COVID-19 (Coronavirus disease) is the most contagious virus, which has been characterized
as a global pandemic by WHO. The pathological cycle of COVID-19 virus can be specified as
RNAaemia, severe pneumonia, along with the Ground-glass opacity (GGO), and acute cardiac injury.
The S protein of Coronavirus has been reported to be involved in the entry of the virus into
the host cell, which can be accomplished by direct membrane fusion between the virus and plasma
membrane. In the endoplasmic reticulum or Golgi membrane, the newly formed enveloped glycoproteins
are introduced. The spread of disease occurs due to contact and droplets unleashed by the
vesicles holding the virus particles combined with the plasma membrane to the virus released by
the host. The present manuscript describes the pathogenesis of COVID-19 and various treatment
strategies that include drugs such as chloroquine and hydroxychloroquine, an anti-malarial drug,
antibodies: SARS-CoV-specific human monoclonal antibody CR3022 and plasma treatment facilitate
the therapeutic effect.
Letter by Wong and Siu Regarding Article, “Microthrombi as a Major Cause of Cardiac Injury in COVID-19: A Pathologic Study”
