A Meta-Analysis of Erectile Dysfunction and Alcohol Consumption

2021 ◽  
pp. 1-17
Author(s):  
Shen Li ◽  
Ju-Min Song ◽  
Ke Zhang ◽  
Chang-Le Zhang
Keyword(s):  
Erectile Dysfunction ◽  
Alcohol Consumption ◽  
Meta Analysis ◽  
Regression Analyses ◽  
High Alcohol ◽  
Dual Effect ◽  
Random Effects Models ◽  
High Alcohol Consumption ◽  
Stratified Analysis ◽  
Regular Alcohol Consumption

<b><i>Purpose:</i></b> The purpose of the study was to evaluate the association between alcohol consumption and risk of erectile dysfunction (ED). <b><i>Methods:</i></b> PubMed was searched for reports published before June 2019. Data were extracted and combined odds ratios (ORs) calculated with random-effects models. <b><i>Results:</i></b> Finally, 46 studies were included (216,461 participants). The results of our meta-analysis indicated that there was a significant association between regular alcohol consumption and ED (OR 0.89, 95% confidence interval [CI]: 0.81–0.97). There was no indication of publication bias (Egger’s test, <i>p</i> = 0.37). In the stratified analysis, the pooled OR of ED for light to moderate and high alcohol consumption was 0.82 (95% CI: 0.72–0.94) and 0.82 (95% CI: 0.67–1.00), respectively. No variable related to the source of heterogeneity was found in univariate and multivariate meta-regression analyses. A dose-response meta-analysis suggested that a nonlinear relationship between alcohol consumption and risk of ED was observed (<i>p</i> for nonlinearity &#x3c;0.001). <b><i>Conclusion:</i></b> A J-shaped relationship between alcohol consumption and risk of ED was observed. Alcohol should be taken in moderate quantities in order to obtain the dual effect of disinhibition and relaxation. If taken chronically, it could provoke vascular damages.

scholarly journals Functional validity, role, and implications of heavy alcohol consumption genetic loci

2020 ◽  
Vol 6 (3) ◽  
pp. eaay5034 ◽  
Author(s):  
Andrew Thompson ◽  
James Cook ◽  
Hélène Choquet ◽  
Eric Jorgenson ◽  
Jie Yin ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Disease Risk ◽  
Meta Analysis ◽  
Population Level ◽  
Model Organisms ◽  
High Alcohol ◽  
Genetic Loci ◽  
High Alcohol Consumption ◽  
Genome Wide ◽  
Heavy Alcohol Consumption

High alcohol consumption is a risk factor for morbidity and mortality, yet few genetic loci have been robustly associated with alcohol intake. Here, we use U.K. Biobank (n = 125,249) and GERA (n = 47,967) datasets to determine genetic factors associated with extreme population-level alcohol consumption and examine the functional validity of outcomes using model organisms and in silico techniques. We identified six loci attaining genome-wide significant association with alcohol consumption after meta-analysis and meeting our criteria for replication: ADH1B (lead SNP: rs1229984), KLB (rs13130794), BTF3P13 (rs144198753), GCKR (rs1260326), SLC39A8 (rs13107325), and DRD2 (rs11214609). A conserved role in phenotypic responses to alcohol was observed for all genetic targets available for investigation (ADH1B, GCKR, SLC39A8, and KLB) in Caenorhabditis elegans. Evidence of causal links to lung cancer, and shared genetic architecture with gout and hypertension was also found. These findings offer insight into genes, pathways, and relationships for disease risk associated with high alcohol consumption.

scholarly journals High alcohol consumption and the risk of renal damage: a systematic review and meta-analysis

QJM ◽  
2014 ◽  
Vol 108 (7) ◽  
pp. 539-548 ◽  
Author(s):  
W. Cheungpasitporn ◽  
C. Thongprayoon ◽  
W. Kittanamongkolchai ◽  
B.A. Brabec ◽  
O.A. O'Corragain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alcohol Consumption ◽  
Renal Damage ◽  
Meta Analysis ◽  
High Alcohol ◽  
High Alcohol Consumption

