Current Status of Treatment of Power Failure of the Heart in Acute Myocardial Infarction with Drugs and Blood Volume Replacement

Circulation ◽  
1969 ◽  
Vol 40 (5s4) ◽  
Author(s):  
H. J. C. SWAN ◽  
RONALD DANZIG ◽  
YOSVI SUKUMALCHANTRA ◽  
HOWARD ALLEN
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Blood Volume ◽  
Volume Replacement ◽  
Current Status ◽  
Power Failure ◽  
Blood Volume Replacement

Use of Aprotinin in the Control of Bleeding During Cardiopulmonary Bypass Surgery: Current Status

1998 ◽  
Vol 4 (1) ◽  
pp. 2-6 ◽  
Author(s):  
Roque Pifarrè
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Bypass Surgery ◽  
Whole Body ◽  
Current Status ◽  
Blood Transfusions ◽  
Donor Blood ◽  
Excessive Bleeding

Excessive bleeding is one of the major complica tions of cardiac surgery with cardiopulmonary bypass (CPB). This complication is related to the operation and the defects in hemostasis induced by extracorporeal circulation. The system atic effects of CPB are called whole body inflammatory reac tion. Heparin, platelet dysfunctions, and fibrinolysis are the major causes of bleeding problems associated with CPB. Dif ferent pharmacological approaches have been used to reduce bleeding and the need for blood transfusions in patients under going cardiac surgery. The most effective is aprotinin, a serum protease inhibitor that is an antifibrinolytic with a platelet- preserving action. It inhibits the activation of the intrinsic co agulation system. Aprotinin therapy effectively reduces blood loss and donor blood requirements. According to most reports, it does not increase the risk of acute myocardial infarction, renal dysfunction, and mortality.

Effect of associated injuries and blood volume replacement on death, rehabilitation needs, and disability in blunt traumatic brain injury

1991 ◽  
Vol 19 (10) ◽  
pp. 1252-1298 ◽  
Author(s):  
JOHN H. SIEGEL ◽  
DAVID R. GENS ◽  
TANYA MAMANTOV ◽  
FRED H. GEISLER ◽  
SHIRIN GOODARZI ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Volume ◽  
Volume Replacement ◽  
Associated Injuries ◽  
Rehabilitation Needs ◽  
Blood Volume Replacement
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