Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma

2010 ◽  
Vol 51 (6) ◽  
pp. 2968 ◽  
Author(s):  
Edward W. Dervan ◽  
Hong Chen ◽  
Su Ling Ho ◽  
Nikola Brummel ◽  
Jasmin Schmid ◽  
...  
Keyword(s):  
Pseudoexfoliation Glaucoma ◽  
Protein Macroarray

Phaco-canaloplasty in patients with pseudoexfoliation glaucoma – Six-year results

2018 ◽  
pp. 84-87
Author(s):  
J.V. Hasanov ◽  
◽  
K.I. Ramazanova ◽  
N.A. Hasanova ◽  
◽  
...  
Keyword(s):  
Pseudoexfoliation Glaucoma

Comparison of phaco time parameters in eyes with and without glaucoma filtration surgery due to pseudoexfoliation glaucoma

2021 ◽  
pp. 112067212110177
Author(s):  
Ayse Gul Kocak Altintas ◽  
Cagri Ilhan
Keyword(s):  
Clinical Characteristics ◽  
Pseudoexfoliation Glaucoma ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Mean Values ◽  
Time Parameters ◽  
The Mean ◽  
Group 2 ◽  
Surgical Manipulations ◽  
Phaco Time

Purpose: To compare the phaco time parameters including ultrasound time (UST), effective phaco time (EPT), and average phaco power (APP) in eyes with pseudoexfoliation glaucoma (PEG) and had or had not glaucoma filtration surgery. Methods: In this retrospective comparative study, Group 1 was constructed with 84 PEG patients who had not operated previously, and Group 2 was constructed with 49 PEG patients who had glaucoma filtration surgery. The mean values of UST, EPT, and APP were compared. The preoperative clinical characteristics and surgical manipulations were also compared. Results: The mean ages and male-to-female ratios of the groups were similar ( p > 0.05, for both). There was no difference in the preoperative clinical characteristics, including biometric values between the groups ( p > 0.05, for all). Some surgical manipulations, including pupillary stretching ( p = 0.004), pupillary membrane peeling ( p = 0.021), iris hook using ( p = 0.041), and capsular tension ring implantation ( p = 0.041), were significantly performed more commonly in Group 2. Although the mean UST and EPT values were similar ( p > 0.05, for both), the mean APP value was significantly lower in Group 2 ( p = 0.011). Conclusion: The lower APP parameter was observed in PEG patients having had glaucoma filtration surgery. Needing more surgical manipulation to overcome poor pupillary dilation and weak zonular instability can be a reason for this result.

Pseudoexfoliation syndrome and pseudoexfoliation glaucoma in New Zealand Māori

2017 ◽  
Vol 46 (4) ◽  
pp. 437-438 ◽  
Author(s):  
Samuel J Newlands ◽  
Graham A Wilson
Keyword(s):  
New Zealand ◽  
Pseudoexfoliation Syndrome ◽  
Pseudoexfoliation Glaucoma

scholarly journals Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Vanessa M. Beutgen ◽  
Norbert Pfeiffer ◽  
Franz H. Grus
Keyword(s):  
Open Angle Glaucoma ◽  
Protein Microarray ◽  
Enrichment Analysis ◽  
Normal Tension Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Serum Samples ◽  
Protein Protein Interaction ◽  
Circulating Autoantibodies

Evidence for immunologic contribution to glaucoma pathophysiology is steadily increasing in ophthalmic research. Particularly, an altered abundance of circulating autoantibodies to ocular antigens is frequently observed. Here, we report an analysis of autoantibody abundancies to selected antigens in sera of open-angle glaucoma patients, subdivided into normal-tension glaucoma (N = 31), primary open-angle glaucoma (N = 43) and pseudoexfoliation glaucoma (N = 45), vs. a non-glaucomatous control group (N = 46). Serum samples were analyzed by protein microarray, including 38 antigens. Differences in antibody levels were assessed by ANOVA. Five serological antibodies showed significantly altered levels among the four groups (P < 0.05), which can be used to cluster the subjects in groups consisting mainly of PEXG or POAG/NTG samples. Among the altered autoantibodies, anti-Clathrin antibodies were identified as most important subgroup predictors, enhancing prospective glaucoma subtype prediction. As a second aim, we wanted to gain further insights into the characteristics of previously identified glaucoma-related antigens and their role in glaucoma pathogenesis. To this end, we used the bioinformatics toolset of Metascape to construct protein-protein interaction networks and GO enrichment analysis. Glaucoma-related antigens were significantly enriched in 13 biological processes, including mRNA metabolism, protein folding, blood coagulation and apoptosis, proposing a link of glaucoma-associated pathways to changes in the autoantibody repertoire. In conclusion, our study provides new aspects of the involvement of natural autoimmunity in glaucoma pathomechanisms and promotes advanced opportunities toward new diagnostic approaches.

Elevated Expression of Dickkopf-1 and Vimentin Promotes Aggresome Deposition and Serve as Biomarkers for Pseudoexfoliation Glaucoma

2021 ◽  
Author(s):  
Ramani Shyam Kapuganti ◽  
Bushra Hayat ◽  
Biswajit Padhy ◽  
Pranjya Paramita Mohanty ◽  
Debasmita Pankaj Alone
Keyword(s):  
Pseudoexfoliation Glaucoma ◽  
Elevated Expression ◽  
Dickkopf 1

The haplotype of the CDKN2B-AS1 gene is associated with primary open-angle glaucoma and pseudoexfoliation glaucoma in the Caucasian population of Central Russia

2021 ◽  
pp. 1-8
Author(s):  
Natalya Eliseeva ◽  
Irina Ponomarenko ◽  
Evgeny Reshetnikov ◽  
Volodymyr Dvornyk ◽  
Mikhail Churnosov
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Caucasian Population ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Central Russia

Glaucomas: Pseudoexfoliation Glaucoma

2016 ◽  
pp. 411-418
Author(s):  
Richard K. Lee
Keyword(s):  
Pseudoexfoliation Glaucoma

Comparative Results of Central Corneal Thickness Measurements in Primary Open-Angle Glaucoma, Pseudoexfoliation Glaucoma, and Ocular Hypertension

2008 ◽  
Vol 39 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Spiridon Gorezis ◽  
Gartzos Christos ◽  
Maria Stefaniotou ◽  
Kostantinos Moustaklis ◽  
Aggelos Skyrlas; Georgios Kitsos
Keyword(s):  
Ocular Hypertension ◽  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Comparative Results ◽  
Thickness Measurements
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