Twenty-Four–Hour Pattern of Intraocular Pressure in Untreated Patients with Ocular Hypertension

Objective: To evaluate changes in intraocular pressure after congenital cataract surgery in a real-world setting. Methods: This retrospective case series included all children aged 0–2 years undergoing lens extraction due to congenital cataract. Development of an elevated intraocular pressure was divided into three groups: secG, suspG and OHT. Further, risk factors for IOP changes, the therapeutic approach and functional outcome were assessed during follow-up. Results: One hundred and sixty-one eyes of 110 patients aged 0–2 years were included, whereof 29 eyes of 17 children developed secondary glaucoma (secG; 11 eyes/8 patients), glaucoma suspect (suspG; three eyes/three patients) or ocular hypertension (OHT; 15 eyes/10 patients). No difference in surgrical procedure ( p = 0.62) was found, but age at cataract surgery differed significantly ( p = 0.048), with the secG group (1.74 ± 1.01 months) being the youngest (suspG: 3.93 ± 1.80 months; OHT group: 5.91 ± 5.36 months). Secondary surgical intervention was significantly higher in the secG (4.64 ± 3.41) followed by the suspG (2.00 ± 2.65) and OHT groups (0.40 ± 0.74; p < 0.001). Postoperative complications including nystagmus ( p = 0.81), strabismus ( p = 0.98) and amblyopia ( p = 0.73) showed no difference, in contrast to visual axis obscuration which was more common in the secG group ( p = 0.036). Conclusion: Initial lensectomy and anterior vitrectomy procedure together with or without IOL implantation seems to have no influence for the development of IOP changes after pediatric cataract surgery. However, children who developed secondary glaucoma had cataract surgery significantly earlier, within the first 2–3 months of life. Glaucoma surgery was required to achieve final IOP control in most eyes. The development of secondary glaucoma was also associated with a significant increase in surgical re-treatments.

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Stanniocalcin-1 Reduced Intraocular Pressure in Two Models of Ocular Hypertension

Current Eye Research ◽

10.1080/02713683.2021.1899246 ◽

2021 ◽

pp. 1-6

Author(s):

Gavin W. Roddy ◽

Uttio Roy Chowdhury ◽

Kjersten J. Monson ◽

Michael P. Fautsch

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension

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Minimum Concentration of Levobunolol Required To Control Intraocular Pressure in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension

American Journal of Ophthalmology ◽

10.1016/s0002-9394(14)75860-x ◽

1985 ◽

Vol 99 (1) ◽

pp. 18-22 ◽

Cited By ~ 13

Author(s):

Daniel Long ◽

Thom Zimmerman ◽

George Spaeth ◽

Gary Novack ◽

P. Joshua Burke ◽

...

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Minimum Concentration

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A Comparison of the Intervisit Intraocular Pressure Fluctuation After 180 and 360 Degrees of Selective Laser Trabeculoplasty (SLT) as a Primary Therapy in Primary Open Angle Glaucoma and Ocular Hypertension

Journal of Glaucoma ◽

10.1097/ijg.0b013e3181752c97 ◽

2009 ◽

Vol 18 (2) ◽

pp. 157-160 ◽

Cited By ~ 33

Author(s):

Navin Prasad ◽

Shashidhar Murthy ◽

John J. Dagianis ◽

Mark A. Latina

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension ◽

Pressure Fluctuation ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Primary Therapy ◽

Open Angle ◽

Selective Laser Trabeculoplasty ◽

Laser Trabeculoplasty ◽

Intraocular Pressure Fluctuation

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The RELIEF study: Tolerability and efficacy of preservative-free latanoprost in the treatment of glaucoma or ocular hypertension

European Journal of Ophthalmology ◽

10.1177/1120672118785280 ◽

2018 ◽

Vol 29 (2) ◽

pp. 210-215 ◽

Cited By ~ 6

Author(s):

Marta Misiuk-Hojlo ◽

Maria Pomorska ◽

Malgorzata Mulak ◽

Marek Rekas ◽

Joanna Wierzbowska ◽

...

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Standard Deviation ◽

Ocular Hypertension ◽

Benzalkonium Chloride ◽

Tear Film ◽

Corrected Visual Acuity ◽

Break Up ◽

Preservative Free ◽

Best Corrected Visual Acuity

Purpose: To assess tolerability and efficacy following a switch from benzalkonium chloride–latanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension. Methods: A total of 140 patients with glaucoma or ocular hypertension controlled with benzalkonium chloride-latanoprost for at least 3 months were switched to treatment with preservative-free latanoprost. Assessments were made on days 15, 45, and 90 (D15, D45, and D90) and included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, and subjective estimation of tolerability. Results: Mean best-corrected visual acuity remained unchanged during the study. Mean intraocular pressure compared with baseline (D0) remained stable throughout the study (D0, 15.9 mmHg (standard deviation = 2.6); D90, 15.3 mmHg (standard deviation = 2.4); p < 0.006). Tear film break-up time improved or remained unchanged relative to baseline in 92% of patients at D45 and in 93% at D90. Moderate-to-severe conjunctival hyperemia was seen in 56.8% of patients at D0, but this figure decreased to 13.7%, 2.2%, and 1.6% at D15, D45, and D90, respectively. Subjective assessment of tolerability (0–10 scale) indicated improvement with change of therapy (mean score: 5.3 (standard deviation = 2.2) at D0 versus 1.9 (standard deviation = 1.7) at D90; p < 0.0001). Conclusion: Preservative-free latanoprost has at least the same intraocular pressure-lowering efficacy as benzalkonium chloride–latanoprost, with a better tolerability profile. This may translate into greater control of treatment and improved quality of life.

