Plasma Haemoglobin A1c (HbA1c) Concentration And Cardiovascular Complications In Obstructive Sleep Apnoea (OSA) Patients With And Without Diabetes

2010 ◽  
Author(s):  
Robert Plywaczewski ◽  
Barbara Kazanecka ◽  
Dorota Gorecka ◽  
Pawel Sliwinski
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Cardiovascular Complications ◽  
Sleep Apnoea ◽  
Haemoglobin A1c ◽  
Plasma Haemoglobin ◽  
Obstructive Sleep ◽  
Hba1c Concentration

scholarly journals Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review

2021 ◽  
Vol 30 (160) ◽  
pp. 200220
Author(s):  
Xiaoman Zhang ◽  
Shengming Wang ◽  
Huajun Xu ◽  
Hongliang Yi ◽  
Jian Guan ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Intermittent Hypoxia ◽  
Sleep Disordered Breathing ◽  
Acid Metabolism ◽  
Cardiovascular Complications ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Integral Role ◽  
Microbiome Profiling ◽  
Shed Light

IntroductionObstructive sleep apnoea (OSA) is a common sleep disorder with a high social and economic burden. Thus, early prediction and diagnosis of OSA are important. Changes in metabolism and the microbiome may serve as biomarkers for OSA. Herein, we review the literature on the metabolomic and microbiome changes associated with OSA, and identify the metabolites and microorganisms involved.MethodsWe searched the PUBMED and EMBASE electronic databases using the following terms: “obstructive sleep apnea”, “OSA”, “sleep disordered breathing”, “SDB”, “intermittent hypoxia”, “sleep fragmentation”, and either “metabolomics” or “microbiome”. In total, 273 papers were identified, of which 28 were included in our study.ResultsChanges in the levels of certain metabolites related to fatty acid, carbohydrate and amino acid metabolism were associated with the incidence of OSA. The diversity and abundance of microflora, particularly Firmicutes and Bacteroidetes, were altered in humans and rodents with OSA.ConclusionsCertain changes in metabolism and the microbiota play an integral role in the pathophysiology of OSA and OSA-induced cardiovascular complications. Metabolomic and microbiome biomarkers shed light on the pathogenesis of OSA, and facilitate early diagnosis and treatment.

scholarly journals Predictors of perioperative complications following single or combination nasal-palatopharyngeal surgery for severe obstructive sleep apnoea

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Zamzil Amin Asha'ari ◽  
Jamalludin Ab Rahman ◽  
Wan Ishlah Wan Leman
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Perioperative Complications ◽  
Upper Airway ◽  
Cardiovascular Complications ◽  
Sleep Apnoea ◽  
Complication Rates ◽  
Tertiary Referral Hospital ◽  
Upper Airway Surgery ◽  
Airway Surgery ◽  
Obstructive Sleep

Introduction: To assess the relationship between perioperative complications and upper airway surgeries for obstructive sleep apnoea (OSA). Methods: The records of 118 adult patients, diagnosed with obstructive sleep apnoea (apnoea-hypopnoea index (AHI) >5), who underwent upper airway surgery at a single tertiary referral hospital from 2007 to 2015 were reviewed. Pulmonary, surgical, and cardiovascular complications within the first 30 postoperative days were analyzed according to types of upper airway surgery. Upper airway surgery types were single surgery or combinations of surgeries to the tonsils, pharyngeal adenoids, soft palate, tongue base and nose. Logistic regression was used to assess the multivariable association of age, sex, BMI, OSA severity, medical comorbidity, and types of upper airway surgery with postoperative complications. Results: At least one perioperative complications occurred in 48 of 128 patients (37.5%). In a multivariable model, the overall complication rate was increased with age, obesity, smoking and underlying comorbid medical problems. Complication rates were not associated with AHI severity, types of procedures performed and whether the surgery was a single or combination surgery. Conclusions: In OSA patients undergoing upper airway surgery, the severity of OSA as assessed by the AHI, and the sites and numbers of concurrent surgery performed were not associated with the rate of perioperative complications.

The severity of obstructive sleep apnoea does not influence ambient IGF-I levels

2017 ◽  
Author(s):  
Julie Lynch ◽  
Nikolaos Kyriakakis ◽  
Mark Elliott ◽  
Dipansu Ghosh ◽  
Mitchell Nix ◽  
...  
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep ◽  
Igf I
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