Distributed multi-scale muscle simulation in a hybrid MPI–CUDA computational environment

SIMULATION ◽  
2015 ◽  
Vol 92 (1) ◽  
pp. 19-31 ◽  
Author(s):  
Miloš Ivanović ◽  
Boban Stojanović ◽  
Ana Kaplarević-Mališić ◽  
Richard Gilbert ◽  
Srboljub Mijailovich
Keyword(s):  
Multi Scale ◽  
Computational Environment ◽  
Muscle Simulation

scholarly journals Astroglial biophysics probed with a realistic cell model

2018 ◽  
Author(s):  
Leonid P. Savtchenko ◽  
Lucie Bard ◽  
Thomas P. Jensen ◽  
James P. Reynolds ◽  
Igor Kraev ◽  
...  
Keyword(s):  
Characteristic Length ◽  
Cell Model ◽  
Neural Circuitry ◽  
Scale Morphology ◽  
Proof Of Concept ◽  
Model Builder ◽  
Multi Scale ◽  
Computational Environment ◽  
Membrane Effects ◽  
Basic Features

Electrically non-excitable astroglia take up neurotransmitters, buffer extracellular K+ and generate Ca2+ signals that release molecular regulators of neural circuitry. The underlying machinery remains enigmatic, mainly because the nanoscopic, sponge-like astrocyte morphology has been difficult to access experimentally or explore theoretically. Here, we have systematically evaluated the multi-scale morphology of protoplasmic astroglia to construct a realistic multi-compartmental cell model that can be biophysically interrogated in NEURON computational environment. This approach has been implemented as an astrocyte-model builder ASTRO. As a proof of concept, we explored a hippocampal astrocyte reconstructed in silico against a battery of physiological and imaging experiments. This exploration has unveiled some basic features of astroglial physiology inaccessible empirically, such as the characteristic length of membrane voltage propagation, membrane effects of local glutamate transport, spatiotemporal dynamics of intracellular K+ redistribution, key Ca2+ buffering properties, and some basic relationships between free Ca2+ dynamics and experimental readout of fluorescent Ca2+ indicators.

ECG Classification with Multi-Scale Deep Features Based on Adaptive Beat-Segmentation

2020 ◽  
Vol E103.B (12) ◽  
pp. 1403-1410
Author(s):  
Huan SUN ◽  
Yuchun GUO ◽  
Yishuai CHEN ◽  
Bin CHEN
Keyword(s):  
Multi Scale
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