Carbon Monoxide-induced Autophagy Inhibits The Mortality Of Cecal Ligation And Puncture-induced Sepsis Model

2010 ◽  
Author(s):  
Seon-Jin Lee ◽  
Suwol Chung ◽  
Hong Pyo Kim ◽  
Mark A. Perrella ◽  
Augustine M.K. Choi
Keyword(s):  
Carbon Monoxide ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture ◽  
Sepsis Model

Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats

Shock ◽  
2009 ◽  
pp. 1 ◽  
Author(s):  
Elif Cadirci ◽  
Berrin Zuhal Altunkaynak ◽  
Zekai Halici ◽  
Fehmi Odabasoglu ◽  
M. Hamidullah Uyanik ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lipoic Acid ◽  
Cecal Ligation ◽  
Alpha Lipoic Acid ◽  
Cecal Ligation And Puncture ◽  
Potential Target ◽  
Sepsis Model

scholarly journals Volatile Anesthetics Improve Survival after Cecal Ligation and Puncture

2013 ◽  
Vol 119 (4) ◽  
pp. 901-906 ◽  
Author(s):  
Inge K. Herrmann ◽  
Maricela Castellon ◽  
David E. Schwartz ◽  
Melanie Hasler ◽  
Martin Urner ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cecal Ligation ◽  
Volatile Anesthetics ◽  
Study Data ◽  
Cecal Ligation And Puncture ◽  
Immunomodulatory Effects ◽  
Organ Function ◽  
Minimal Alveolar Concentration ◽  
Sepsis Model ◽  
Sepsis Induction

Abstract Background: Sepsis remains a leading cause of death in intensive care units. There is growing evidence that volatile anesthetics have beneficial immunomodulatory effects on complex inflammation-mediated conditions. The authors investigated the effect of volatile anesthetics on the overall survival of mice in a sepsis model of cecal ligation and puncture (CLP). Methods: Mice (N = 12 per treatment group) were exposed to anesthetic concentrations of desflurane, isoflurane, and sevoflurane either during induction of sepsis or when the mice showed pronounced symptoms of inflammation. Overall survival, as well as organ function and inflammation was compared with the CLP group without intervention. Results: With desflurane and sevoflurane conditioning (1.2 minimal alveolar concentration for 2 h immediately after induction of CLP) overall survival was improved to 58% and 83%, respectively, compared with 17% in the untreated CLP group. Isoflurane did not significantly affect outcome. Application of sevoflurane 24 h after sepsis induction significantly improved overall survival to 66%. Conclusions: Administration of the volatile anesthetics desflurane and sevoflurane reduced CLP-induced mortality. Anesthesia may be a critical confounder when comparing study data where different anesthesia protocols were used.

Comparative Study on Effects of Nebulized and Oral Salbutamol on a Cecal Ligation and Puncture-Induced Sepsis Model in Rats

Drug Research ◽  
2014 ◽  
Vol 65 (04) ◽  
pp. 192-198
Author(s):  
B. Ozogul ◽  
Z. Halici ◽  
E. Cadirci ◽  
E. Karagoz ◽  
Z. Bayraktutan ◽  
...  
Keyword(s):  
Comparative Study ◽  
Cecal Ligation ◽  
Cecal Ligation And Puncture ◽  
Sepsis Model

Abstract 330: LDK378 Attenuates Macro and Microcirculation in a Sepsis Rat Model Induced by Cecal Ligation and Puncture

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_2) ◽  
Author(s):  
Weiwei Ge ◽  
Zhengfei Yang ◽  
Qiaohua Hu ◽  
Xuefen Liu ◽  
Qin Ling ◽  
...  
Keyword(s):  
Rat Model ◽  
Inflammatory Mediator ◽  
Myocardial Dysfunction ◽  
Cecal Ligation ◽  
Male Rats ◽  
Flow Index ◽  
Cecal Ligation And Puncture ◽  
Sublingual Microcirculation ◽  
Sepsis Model ◽  
Severe Infections

Background: Sepsis is a systemic inflammatory response syndrome caused by severe infections. Myocardial dysfunction has been associated with increased mortality in septic patients. Previous studies have demonstrated that LDK378, a second-generation ALK inhibitor, is a potential anti-inflammatory mediator. We investigated the effects of LDK378 on macro and microcirculation in a rat model of cecal ligation and puncture (CLP) induced sepsis. Hypothesis: LDK378 attenuates the deleterious effects of sepsis on macro- and micro- circulation in CLP induced septic rats. Method: Fifteen male rats weighing between 450-550g were randomized into three groups: Sham, CLP, and CLP+LDK378. Our rat sepsis model was induced by 50% cecum ligation and two punctures with a 20-gauge needle. LDK378 (20mg/kg) was administered intraperitoneal (IP) to animals at 0h, 24h and 48 hours after CLP operation in the CLP+LDK378 group. Cardiac output (CO), mean arterial pressure (MAP); sublingual microcirculation including perfused small vessel density (PVD) and microcirculatory flow index (MFI) were measured at 6h, 30h and 54h after CLP. Results: Significant reduction in CO, MAP, MFI and PVD were observed in both CLP and CLP+LDK378 groups at 6h, 30h and 54h. However, the levels of CO, MAP, MFI and PVD reduction were significantly better in the CLP+LDK378 group when compared with the CLP group at 30h and 54h after CLP. Conclusion: LDK378 attenuates macro and microcirculation parameters in our rat model of sepsis.

Sign in / Sign up

Export Citation Format

Share Document