Severe Salmonella Gastroenteritis Associated with Hypochlorhydria

1971 ◽  
Vol 16 (5) ◽  
pp. 255-258 ◽  
Author(s):  
J. A. Gray ◽  
Angela M. Trueman
Keyword(s):  
Gastric Juice ◽  
Pernicious Anaemia ◽  
Gastric Surgery ◽  
Aetiological Factor ◽  
Diarrheal Illness ◽  
Altered Physiology ◽  
Salmonella Enteritis ◽  
Seriously Ill

An unusually severe and prolonged salmonella enteritis is described in 6 adults; 5 had previously undergone gastric surgery and one had pernicious anaemia. Possible causes are discussed but the probable common aetiological factor was deficient gastric juice. Hypo- or achlorhydric subjects appear more prone to salmonellosis and may become seriously ill as a result. Any diarrheal illness in them should be investigated by the bacteriologist before being attributed to altered physiology alone.

An Evaluation of the Double Isotope Test in the Diagnosis of Pernicious Anaemia

1972 ◽  
Vol 17 (11) ◽  
pp. 359-363 ◽  
Author(s):  
R. W. Payne ◽  
R. D. Finney
Keyword(s):  
Oral Administration ◽  
Gastric Juice ◽  
Pernicious Anaemia ◽  
Diagnostic Value ◽  
The Other ◽  
Vitamin B ◽  
Human Gastric Juice ◽  
Control Subjects ◽  
Normal Human ◽  
Double Isotope

Urinary radioactivity following the simultaneous oral administration of Vitamin B12, labelled with 2 isotopes of cobalt (‘Dicopac’ test), was measured in 20 control subjects and in 20 patients suffering from pernicious anaemia: one isotope was bound to normal human gastric juice, while the other was free. The test was simple to perform and while the majority of results were of diagnostic value, some equivocal results were also obtained.

Tubeless tests for gastric acid

1964 ◽  
Vol 2 (23) ◽  
pp. 91-92
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Gastric Juice ◽  
False Negative ◽  
Pernicious Anaemia ◽  
Rheumatoid Disease ◽  
Negative Results ◽  
False Negative Results ◽  
Hypochromic Anaemia

Absence of gastric acid secretion (anacidity, pH of gastric juice 7 or over) or abnormally low gastric acid secretion (achlorhydria, pH of gastric juice between 3. 6 and 7, depending on the definition) is evidence of the atrophy of gastric mucosa which is always present in adults with pernicious anaemia, and often accompanies chronic hypochromic anaemia, rheumatoid disease, myxoedema, diabetes mellitus, aplastic anaemia, steatorrhoea, and gastric carcinoma; it also occurs in relatives of patients with pernicious anaemia. The only indication for the use of tubeless tests is to demonstrate gastric acid secretion, thus excluding the diagnosis of pernicious anaemia in an anaemic adult. The tests can reliably show that acid is present, but they cannot show conclusively that acid is absent: false negative results are not uncommon. 1–3 For this reason some consultants doubt whether these tests are worth using.

INTRINSIC-FACTOR ANTIBODIES IN GASTRIC JUICE OF PERNICIOUS-ANÆMIA PATIENTS

The Lancet ◽  
1966 ◽  
Vol 288 (7454) ◽  
pp. 88-89 ◽  
Author(s):  
JuneMarion Fisher ◽  
Carolyn Rees ◽  
KeithB Taylor
Keyword(s):  
Gastric Juice ◽  
Intrinsic Factor ◽  
Pernicious Anaemia

Hydroxocobalamin and cyanocobalamin

1966 ◽  
Vol 4 (3) ◽  
pp. 11-12
Keyword(s):  
Gastric Carcinoma ◽  
Oral Therapy ◽  
Bacterial Flora ◽  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Gastric Surgery ◽  
Vitamin B ◽  
Diphyllobothrium Latum ◽  
Temperate Climates

In temperate climates deficiency of vitamin B12 is usually due to defective absorption, most commonly from lack of intrinsic factor as in Addisonian pernicious anaemia and after gastric surgery; occasionally the absorptive defect is caused by gastric carcinoma, resection, short-circuiting or disease of the ileum, including an abnormal bacterial flora, or by the fish tapeworm (Diphyllobothrium latum). The effectiveness of oral therapy remains debatable,1 and, since the absorptive defect can rarely be corrected, injections of vitamin B12 are virtually essential.

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