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The Effect of D-Timolol On Intraocular Pressure In Patients With Ocular Hypertension

American Journal of Ophthalmology ◽

10.1016/0002-9394(84)90191-0 ◽

1984 ◽

Vol 98 (1) ◽

pp. 73-78 ◽

Cited By ~ 28

Author(s):

Edwin U. Keates ◽

Richard Stone

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension

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Comparison of intraocular pressure-lowering effects of ripasudil hydrochloride hydrate for inflammatory and corticosteroid-induced ocular hypertension

PLoS ONE ◽

10.1371/journal.pone.0185305 ◽

2017 ◽

Vol 12 (10) ◽

pp. e0185305 ◽

Cited By ~ 7

Author(s):

Mami Yasuda ◽

Kei Takayama ◽

Takayuki Kanda ◽

Manzo Taguchi ◽

Hideaki Someya ◽

...

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension ◽

Pressure Lowering

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Preservative-free versus preserved latanoprost eye drops for reducing intraocular pressure: a non-inferiority phase III randomized, multi-center, single-blind, parallel-group controlled trial

Medical hypothesis discovery and innovation in ophthalmology ◽

10.51329/mehdiophthal1413 ◽

2021 ◽

Vol 9 (4) ◽

Author(s):

Panos Theodosiadis ◽

Anastasios Konstas ◽

Ioannis Halkiadakis ◽

Vasiliki Dimera ◽

Dimitrios Koufakis ◽

...

Keyword(s):

Intraocular Pressure ◽

Ocular Hypertension ◽

Open Angle Glaucoma ◽

Ophthalmic Solution ◽

Phase Iii ◽

Point Estimate ◽

Eye Drops ◽

Open Angle ◽

Parallel Group ◽

Preservative Free

Background: The aim of this study was to test the non-inferiority of preservative-free (PF) latanoprost 50 μg/mL multi-dose ophthalmic solution versus the marketed benzalkonium chloride (BAK)-preserved latanoprost 50 μg/mL ophthalmic solution in patients with open-angle glaucoma and patients with ocular hypertension. Methods: This was a prospective, national, randomized, multi-center, observer-blind, parallel-group controlled clinical trial. Patients were randomized to receive either PF or BAK-preserved latanoprost once daily for 12 weeks. The primary endpoint was the change in intraocular pressure (IOP) at 8:00 AM in the affected eye between the end of the treatment (week 12) and the baseline (week 0). Secondary measurements were taken at weeks 2 and 6, with IOP being recorded at 8:00 AM, 12:00 PM, and 4:00 PM. Results: A total of 158 patients were included in the per protocol (PP) population (77 in the PF latanoprost treatment arm and 81 patients in the BAK-preserved latanoprost treatment arm). PF latanoprost was non-inferior to BAK-preserved latanoprost in reducing IOP at 8:00 AM in the study eye from the baseline (week 0) to the end of the treatment (week 12). The point estimate of the between-treatment difference was 0.1 mmHg (95% confidence interval: -0.646, 0.847). Mean between-group differences in IOP reduction from the baseline to each of the secondary measurements were also similar between the two treatment arms. The two treatments were well tolerated and had comparable adverse event profiles. Conclusions: PF latanoprost was non-inferior to BAK-preserved latanoprost in reducing IOP in patients with open-angle glaucoma or ocular hypertension. Both treatments were well tolerated.

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Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects

Journal of Ophthalmology ◽

10.1155/2019/7419470 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Shih-Chun Chao ◽

Shang-Jung Yang ◽

Hung-Chi Chen ◽

Chi-Chin Sun ◽

Chin-Hsin Liu ◽

...

Keyword(s):

Intraocular Pressure ◽

Visual Field ◽

Ganglion Cell ◽

Ocular Hypertension ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Control Group ◽

Ganglion Cell Complex ◽

Outer Retina ◽

Flow Area

Purpose. To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA). Methods. A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. The ophthalmic data including best-corrected visual acuity, spherical equivalent, intraocular pressure, central corneal thickness, central foveal thickness, visual field deviation, retinal nerve fiber layers thickness, and ganglion cell complex thickness were obtained from medical documents. For the macular area, the superficial vessel density (VD), deep VD, foveal avascular zone (FAZ), flow area of the outer retina, and flow area of the choriocapillaris were measured via OCTA and analyzed using the default vascular density analysis program in the same OCTA device. Results. A total of 70 eyes from 70 patients were analyzed in the current study. Significant differences in the intraocular pressure, central corneal thickness, visual field deviation, retinal fiber layer thickness, and ganglion cell complex thickness were observed in the patients in the glaucoma group at their last visits. The OAG and NTG groups evinced a lower superficial VD than did the control group, while the NTG group had a lower deep VD than the control group. The NTG group also had a larger FAZ than did the OHT group. The flow area of the outer retina in the OAG group was low relative to those of the OHT and control groups. No difference in choriocapillaris perfusion was observed among the groups. Conclusion. The OAG and NTG patients demonstrated impaired vasculature before significant disease development could be observed. Furthermore, the differences in macular circulation may be associated with differences in the courses of disease between the glaucoma and OHT patients.

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