Innate gut microbiota predisposes to high alcohol consumption

2021 ◽  
Author(s):  
Fernando Ezquer ◽  
Maria Elena Quintanilla ◽  
Francisco Moya‐Flores ◽  
Paola Morales ◽  
José Manuel Munita ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
High Alcohol ◽  
High Alcohol Consumption

scholarly journals Association between alcohol consumption status and obesity-related comorbidities in men: data from the 2016 Korean community health survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo-Yeon Kim ◽  
Hyewon Nam ◽  
Jeong-Ju Yoo ◽  
Yoon-Young Cho ◽  
Dug-Hyun Choi ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Binge Drinking ◽  
Community Health ◽  
Health Survey ◽  
High Alcohol ◽  
High Alcohol Consumption ◽  
Community Health Survey ◽  
Alcoholic Drinks ◽  
Binge Drinkers ◽  
Obesity Hypertension

Abstract Background This study was performed to investigate the association between the amount of alcohol consumption or binge drinking and obesity-related comorbidities in Korean men. Methods A total of 103,048 men aged 19 years or older were investigated in the 2016 Korean Community Health Survey. The participants were divided into five groups according to the standard number of alcoholic drinks consumed per week. Results Of the total participants, 20.7% were in the high alcohol consumption group, consuming more than 28 drinks per week. After adjustment for clinical factors, high alcohol consumption was significantly associated with higher odds ratios (ORs) of obesity (OR, 1.449; 95% confidence interval [CI], 1.412 to 1.591; P < 0.0001), hypertension (OR, 1.76; 95% CI, 1.636 to 1.894; P < 0.0001), and dyslipidemia (OR, 1.356; 95% CI, 1.247 to 1.474; P < 0.0001). In contrast, mild to moderate alcohol consumption was associated with a lower risk of diabetes (OR, 0.799; 95% CI, 0.726 to 0.88; P = 0.0015) and high alcohol consumption was not associated with a higher risk of diabetes (OR, 0.945; 95% CI, 0.86 to 1.039; P = 0.0662). Among drinkers, except for social drinkers, binge drinking was significantly associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia. Conclusions High alcohol consumption was associated with higher risks of obesity, hypertension, and dyslipidemia in Korean men. In contrast, high consumption was not associated with a higher risk of diabetes. In particular, binge drinkers were associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia compared to non-binge drinkers.

scholarly journals Cancers due to smoking and high alcohol consumption

2018 ◽  
Author(s):  
Ute Mons ◽  
Thomas Gredner ◽  
Gundula Behrens ◽  
Christian Stock ◽  
Hermann Brenner
Keyword(s):  
Alcohol Consumption ◽  
High Alcohol ◽  
High Alcohol Consumption

scholarly journals Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health

2019 ◽  
Vol 50 (3) ◽  
pp. 484-498 ◽  
Author(s):  
Andries T. Marees ◽  
Dirk J. A. Smit ◽  
Jue-Sheng Ong ◽  
Stuart MacGregor ◽  
Jiyuan An ◽  
...  
Keyword(s):  
Mental Health ◽  
Substance Use ◽  
Alcohol Consumption ◽  
Genetic Correlations ◽  
High Alcohol ◽  
Genetic Associations ◽  
Potential Influence ◽  
High Alcohol Consumption ◽  
Genome Wide ◽  
Consumption Frequency

AbstractBackground. Frequency and quantity of alcohol consumption are metrics commonly used to measure alcohol consumption behaviors. Epidemiological studies indicate that these alcohol consumption measures are differentially associated with (mental) health outcomes and socioeconomic status (SES). The current study aims to elucidate to what extent genetic risk factors are shared between frequency and quantity of alcohol consumption, and how these alcohol consumption measures are genetically associated with four broad phenotypic categories: (i) SES; (ii) substance use disorders; (iii) other psychiatric disorders; and (iv) psychological/personality traits.Methods. Genome-Wide Association analyses were conducted to test genetic associations with alcohol consumption frequency (N = 438 308) and alcohol consumption quantity (N = 307 098 regular alcohol drinkers) within UK Biobank. For the other phenotypes, we used genome-wide association studies summary statistics. Genetic correlations (rg) between the alcohol measures and other phenotypes were estimated using LD score regression.Results. We found a substantial genetic correlation between the frequency and quantity of alcohol consumption (rg = 0.52). Nevertheless, both measures consistently showed opposite genetic correlations with SES traits, and many substance use, psychiatric, and psychological/personality traits. High alcohol consumption frequency was genetically associated with high SES and low risk of substance use disorders and other psychiatric disorders, whereas the opposite applies for high alcohol consumption quantity.Conclusions. Although the frequency and quantity of alcohol consumption show substantial genetic overlap, they consistently show opposite patterns of genetic associations with SES-related phenotypes. Future studies should carefully consider the potential influence of SES on the shared genetic etiology between alcohol and adverse (mental) health outcomes.

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