scholarly journals Sex Differences in Nonculprit Coronary Plaque Microstructures on Frequency-Domain Optical Coherence Tomography in Acute Coronary Syndromes and Stable Coronary Artery Disease

2016 ◽  
Vol 9 (8) ◽  
Author(s):  
Yu Kataoka ◽  
Rishi Puri ◽  
Muhammad Hammadah ◽  
Bhanu Duggal ◽  
Kiyoko Uno ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Optical Coherence Tomography ◽  
Sex Differences ◽  
Coronary Artery ◽  
Frequency Domain ◽  
Acute Coronary Syndromes ◽  
Stable Coronary Artery Disease ◽  
Coronary Plaque ◽  
Coronary Syndromes ◽  
Artery Disease

Abstract 1521: Platelet RNA Content is Increased in Patients with Acute Coronary Syndromes Compared to Patients with stable Coronary Artery Disease and Healthy Individuals

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Erik L Grove ◽  
Anne-Mette Hvas ◽  
Steen D Kristensen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Thrombus Formation ◽  
Stable Coronary Artery Disease ◽  
Healthy Individuals ◽  
Coronary Thrombus ◽  
Coronary Syndromes ◽  
Immature Platelets ◽  
Artery Disease

Background: Platelets newly released from the bone marrow are characterized by large cell volumes and, contrary to mature platelets, contain RNA, which might reflect an increased capacity of producing proaggregatory proteins. We hypothesized that the fraction of RNA-containing, immature platelets (Immature Platelet Fraction = IPF) is a marker for acute coronary thrombus formation. Methods: Flow cytometric determination of immature platelets was conducted using a RNA fluorescent dye and an automated analyzer (Sysmex XE-2100). Measurements were performed in a total of 426 individuals (365 patients with acute coronary syndromes (ACS), 39 patients with stable coronary artery disease (CAD) and 22 healthy individuals). Results: Geometric mean IPF was 2.5 (CV = 0.37) in the control group, 2.9 (0.43) in patients with stable CAD, 3.0 (0.55) in the non-STEMI/Unstable Angina group and 3.7 (0.56) in patients with STEMI. IPF was significantly increased in STEMI patients compared to all other groups (t-test for log-transformed data: p < 0.004), and the overall difference between groups was significant (ANOVA: p < 0.0001). IPF was increased in active smokers among patients with ACS (3.2 vs 3.6, p=0.02), whereas no relation with age, sex, body mass index or CRP levels was observed. Conclusion: The fraction of RNA-containing platelets is increased in ACS, especially in the acute phase of STEMI. Immature platelets with an increased haemostatic potential may contribute to coronary thrombus formation and may partly explain previous findings of temporary resistance to anti-platelet therapy.

scholarly journals Oxidized LDL and Malondialdehyde-Modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease

Circulation ◽  
1998 ◽  
Vol 98 (15) ◽  
pp. 1487-1494 ◽  
Author(s):  
Paul Holvoet ◽  
Johan Vanhaecke ◽  
Stefaan Janssens ◽  
Frans Van de Werf ◽  
Désiré Collen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Oxidized Ldl ◽  
Stable Coronary Artery Disease ◽  
Modified Ldl ◽  
Coronary Syndromes ◽  
Artery Disease

scholarly journals Sex Differences in Modifiable Risk Factors and Severity of Coronary Artery Disease

2020 ◽  
Vol 9 (19) ◽  
Author(s):  
Olivia Manfrini ◽  
Jinsung Yoon ◽  
Mihaela van der Schaar ◽  
Sasko Kedev ◽  
Marija Vavlukis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Sex Differences ◽  
Coronary Artery ◽  
Acute Coronary Syndromes ◽  
Link Type ◽  
Coronary Syndromes ◽  
Traditional Risk Factors ◽  
Artery Disease

Background It is still unknown whether traditional risk factors may have a sex‐specific impact on coronary artery disease (CAD) burden. Methods and Results We identified 14 793 patients who underwent coronary angiography for acute coronary syndromes in the ISACS‐TC (International Survey of Acute Coronary Syndromes in Transitional Countries; Clini​calTr​ials.gov , NCT01218776) registry from 2010 to 2019. The main outcome measure was the association between traditional risk factors and severity of CAD and its relationship with 30‐day mortality. Relative risk (RR) ratios and 95% CIs were calculated from the ratio of the absolute risks of women versus men using inverse probability of weighting. Estimates were compared by test of interaction on the log scale. Severity of CAD was categorized as obstructive (≥50% stenosis) versus nonobstructive CAD. The RR ratio for obstructive CAD in women versus men among people without diabetes mellitus was 0.49 (95% CI, 0.41–0.60) and among those with diabetes mellitus was 0.89 (95% CI, 0.62–1.29), with an interaction by diabetes mellitus status of P =0.002. Exposure to smoking shifted the RR ratios from 0.50 (95% CI, 0.41–0.61) in nonsmokers to 0.75 (95% CI, 0.54–1.03) in current smokers, with an interaction by smoking status of P =0.018. There were no significant sex‐related interactions with hypercholesterolemia and hypertension. Women with obstructive CAD had higher 30‐day mortality rates than men (RR, 1.75; 95% CI, 1.48–2.07). No sex differences in mortality were observed in patients with nonobstructive CAD. Conclusions Obstructive CAD in women signifies a higher risk for mortality compared with men. Current smoking and diabetes mellitus disproportionally increase the risk of obstructive CAD in women. Achieving the goal of improving cardiovascular health in women still requires intensive efforts toward further implementation of lifestyle and treatment interventions. Registration URL: https://www.clini​caltr​ials.gov ; Unique identifier: NCT01218776.

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