Diagnostic Effectiveness of Biochemical Liver-Function Tests, as Evaluated by Discriminant Function Analysis

1977 ◽  
Vol 23 (4) ◽  
pp. 627-630 ◽  
Author(s):  
Paul Phillip Sher
Keyword(s):  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Discriminant Analysis ◽  
Liver Function ◽  
Function Analysis ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Hepatic Disease ◽  
Stepwise Discriminant Analysis ◽  
Function Tests

Abstract I evaluated the diagnostic value of routinely ordered liver-function tests in 175 biopsy-proven cases of hepatic disease by use of stepwise discriminant analysis. The tests studied—total and "direct" bilirubin, alkaline phosphatase, lactate dehydrogenase, and aspartate aminotrans-ferase—correctly classified 45-73% of cases, depending on the homogeneity of the diagnostic groups. Aspartate aminotransferase and alkaline phosphatase were the best discriminators. When all tests were used in the most ho-mogeneous groups (tumors, cirrhosis, and hepatitis), there was a stepwise improvement in diagnostic accuracy from 51 to 73%.

scholarly journals New insights into vitamin D regulation: is there a role for alkaline phosphatase?

2021 ◽  
Author(s):  
G. Bellastella ◽  
L. Scappaticcio ◽  
M. Longo ◽  
R. Carotenuto ◽  
C. Carbone ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Liver Function ◽  
Significant Negative Correlation ◽  
Liver Function Tests ◽  
Bone Alkaline Phosphatase ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests ◽  
Group 2 ◽  
Group 1

Abstract Purpose The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity. To check what factors could interfere with the activity of vitamin D-25-hydroxylase and thus alter the 25-OHD concentrations, we looked for potential correlations between 25-OHD and results of liver function tests in healthy adults. Methods This single-centre study was retrospective and consisted of evaluating the correlations between 25-OHD and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bone alkaline phosphatase (BALP) in 349 healthy subjects aged from 18 to 65 years. In particular, in Group 1 (n = 119), we looked for correlations between 25OHD and all liver function tests and in Group 2 (n = 230) the correlation between 25OHD and BALP. Results In Group 1, we found no correlation between 25OHD and AST (r =  − 0.03; p = 0.8), ALT (r =  − 0.02; p = 0.91), GGT (r =  − 0.08; p = 0.68), direct bilirubin (r =  − 0.02; p = 0.89), indirect bilirubin (r =  − 0.24; p = 0.21), and total bilirubin (r =  − 0.24; p = 0.21) but one between 25OHD and ALP (r =  − 0.2; p = 0.007); in Group 2, we found a significant negative correlation between 25-OHD and BALP (r =  − 0.2; p = 0.0008). Conclusions The correlations that we found suggest that ALP and BALP might be involved in the regulation of vitamin D-25-hydroxylase activity, but further studies are mandatory to confirm our assumptions.

Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases

1983 ◽  
Vol 28 (2) ◽  
pp. 129-136 ◽  
Author(s):  
R. Ferraris ◽  
G. Colombatti ◽  
M. T. Fiorentini ◽  
R. Carosso ◽  
W. Arossa ◽  
...  
Keyword(s):  
Liver Function ◽  
Bile Acids ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Serum Bile Acids ◽  
Function Tests ◽  
Hepatobiliary Diseases

Assessment of liver function

2013 ◽  
pp. 193-205
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Lactate Dehydrogenase ◽  
Epithelial Cell ◽  
Liver Function ◽  
Liver Function Tests ◽  
Metabolic Function ◽  
Cell Integrity ◽  
Biliary Epithelial Cell ◽  
Function Tests ◽  
Elevated Lactate ◽  
Elevated Lactate Dehydrogenase

Interpretation of liver function tests Imaging Liver biopsy The patient with persistently deranged liver function tests but normal investigations Liver function tests (LFT) can be divided into markers of hepatocyte or biliary epithelial cell integrity (ALT, AST, ALP, γ‎GT), and those indicative of synthetic/metabolic function (albumin, INR/PTT, bilirubin, ammonia). In addition, hypoglycaemia, lactic acidosis, and elevated lactate dehydrogenase (LDH) can be non-specific markers of severe hepatic dysfunction....

scholarly journals Performance of a calculator for diagnosing the cause of liver damage

2019 ◽  
Vol 147 (1-2) ◽  
pp. 27-33
Author(s):  
Narcisa Petrovic-Subic ◽  
Miroslav Kojic ◽  
Slobodan Jankovic ◽  
Srdjan Stefanovic
Keyword(s):  
Liver Function ◽  
Liver Damage ◽  
Real Life ◽  
High Specificity ◽  
Liver Function Tests ◽  
Diagnostic Value ◽  
Abnormal Liver Function ◽  
Function Tests ◽  
Good Ability ◽  
Significant Difference

Introduction/Objective. Making a calculator that would recognize patterns of abnormal liver function tests and link them to the most probable etiology could help clinicians in their initial orientation towards a definitive diagnosis in patients with liver damage. The aim of our study was to design, construct, and validate a calculator that based on a pattern of abnormalities in liver function tests of a patient with liver damage would propose the most probable etiology. Methods. Patterns of abnormal liver function tests for certain etiology of liver damage were extracted from distributions of actual values taken from reports in medical literature about patients whose etiology of liver damage was proven by reliable diagnostic tests. After setting up the calculator with the patterns extracted, its diagnostic value was checked under real-life conditions, on a sample of patients with liver damage whose etiology was established by the gold standard of diagnostics (biopsy or else). The calculator validation study was carried out at the Military Medical Academy in Belgrade during a two-year period (2015?2016). Results. For all tested diagnoses, the calculator demonstrated a highly significant difference between the area under the receiver-operator curves? values and the value of 0.5 (p < 0.001), and high level of sensitivity (more than 90%, except for the model for chronic hepatitis) as well as relatively high specificity (more than 75%) were noted, indicating good ability of the calculator to detect etiology of liver damage. Conclusion. New calculators showed satisfactory sensitivity and specificity for revealing major liver damage etiologies.

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