New Insights into the Regulation of Endothelial Lung Permeability in Pneumonia. The Interplay between Angiopoietins 1 and 2

2018 ◽  
Vol 198 (2) ◽  
pp. 149-150 ◽  
Author(s):  
Antoni Torres
Keyword(s):  
1983 ◽  
Vol 14 (3) ◽  
pp. 205-207
Author(s):  
Gunter Oberdörster ◽  
Mark J. Utell ◽  
David A. Weber ◽  
Mariana Ivanovich ◽  
Richard W. Hyde ◽  
...  

1989 ◽  
Vol 83 (4) ◽  
pp. 323-327 ◽  
Author(s):  
M.C. Sweatman ◽  
C.F.A. Pantin ◽  
R. Lawrence ◽  
M. Turner-Warwick

1986 ◽  
Vol 41 (6) ◽  
pp. 620-626 ◽  
Author(s):  
R. Winn ◽  
J. Gleisner ◽  
R. Maunder ◽  
J. Harlan ◽  
J. Hildebrant
Keyword(s):  

Respiration ◽  
2001 ◽  
Vol 68 (3) ◽  
pp. 313-317 ◽  
Author(s):  
Patrice Diot ◽  
Elisabeth Galinier ◽  
Daniel Grimbert ◽  
Sylvie Bugeon ◽  
Chantal Valat ◽  
...  

1990 ◽  
Vol 16 (6) ◽  
pp. 593-605 ◽  
Author(s):  
Maurizio M. Anceschi ◽  
Bengt Robertson ◽  
Lorena Broccucci ◽  
Antonella Barbati ◽  
Gertie Grossmann ◽  
...  
Keyword(s):  

2007 ◽  
Vol 70 (3-4) ◽  
pp. 284-294 ◽  
Author(s):  
C. Y. de Burbure ◽  
J.-F. Heilier ◽  
J. Nève ◽  
A. Becker ◽  
C. Albrecht ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yi Yang ◽  
Shuling Hu ◽  
Xiuping Xu ◽  
Jinze Li ◽  
Airan Liu ◽  
...  

Recently, mesenchymal stem cells (MSC) have been proved to be beneficial in acute respiratory distress syndrome (ARDS). Vascular endothelial growth factor (VEGF) is an important angiogenesis factor that MSC release. However, the precise role of VEGF-expressing character of MSC in the MSC treatment for ARDS remains obscure. Here, we firstly knocked down the gene VEGF in MSC (MSC-ShVEGF) with lentiviral transduction. Then we injected the MSC-ShVEGF to rats with lipopolysaccharide-induced acute lung injury (ALI) via the tail vein. Data showed that MSC transplantation significantly increased VEGF levels in the lung, reduced lung permeability, protected lung endothelium from apoptosis, facilitated VE-cadherin recovery, controlled inflammation, and attenuated lung injury. However, VEGF gene knockdown in MSC led to relatively insufficient VEGF expression in the injured lung and significantly diminished the therapeutic effects of MSC on ALI, suggesting an important role of VEGF-expressing behavior of MSC in the maintenance of VEGF in the lung and the MSC treatment for ALI. Hence, we conclude that MSC restores the lung permeability and attenuates lung injury in rats with ALI in part by maintaining a “sufficient” VEGF level in the lung and the VEGF-expressing character of MSC plays a positive role in the therapeutic effects of MSC on ARDS.


Respiration ◽  
1989 ◽  
Vol 55 (1) ◽  
pp. 79-83 ◽  
Author(s):  
A. Mistretta ◽  
N. Crimi ◽  
F. Palermo ◽  
R. Oliveri ◽  
C. Vancheri ◽  
...  
Keyword(s):  

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