scholarly journals Understanding the treatment algorithm of patients with metastatic pancreatic neuroendocrine neoplasms: A single-institution retrospective analysis comparing outcomes of chemotherapy, molecular targeted therapy and peptide receptor radionuclide therapy in 255 patients

2020 ◽  
Author(s):  
Aimee R. Hayes ◽  
Ingrid Y.F Mak ◽  
Nicholas Evans ◽  
Rishi Naik ◽  
Alexander Crawford ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Retrospective Analysis ◽  
Radionuclide Therapy ◽  
Molecular Targeted Therapy ◽  
Treatment Algorithm ◽  
Peptide Receptor Radionuclide Therapy ◽  
Neuroendocrine Neoplasms ◽  
Single Institution ◽  
Pancreatic Neuroendocrine Neoplasms ◽  
Peptide Receptor

Severe metabolic acidosis and hyperkalemia after peptide receptor radionuclide therapy. A case report, review of the literature and proposed treatment algorithm

2021 ◽  
pp. 239936932110197
Author(s):  
Nikolaos A Trikalinos ◽  
Hyun Kim ◽  
Amir Iravani ◽  
Lauren Henke ◽  
Anitha Vijayan
Keyword(s):  
Radionuclide Therapy ◽  
Treatment Algorithm ◽  
Peptide Receptor Radionuclide Therapy ◽  
Neuroendocrine Neoplasms ◽  
Review Of The Literature ◽  
Peptide Receptor ◽  
Life Threatening ◽  
Well Differentiated ◽  
Intravenous Sodium ◽  
Electrolyte Abnormalities

Peptide receptor radionuclide therapy (PRRT) has been increasingly used in the treatment of patients with well-differentiated neuroendocrine neoplasms (WD-NENs), but electrolyte abnormalities during prophylactic aminoacid (AA) infusion can complicate its administration. We describe a case of AA-induced acidosis and hyperkalemia associated with PRRT. We tailored an oral and intravenous sodium bicarbonate regimen for pre-emptive treatment prior to subsequent PRRT session, thereby preventing hospitalization. We provide a relevant review of the literature and our treatment algorithm, that can serve as a point of reference in treatment of this life-threatening complication of PRRT.

Peptide receptor radionuclide therapy as neoadjuvant therapy for resectable or potentially resectable pancreatic neuroendocrine neoplasms

Surgery ◽  
2018 ◽  
Vol 163 (4) ◽  
pp. 761-767 ◽  
Author(s):  
Stefano Partelli ◽  
Emilio Bertani ◽  
Mirco Bartolomei ◽  
Carolina Perali ◽  
Francesca Muffatti ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Radionuclide Therapy ◽  
Peptide Receptor Radionuclide Therapy ◽  
Neuroendocrine Neoplasms ◽  
Pancreatic Neuroendocrine Neoplasms ◽  
Peptide Receptor
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