruptions were associated with reduced VA. In subjects without DME, increased INL thickness was associated with reduced VA, whereas in subjects without DME but with previous antivascular endothelium growth factor treatment, thickening of OPL was associated with reduced VA. Conclusions. Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME.

scholarly journals Ranibizumab for Macular Edema Secondary to Central and Branch Retinal Vein Occlusion in Patients Younger Than 50 Years of Age

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Maurizio Battaglia Parodi ◽  
Francesco Romano ◽  
Alessandro Arrigo ◽  
Stefano Mercuri ◽  
Alessandro Franceschi ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Therapeutic Option ◽  
Case Series ◽  
Subretinal Fluid ◽  
Retinal Layer ◽  
Foveal Thickness ◽  
Vein Occlusion

Background. To determine the effectiveness of intravitreal ranibizumab (IVR) approach over 1-year follow-up in patients younger than 50 years old with central and branch retinal vein occlusion (RVO) complicated by macular edema (ME). Methods. Prospective, open-label case series. Patients initiating IVR injections from January 2015 to May 2017 were consecutively recruited. Each patient underwent monthly ophthalmic examination and structural OCT over 12 months. A single IVR injection was administered at baseline, followed by a PRN regimen. Outcome measures are best-corrected visual acuity (BCVA); central foveal thickness (CFT); number of IVR injections; subretinal fluid (SRF); epiretinal membrane; and outer retinal layer (ORL) status. Results. Thirty-eight patients (27 males) were included in the study. At follow-up, mean BCVA improved from 0.40±0.17 to 0.10±0.10 LogMAR in patients with central RVO and from 0.39±0.19 to 0.19±0.07 LogMAR in those with branch RVO, with 20 eyes gaining ≥3 ETDRS lines. In addition, mean CFT significantly decreased in both subgroups at the end of follow-up. All patients with SRF at baseline (9) disclosed complete resolution after 1 year. Likewise, ORL appeared reconstituted in most cases. At 12 months, 3.6±2.4 and 4.4±2.4 IVR injections were required for central and branch RVO, respectively, with only 5 eyes showing ME persistence. Conclusions. Our study indicates that IVR injections can be a valid therapeutic option in patients under 50 years of age with ME secondary to RVO.

Comparison of Retinal Layer Thickness in Eyes with Resolved Diabetic Macular Edema Receiving Ranibizumab with Normal Eyes

2019 ◽  
Vol 243 (1) ◽  
pp. 27-36
Author(s):  
Zubir S. Rentiya ◽  
Saleema Kherani ◽  
Bushra Usmani ◽  
Manneha A. Qazi ◽  
Mohammad Ali Sadiq ◽  
...  
Keyword(s):  
Macular Edema ◽  
Layer Thickness ◽  
Diabetic Macular Edema ◽  
Retinal Layer

scholarly journals Effectiveness of a Hydrophilic Curcumin-Based Formulation in Coadjuvating the Therapeutic Effect of Intravitreal Dexamethasone in Subjects With Diabetic Macular Edema

2022 ◽  
Vol 12 ◽  
Author(s):  
Mariacristina Parravano ◽  
Davide Allegrini ◽  
Adriano Carnevali ◽  
Eliana Costanzo ◽  
Giuseppe Giannaccare ◽  
...  
Keyword(s):  
Macular Edema ◽  
Layer Thickness ◽  
Diabetic Macular Edema ◽  
Therapy Group ◽  
Combined Therapy ◽  
Combination Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Retinal Layer ◽  
The Mean

