Impaired Dendritic Cell Migration Contributes To Allergen-Induced Epithelial Accumulation And Decreased Lymph-Node Homing Of Myeloid Dendritic Cells In The Chronic Granulomatous Disease (CGD) Lung In Mice

2012 ◽  
Author(s):  
Lisa R. Forbes ◽  
Pedro J. Cejas ◽  
Blerina Ducka ◽  
Imre Redai ◽  
Angela Haczku
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Lymph Node ◽  
Dendritic Cell ◽  
Chronic Granulomatous Disease ◽  
Granulomatous Disease ◽  
Myeloid Dendritic Cells ◽  
Lymph Node Homing ◽  
Dendritic Cell Migration

scholarly journals PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

Cell Reports ◽  
2020 ◽  
Vol 33 (2) ◽  
pp. 108258
Author(s):  
Erin D. Lucas ◽  
Johnathon B. Schafer ◽  
Jennifer Matsuda ◽  
Madison Kraus ◽  
Matthew A. Burchill ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Reverse Signaling ◽  
Skin Immunity ◽  
Dendritic Cell Migration

scholarly journals Leishmania amazonensis infection impairs dendritic cell migration from the inflammatory site to the draining lymph node

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Micely DR Hermida ◽  
Priscila G Doria ◽  
Angela MP Taguchi ◽  
José O Mengel ◽  
Washington LC dos-Santos
Keyword(s):  
Cell Migration ◽  
Lymph Node ◽  
Dendritic Cell ◽  
Leishmania Amazonensis ◽  
Inflammatory Site ◽  
Dendritic Cell Migration ◽  
Draining Lymph Node

scholarly journals Regulation of Intestinal Dendritic Cell Migration and Activation by Plasmacytoid Dendritic Cells, TNF-α and Type 1 IFNs after Feeding a TLR7/8 Ligand

2006 ◽  
Vol 176 (9) ◽  
pp. 5205-5212 ◽  
Author(s):  
Ulf Yrlid ◽  
Simon W. F. Milling ◽  
Joanna L. Miller ◽  
Sian Cartland ◽  
Christopher D. Jenkins ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cells ◽  
Tnf Α ◽  
Dendritic Cell Migration

MYCOPHENOLIC ACID IMPEDES ANTIGEN PRESENTING AND LYMPH NODE HOMING CAPACITIES OF HUMAN BLOOD MYELOID DENDRITIC CELLS

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 727-728
Author(s):  
V R. Cicinnati ◽  
J Hou ◽  
M Lindemann ◽  
A Radtke ◽  
C G. Klein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Node ◽  
Human Blood ◽  
Mycophenolic Acid ◽  
Myeloid Dendritic Cells ◽  
Lymph Node Homing ◽  
Antigen Presenting

scholarly journals Vimentin provides target search efficiency and mechanical resilience for dendritic cell migration

2020 ◽  
Author(s):  
Luiza Da Cunha Stankevicins ◽  
M. Reza Shaebani ◽  
Doriane Vesperini ◽  
Marta Urbanska ◽  
Daniel A. D. Flormann ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Cell Stiffness ◽  
Search Efficiency ◽  
Mechanical Stiffness ◽  
Target Search ◽  
Dendritic Cell Migration

AbstractDendritic cells use amoeboid migration to pass through confined tissues to reach the lymph nodes, and this homing function is crucial for immune responses. The underlying mechanisms for this type of migration remain unknown. As vimentin intermediate filaments regulate adhesion-dependent migration, we analyzed whether they have a similar effect on amoeboid migration. We show that lack of vimentin impairs amoeboid migration in vitro in confined environments, and blocks lymph-node homing in mice in vivo. Importantly, we show that vimentin-deficient dendritic cells have a lower coupling factor between cell speed and persistence and reduced target search efficiency (e.g., finding a pathogen, or another cell). These data show that the characteristics of vimentin in its dynamic regulation of cell stiffness and load-bearing, and also elastic capacity, appear to explain the coupling between their migratory ability and search efficiency. Taken together, these data show that vimentin provides the specific mechano-dynamics required for dendritic cell migration and for efficient target searching.Summary statementVimentin contributes to the mechanical stiffness of cells required for amoeboid cell migration through confined spaces, and improves cell-search efficiency. Vimentin-deficient cells migrate more slowly and their migration speed is less coupled to persistence compared to control cells.

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