A Critical Look at the Value of Biochemical Liver Function Tests with Special Reference to Discriminant Function Analysis

Author(s):  
D. N. Baron
1977 ◽  
Vol 23 (4) ◽  
pp. 627-630 ◽  
Author(s):  
Paul Phillip Sher

Abstract I evaluated the diagnostic value of routinely ordered liver-function tests in 175 biopsy-proven cases of hepatic disease by use of stepwise discriminant analysis. The tests studied—total and "direct" bilirubin, alkaline phosphatase, lactate dehydrogenase, and aspartate aminotrans-ferase—correctly classified 45-73% of cases, depending on the homogeneity of the diagnostic groups. Aspartate aminotransferase and alkaline phosphatase were the best discriminators. When all tests were used in the most ho-mogeneous groups (tumors, cirrhosis, and hepatitis), there was a stepwise improvement in diagnostic accuracy from 51 to 73%.


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