Purpose: This study evaluates if the addition of a curcumin formulation with a polyvinylpyrrolidone-hydrophilic carrier (CHC; Diabec®, Alfa Intes, Italy) to intravitreal injections of dexamethasone (DEX-IVT) can affect the morphological retinal characteristics, extending the steroid re-treatment period in patients with diabetic macular edema (DME).Methods: A randomized controlled clinical trial was carried out in DME patients, randomly assigned to receive DEX-IVT or DEX-IVT and a CHC. The evaluation of the mean difference of central retinal thickness (CRT) was the primary aim. Secondary aims were the evaluations of best-corrected visual acuity, differences in the predetermined retinal layer thickness, the number/time of re-treatment, and the assessment of safety.Results: A total of 73 DME patients were included (35 in the control group and 38 in the combined therapy group). In both the control and combined therapy groups, the mean CRT change from T0 to the 6 months’ evaluation was significant (p = 0.00). The mean CRT result was significantly different at month 4 (p = 0.01) between the control and combined therapy groups, with a greater reduction in the combined therapy group, in particular, in patients with ≤10 years of diabetes. A trend of CRT reduction in the combined therapy group has been observed also considering patients with subfoveal neuroretinal detachment. In addition, we observed that the reduction of inner retinal layer thickness was greater in the combination group, in comparison with controls.Conclusion: The combination of a CHC to DEX-IVT is a promising therapeutic option in case of DME, in particular, for patients with early-stage diabetes and with an inflammatory phenotype. Further studies will be necessary to confirm these findings.

OUTER RETINAL LAYER THICKNESS AS GOOD VISUAL PREDICTOR IN PATIENTS WITH DIABETIC MACULAR EDEMA

Retina ◽  
2018 ◽  
Vol 38 (4) ◽  
pp. 805-811 ◽  
Author(s):  
Tamer F. Eliwa ◽  
Mahdi A. Hussein ◽  
Mohamed A. Zaki ◽  
Osama A. Raslan
Keyword(s):  
Macular Edema ◽  
Layer Thickness ◽  
Diabetic Macular Edema ◽  
Retinal Layer

The effect of outer retinal layer thickness on visual acuity in retinal vein occlusion after resolution of macular edema

2021 ◽  
Vol 30 (3) ◽  
pp. 233
Author(s):  
Berrak Şekeryapan Gediz ◽  
Yasemin Özdamar Erol ◽  
Sibel Doğuizi ◽  
Büşra Dilara Yıldırım Erdal ◽  
Müge Pınar Çakar Özdal
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Layer Thickness ◽  
Retinal Vein Occlusion ◽  
Retinal Layer ◽  
Vein Occlusion

scholarly journals Correlation of retinal layer changes with vision gain in diabetic macular edema during conbercept treatment

2019 ◽  
Author(s):  
Yupeng Xu ◽  
Yuan Qu ◽  
Yan Suo ◽  
Jian Gao ◽  
Xia Chen ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Layer Thickness ◽  
Diabetic Macular Edema ◽  
Outer Nuclear Layer ◽  
Plexiform Layer ◽  
Retinal Layer ◽  
Central Field ◽  
Inner Plexiform Layer ◽  
Sd Oct

Abstract Backgrounds: To assess the changes in individual retinal layer thickness and visual function associated with gains in visual acuity after an intravitreal conbercept injection in the diabetic macular edema (DME) on spectral domain optical coherence tomography (SD-OCT) and microperimetry during 1-year follow-up. Methods: Retrospective observational study. Twenty patients with clinically significant DME in the study eye were imaged by SD-OCT every three months and MP1 microperimeter in the third month while receiving anti-vascular endothelial growth factor (VEGF) (conbercept) treatment. In each patient, seven retinal layers were segmented in 98 scans covering a 6mm×6mm area of the macula at baseline and during 1 year of treatment. An automatic, full-threshold microperimetry of the central field (10°×10°, 40 stimulated points) with the MP1 microperimeter. Thickness and microperimetry changes were quantitatively measured and evaluated for their correlation with increases in visual acuity. Results: Although thicknesses of the inner nuclear layer (INL) and the outer nuclear layer (ONL) were reduced the most after treatment (p< 0.05), decreases of the ganglion cell layer (GCL) (r = 0.591, p= 0.006) and inner plexiform layer (IPL) (r= 0.663, p= 0.001) in central subfield area was associated with best-corrected visual acuity (BCVA) gain, and had the best estimation of BCVA gain (adjust R2=0.544). Mean macular sensitivity in the central subfield was also well correlated with BCVA gain (r=0.531, p=0.016). Conclusions: Whereas the largest decrease of layer thickness occurred in the INL and ONL, the decreases in GCL and IPL were more associated with gains in vision and improved microperimetry. The decrease of the GCL and IPL might suggest that neural recovery occurred after the resolution of edema during conbercept treatment. Keywords: Diabetic macular edema, retinal layer thickness, layer segmentation, anti-VEGF, Conbercept.

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