Effects of Lomerizine, a Calcium Channel Antagonist, on Retinal and Optic Nerve Head Circulation in Rabbits and Humans

2003 ◽  
Vol 44 (11) ◽  
pp. 4864 ◽  
Author(s):  
Yasuhiro Tamaki ◽  
Makoto Araie ◽  
Yasuhiro Fukaya ◽  
Miyuki Nagahara ◽  
Asuka Imamura ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Calcium Channel ◽  
Optic Nerve Head ◽  
Calcium Channel Antagonist ◽  
Optic Nerve Head Circulation

Optic Nerve Head Circulation After Topical Calcium Channel Blocker

1996 ◽  
Vol 5 (3) ◽  
pp. 200???206 ◽  
Author(s):  
Peter A. Netland ◽  
Gilbert T. Feke ◽  
Suguru Konno ◽  
Douglas G. Goger ◽  
Naoki Fujio
Keyword(s):  
Optic Nerve ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Optic Nerve Head ◽  
Channel Blocker ◽  
Optic Nerve Head Circulation

Influence of Nifedipine on the Visual Fields of Patients with Optic-Nerve-Head Diseases

1994 ◽  
Vol 4 (1) ◽  
pp. 24-28 ◽  
Author(s):  
A.Z. Gaspar ◽  
J. Flammer ◽  
PH. Hendrickson
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Optic Nerve Head ◽  
Channel Blocker ◽  
Glaucoma Patient ◽  
Visual Fields ◽  
Visual Field Defects ◽  
Channel Blockers

Calcium-channel blockers have long been employed in coronary disease, and recent investigations have indicated their efficacy in improving the visual field in low-tension glaucoma or presumed vasospasm, possibly by enhancing ocular circulation. We evaluated the short-term influence of a typical calcium-channel blocker, nifedipine, on 59 patients with visual-field defects, some with optic-nerve-head pathology (n = 38) and some with normal-appearing optic nerve heads (n = 21). On the average, a statistically significant improvement of 1.2 dB was observed. Different types of patients, however, behaved quite differently. The younger the patient, the greater the improvement. Patients with normal optic nerve heads improved by 1.54 dB, whereas patients with optic-nerve-head excavation improved by only 0.66 dB. No response was observed in patients with anterior ischemic neuropathy. Marked deterioration was noted in one glaucoma patient with low systemic blood pressure. The visual-field changes were observed in the scotomatous and non-scotomatous areas. Thus, the calcium-channel blocker nifedipine can be effective in some selected diseases whose pathogenesis probably involves vascular dysregulation though it may even be contraindicated in others

Effects of Semotiadil, A Novel Calcium Antagonist, on the Retina and Optic Nerve Head Circulation

2000 ◽  
Vol 16 (3) ◽  
pp. 231-239 ◽  
Author(s):  
KEN TOMITA ◽  
ATSUO TOMIDOKORO ◽  
YASUHIRO TAMAKI ◽  
MAKOTO ARAIE ◽  
MASAO MATSUBARA ◽  
...  
Keyword(s):  
Calcium Antagonist ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optic Nerve Head Circulation
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