THERAPEUTIC RE-ORIENTATION IN SOME DEPRESSIVE STATES: CLINICAL EVALUATION OF A NEW MONO-AMINE OXIDASE INHIBITOR (W-1544-A) (PHENELZINE (NARDIL)

1959 ◽  
Vol 116 (5) ◽  
pp. 429-434 ◽  
Author(s):  
WILLIAM FURST
Keyword(s):  
Clinical Evaluation ◽  
Amine Oxidase ◽  
Oxidase Inhibitor ◽  
Depressive States

Amitriptyline: A controlled trial in chronic depressive states

1962 ◽  
Vol 108 (457) ◽  
pp. 859-861 ◽  
Author(s):  
Andrew Skarbek ◽  
Daphne Smedberg
Keyword(s):  
Monoamine Oxidase ◽  
Chemical Structure ◽  
Monoamine Oxidase Inhibitor ◽  
Controlled Trial ◽  
Oxidase Inhibitor ◽  
Amitriptyline Hydrochloride ◽  
Depressive States

Amitriptyline hydrochloride is 5–(3 dimethylaminopropylidine)–dibenzo (a,d) (1,4) cycloheptadiene hydrochloride. Structurally it is not related to the hydrazines and is not a monoamine oxidase inhibitor. It bears some resemblance to the phenothiazines and its chemical structure is related to imipramine, in which the central seven numbered ring is azepine, nitrogen replacing the partially unsaturated carbon of the amitriptyline cycloheptadiene ring (Dorfman, 1960; Vernier, 1961).

EFFECT OF AN AMINE-OXIDASE INHIBITOR ON ARTERIAL AMMONIUM LEVELS IN LIVER DISEASE

The Lancet ◽  
1957 ◽  
Vol 269 (6983) ◽  
pp. 1332-1333 ◽  
Author(s):  
A.M. Dawson ◽  
Sheila Sherlock
Keyword(s):  
Liver Disease ◽  
Amine Oxidase ◽  
Oxidase Inhibitor

A Monoamine Oxidase Inhibitor (Niamid) in the Treatment of the Mentally Subnormal

1961 ◽  
Vol 107 (446) ◽  
pp. 115-118 ◽  
Author(s):  
T. S. Davies
Keyword(s):  
Monoamine Oxidase ◽  
Clinical Evaluation ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
The Past

A clinical evaluation of the effects of a recently introduced monoamine oxidase inhibitor, N - isonicotinoyl - N1—(β - N - benzylcarboxamido - ethyl) hydrazine (Niamid, Pfizer, Ltd.) on certain types of mentally subnormal patients has been carried out over the past year.

THE EFFECT OF 5-HYDROXYTRYPTAMINE AND OF AN AMINE OXIDASE INHIBITOR ON EXPERIMENTAL DECIDUOMATA IN MICE

1961 ◽  
Vol 23 (2) ◽  
pp. 209-215 ◽  
Author(s):  
D. LINDSAY ◽  
E. POULSON ◽  
J. M. ROBSON
Keyword(s):  
Monoamine Oxidase ◽  
Toxic Effect ◽  
Corpus Luteum ◽  
Amine Oxidase ◽  
Oxidase Inhibitor ◽  
Toxic Effects ◽  
Endocrine Activity ◽  
Direct Toxic Effect ◽  
Decidual Tissue ◽  
Decidual Reaction

SUMMARY Investigations were carried out to study the mechanism by which 5-hydroxytryptamine (5-HT) and monoamine oxidase inhibitors interfere with pregnancy, using the experimental decidual reaction in mice. The results suggest that both 5-HT and an amine oxidase inhibitor, HP. 1325 (2,2′-(p-phenylenedioxy)-di-(ethyl hydrazinium (1+) chloride)), interfere with the endocrine activity of the ovary, particularly the corpus luteum, since their toxic effects on deciduomata are reversed by progesterone. In addition, 5-HT also has a direct toxic effect on decidual tissue.

THREE AMINE-OXIDASE INHIBITOR DRUGS IN THE TREATMENT OF DEPRESSION

The Lancet ◽  
1961 ◽  
Vol 277 (7167) ◽  
pp. 17-18 ◽  
Author(s):  
A.H. Crisp ◽  
P. Hays ◽  
A. Carter
Keyword(s):  
Amine Oxidase ◽  
Oxidase Inhibitor ◽  
Treatment Of Depression

Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide

2005 ◽  
Vol 522 (1-3) ◽  
pp. 139-146 ◽  
Author(s):  
Virgile Visentin ◽  
Sandy Bour ◽  
Jérémie Boucher ◽  
Danielle Prévot ◽  
Philippe Valet ◽  
...  
Keyword(s):  
Amine Oxidase ◽  
Diabetic Rats ◽  
Oxidase Inhibitor

Volatile amine oxidase inhibitor from hydrazine derivatives

1964 ◽  
Vol 13 (4) ◽  
pp. 577-588 ◽  
Author(s):  
Mitchell Kory ◽  
E. Mingioli
Keyword(s):  
Amine Oxidase ◽  
Oxidase Inhibitor ◽  
Hydrazine Derivatives
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