Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats

Pharmacology ◽  
2019 ◽  
Vol 105 (9-10) ◽  
pp. 514-521
Author(s):  
Xiao Zhang ◽  
Chunqin Chu ◽  
Chengtai Ma ◽  
Jian Sun ◽  
Zhenfang Liu
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Nerve ◽  
Analgesic Effect ◽  
Nerve Conduction Velocity ◽  
Compound Muscle Action Potential ◽  
Nerve Compression ◽  
Muscle Action ◽  
Withdrawal Threshold ◽  
Muscle Action Potential ◽  
Rat Peripheral Nerve

To explore the analgesic effect of dizocine combined with ropivacaine on recurrent neuropathic pain in rat model of peripheral nerve compression. Rats were randomly divided into 5 groups: sham control group (S), peripheral nerve compression model group (M), dizocine group (D), ropivacaine group (R), and combined drug group (DR). Rat peripheral nerve compression model was constructed to observe the symptoms of the rats before and after surgery. Mechanical withdrawal threshold was measured on the 21st day after surgery. The electrophysiological changes of rat peripheral nerve were measured by biopotential recording system, including proximal latency, distal latency, and compound muscle action potential. The incubation period and nerve conduction velocity were further obtained. Histological changes were observed by HE staining and toluidine blue staining. Axon number and myelin damage grade were performed, and the ultrastructure was observed by transmission electron microscopy (TEM). The mechanical withdrawal threshold, nerve conduction velocity, and compound muscle action potential were effectively increased in combination group. However, the proximal latency, distal latency, and incubation period were significantly reduced. Furthermore, dizocine combined with ropivacaine can effectively reduce the degree of myelination. TEM shown that the DR group had the best therapeutic effect, and the histological appearance of the cross section was quite similar to that of the S group. Dizocine combined with ropivacaine has a significant analgesic effect in rat model of peripheral nerve compression.

Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

2019 ◽  
Vol 18 (04) ◽  
pp. 182-184
Author(s):  
Roshan Koul ◽  
Saleem Saleh Naiha Al Harousi ◽  
Sousan AlNabhani ◽  
Amna AlFutaisi
Keyword(s):  
Retrospective Study ◽  
Action Potential ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Compound Muscle Action Potential ◽  
University Hospital ◽  
Muscle Action ◽  
Sultan Qaboos University ◽  
Muscle Action Potential ◽  
Vincristine Neuropathy

Abstract Objective The main objective of this article was to evaluate vincristine neuropathy effect on common peroneal and tibial nerves. Methods A retrospective study was conducted in children with vincristine neuropathy between August 2006 and January 2016 at Sultan Qaboos University Hospital. Results Twenty-eight children (15 females and 13 males) were included in the study. The compound muscle action potential of common peroneal nerves was significantly reduced relative to the tibial nerves (p < 0.05)). There was no difference in latency and nerve conduction velocity between the two nerves. Conclusion Children receiving vincristine demonstrate severe peroneal neuropathy compared with tibial nerves. We conclude that squatting posture effects peroneal nerves and postulate that the peroneal nerves are affected more due to the squatting posture. This squatting posture stretches the nerves that are already affected by the toxic effect of vincristine.

Age-Related Change in Peripheral Nerve Conduction: Compound Muscle Action Potential Duration and Dispersion

Gerontology ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Katsumi Kurokawa ◽  
Yasuyo Mimori ◽  
Eiji Tanaka ◽  
Tatsuo Kohriyama ◽  
Shigenobu Nakamura
Keyword(s):  
Action Potential ◽  
Peripheral Nerve ◽  
Nerve Conduction ◽  
Action Potential Duration ◽  
Compound Muscle Action Potential ◽  
Muscle Action ◽  
Age Related ◽  
Muscle Action Potential

scholarly journals Surgery of True Recurring Median Carpal Tunnel Syndrome with Synovial Flap by Wulle Plus Integument Enlargement Leads to a High Patient’s Satisfaction and Improved Functionality

2019 ◽  
Vol 8 (12) ◽  
pp. 2094
Author(s):  
Stephan Payr ◽  
Thomas M. Tiefenboeck ◽  
Veith Moser ◽  
Edvin Turkof
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Nerve Conduction Velocity ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Muscle Action ◽  
Patient’S Satisfaction ◽  
Muscle Action Potential ◽  
Tunnel Syndrome ◽  
Tissue Flap

This prospective study was conducted to investigate electrophysiological qualities and patient’s satisfaction of a synovial gliding tissue flap in treating true recurring carpal tunnel syndrome. In 14 patients (11 women, three men), 15 median nerves were included in this retrospective study. For all 15 nerves, motor and sensory nerve conduction velocity, compound muscle action potential, a Visual Analogue Scale-score (VAS-score) questionnaire and an adapted Levine-Test were evaluated pre- and postoperatively. All participants underwent operative neurolysis of the median nerve, which was then enwrapped by a synovial gliding tissue flap. Eleven procedures were completed by integument enlargement. Follow-up period was 12 months. Postoperatively, distal latency decreased significantly by 15.6%. Compound muscle action potential and sensory nerve conduction velocity did not improve significantly. VAS score regarding pain reduced highly significantly with 74.1%. The adapted Levine-Test function score improved highly significantly with 39.2%. The synovial gliding tissue flap lead to an excellent patient’s satisfaction for treating true recurring carpal tunnel syndrome. Primary wound closure should be completed with integument enlargement if needed.

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