Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

Circulation ◽

10.1161/01.cir.97.12.1129 ◽

1998 ◽

Vol 97 (12) ◽

pp. 1129-1135 ◽

Cited By ~ 1174

Author(s):

Ulrich Laufs ◽

Vito La Fata ◽

Jorge Plutzky ◽

James K. Liao

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Influence of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors on endothelial nitric oxide synthase and the formation of oxidants in the vasculature

Atherosclerosis ◽

10.1016/s0021-9150(03)00100-x ◽

2003 ◽

Vol 169 (1) ◽

pp. 19-29 ◽

Author(s):

R Parker

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00214.2004 ◽

2004 ◽

Vol 287 (2) ◽

pp. H560-H566 ◽

Author(s):

M. Brennan Harris ◽

Michele A. Blackstone ◽

Sarika G. Sood ◽

Chunying Li ◽

Jonathan M. Goolsby ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.95.15.8880 ◽

1998 ◽

Vol 95 (15) ◽

pp. 8880-8885 ◽

Author(s):

M. Endres ◽

U. Laufs ◽

Z. Huang ◽

T. Nakamura ◽

P. Huang ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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HMG-CoA reductase inhibitors reduce cerebral infarct size by upregulating endothelial nitric oxide synthase

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(98)80675-x ◽

1998 ◽

Vol 31 ◽

pp. 2

Author(s):

U. Laufs ◽

M. Endres ◽

P.L. Huang ◽

M.A. Moskowitz ◽

J.K. Liao

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Infarct Size ◽

Endothelial Nitric Oxide Synthase ◽

Cerebral Infarct ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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HMG-CoA Reductase Inhibitors Reduce Cerebral Infarct Size by Upregulating Endothelial Nitric Oxide Synthase

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)83736-9 ◽

1998 ◽

Vol 31 (2) ◽

pp. 2A

Author(s):

U Laufs

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Infarct Size ◽

Endothelial Nitric Oxide Synthase ◽

Cerebral Infarct ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice

Brain Research ◽

10.1016/s0006-8993(02)02649-5 ◽

2002 ◽

Vol 942 (1-2) ◽

pp. 23-30 ◽

Author(s):

Ulrich Laufs ◽

Karen Gertz ◽

Ulrich Dirnagl ◽

Michael Böhm ◽

Georg Nickenig ◽

...

Keyword(s):

Nitric Oxide ◽

Ischemic Stroke ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Reductase Inhibitor ◽

Hmg Coa Reductase ◽

Hmg Coa Reductase Inhibitor ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Endothelial nitric oxide synthase is essential for the HMG‐CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia

The FASEB Journal ◽

10.1096/fj.01-0415fje ◽

2001 ◽

Vol 15 (13) ◽

pp. 2530-2532 ◽

Author(s):

Masataka Sata ◽

Hiroaki Nishimatsu ◽

Etsu Suzuki ◽

Seiryo Sugiura ◽

Masao Yoshizumi ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Reductase Inhibitor ◽

Hmg Coa Reductase ◽

Collateral Growth ◽

Hmg Coa Reductase Inhibitor ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase

Journal of Biological Chemistry ◽

10.1074/jbc.272.50.31725 ◽

1997 ◽

Vol 272 (50) ◽

pp. 31725-31729 ◽

Author(s):

Ulrich Laufs ◽

Vito La Fata ◽

James K. Liao

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Down Regulation ◽

Hmg Coa Reductase ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors

Atherosclerosis ◽

10.1016/s0021-9150(99)00084-2 ◽

1999 ◽

Vol 145 (2) ◽

pp. 325-331 ◽

Author(s):

José Alfon ◽

Joan F Guasch ◽

Marı́a Berrozpe ◽

Lina Badimon

Keyword(s):

Gene Expression ◽

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Intimal Thickening ◽

Hmg Coa Reductase ◽

Reductase Inhibitors ◽

Hmg Coa Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Preventive Effects

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Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.

Journal of Clinical Investigation ◽

10.1172/jci1500 ◽

1998 ◽

Vol 101 (12) ◽

pp. 2711-2719 ◽

Author(s):

O Hernández-Perera ◽

D Pérez-Sala ◽

J Navarro-Antolín ◽

R Sánchez-Pascuala ◽

G Hernández ◽

...

Keyword(s):

Nitric Oxide ◽

Endothelial Cells ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Vascular Endothelial Cells ◽

Vascular Endothelial ◽

Reductase Inhibitors ◽

Coa Reductase ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

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