Thick corpus callosum: An underrecognised but important diagnostic clue

Tropical Doctor ◽

10.1177/00494755211026281 ◽

2021 ◽

pp. 004947552110262

Author(s):

Suchit S Jogu ◽

Bhanudeep Singanamalla ◽

Priyanka Madaan ◽

Chirag K Ahuja ◽

Lokesh Saini

Keyword(s):

Corpus Callosum ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

First Episode ◽

Common Disorder ◽

Diagnostic Clue ◽

Signal Intensities

Neurofibromatoses are inherited tumour-suppressive disorders that are characterised by multiple neoplastic and non-neoplastic tumours. Neurofibromatosis type 1 is a common disorder with multiple neurofibromas with widespread complications. We here report a seven-year old boy presenting with first episode of seizure and multiple café-au-lait macules but neuroimaging revealed corpus callosal changes without any focal areas of signal intensities.

Download Full-text

Neurofibromatosis type 1 (NF1) associated with tumor of the corpus callosum

Child s Nervous System ◽

10.1007/s00381-012-1903-9 ◽

2012 ◽

Vol 28 (12) ◽

pp. 2177-2180 ◽

Cited By ~ 2

Author(s):

Ignacio Pascual-Castroviejo ◽

Samuel-Ignacio Pascual-Pascual

Keyword(s):

Corpus Callosum ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type

Download Full-text

ED-31 * RECURRENT PILOCYTIC ASTROCYTOMA OF THE CORPUS CALLOSUM IN A PATIENT WITH NEUROFIBROMATOSIS TYPE 1

Neuro-Oncology ◽

10.1093/neuonc/nou253.31 ◽

2014 ◽

Vol 16 (suppl 5) ◽

pp. v72-v72

Author(s):

H. Tathireddy ◽

J. Lin ◽

M. Gujrati ◽

M. Zagardo ◽

K. Fernandez ◽

...

Keyword(s):

Corpus Callosum ◽

Neurofibromatosis Type 1 ◽

Pilocytic Astrocytoma ◽

Neurofibromatosis Type

Download Full-text

Effects of Age on White Matter Microstructure in Children With Neurofibromatosis Type 1

Journal of Child Neurology ◽

10.1177/08830738211008736 ◽

2021 ◽

pp. 088307382110087

Author(s):

Lydia T. Tam ◽

Nathan N. Ng ◽

Emily S. McKenna ◽

Lisa Bruckert ◽

Kristen W. Yeom ◽

...

Keyword(s):

Early Childhood ◽

White Matter ◽

Corpus Callosum ◽

Fractional Anisotropy ◽

Middle Childhood ◽

Neurofibromatosis Type 1 ◽

Neurofibromatosis Type ◽

Childhood And Adolescence ◽

White Matter Microstructure

Children with neurofibromatosis type 1 (NF1) often report cognitive challenges, though the etiology of such remains an area of active investigation. With the advent of treatments that may affect white matter microstructure, understanding the effects of age on white matter aberrancies in NF1 becomes crucial in determining the timing of such therapeutic interventions. A cross-sectional study was performed with diffusion tensor imaging from 18 NF1 children and 26 age-matched controls. Fractional anisotropy was determined by region of interest analyses for both groups over the corpus callosum, cingulate, and bilateral frontal and temporal white matter regions. Two-way analyses of variance were done with both ages combined and age-stratified into early childhood, middle childhood, and adolescence. Significant differences in fractional anisotropy between NF1 and controls were seen in the corpus callosum and frontal white matter regions when ages were combined. When stratified by age, we found that this difference was largely driven by the early childhood (1-5.9 years) and middle childhood (6-11.9 years) age groups, whereas no significant differences were appreciable in the adolescence age group (12-18 years). This study demonstrates age-related effects on white matter microstructure disorganization in NF1, suggesting that the appropriate timing of therapeutic intervention may be in early childhood.

Download Full-text