The Effects of Intravenous Administration of 10% Travamulsion Fat Emulsion to Beagle Dogs for 91 Consecutive Days

1983 ◽  
Vol 7 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Rodger S. Izzo ◽  
Nancy Leissing ◽  
Eugene Woods ◽  
William Remis ◽  
Martha Napoli ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs ◽  
Fat Emulsion

Effects of intravenous administration of a fat emulsion on blood coagulation in dogs

1959 ◽  
Vol 196 (5) ◽  
pp. 1015-1019 ◽  
Author(s):  
Harrison H. Shoulders ◽  
Robert C. Hartmann ◽  
H. C. Meng
Keyword(s):  
Blood Coagulation ◽  
Intravenous Administration ◽  
Intravenous Infusion ◽  
Bleeding Time ◽  
Plasma Fibrinogen ◽  
Fibrinogen Concentration ◽  
Clotting Time ◽  
Clot Retraction ◽  
Fat Emulsion ◽  
Abnormal Bleeding

A fat emulsion prepared for intravenous administration has been studied with regard to its effect upon blood coagulation in dogs. The most characteristic effects found during intravenous infusion of this material at a rate of 1 ml/min. were thrombocytopenia and marked shortening of clotting time. These effects were invariably observed in animals which had not previously received the emulsion. When subsequent infusions were given within 3 hours, no significant changes were observed. When the interval was extended to 1–13 days, variable responses occurred, at times characterized by pronounced hypocoagulability. If the repeat infusion was given 2 weeks or more after the initial one, the effects were similar to those observed during the first infusion. The prothrombin and thrombin clotting times and plasma fibrinogen concentration were not greatly altered during the infusion. Abnormal bleeding time, ‘prothrombin utilization’ and clot retraction accompanied the thrombocytopenia.

Effects of Intravenous Administration of Fat Emulsion on Formed Blood Elements and Body Temperature in Dogs

1956 ◽  
Vol 187 (1) ◽  
pp. 107-112 ◽  
Author(s):  
H. C. Meng ◽  
Hertha Cress ◽  
John B. Youmans
Keyword(s):  
Body Temperature ◽  
Olive Oil ◽  
Intravenous Administration ◽  
Rectal Temperature ◽  
Fat Emulsion ◽  
Oral Ingestion ◽  
Oil Emulsion ◽  
Heparin Administration ◽  
Healthy Dogs ◽  
Blood Elements

Intravenous administration of a 10% olive oil emulsion or lymph to healthy dogs anesthetized with Nembutal produced marked thrombocytopenia, leucopenia, neutropenia, eosinopenia, lymphopenia, increase in mechanical fragility of erythrocytes, and increase in hematocrit. The increase in mechanical fragility of erythrocytes correlated directly with the degree of lipemia. Heparin administration accelerated the removal of the injected fat from the circulation and hastened the return to normal of the formed blood elements. The changes in the formed blood elements were more marked and persisted longer in the dogs receiving piromen. The changes in the formed blood elements following oral ingestion of olive oil were either mild or insignificant except for the moderate eosinophilia. Elevation of rectal temperature and persistent lymphopenia were observed only in the animals receiving emulsion and piromen. It is concluded that the changes in formed blood elements, including the increase in mechanical fragility of erythrocytes following intravenous administration of fat emulsion, did not seem to correlate with the rise of body temperature.

Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs

2011 ◽  
Vol 42 (5) ◽  
pp. 578-583 ◽  
Author(s):  
Henrik Agersø ◽  
Niels Rode Kristensen ◽  
Henrik Østergaard ◽  
Ditte Maria Karpf ◽  
Mette Brunsgaard Hermit ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

scholarly journals Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs

Molecules ◽  
2014 ◽  
Vol 19 (1) ◽  
pp. 538-549
Author(s):  
Chih-Hsien Chang ◽  
Si-Yen Liu ◽  
Te-Wei Lee
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

Increased Lipoprotein X Causes Hyperlipidemia During Intravenous Administration of 10% Fat Emulsion in Man

1991 ◽  
Vol 15 (5) ◽  
pp. 546-550 ◽  
Author(s):  
Tsuguhiko Tashiro ◽  
Yoshiya Mashima ◽  
Hideo Yamamori ◽  
Kazuo Horibe ◽  
Masahiko Nishizawa ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Fat Emulsion

Fat emulsion vehicle for intravenous administration of an aqueous insoluble drug

1975 ◽  
Vol 32 (6) ◽  
pp. 582-584
Author(s):  
Clarence L. Fortner ◽  
William R. Grove ◽  
Donald Bowie ◽  
Michael D. Walker
Keyword(s):  
Intravenous Administration ◽  
Fat Emulsion

scholarly journals Role of mitochondrial and sarcolemmal KATPchannels in ischemic preconditioning of the canine heart

2001 ◽  
Vol 280 (1) ◽  
pp. H256-H263 ◽  
Author(s):  
Shoji Sanada ◽  
Masafumi Kitakaze ◽  
Hiroshi Asanuma ◽  
Kengo Harada ◽  
Hisakazu Ogita ◽  
...  
Keyword(s):  
Infarct Size ◽  
Intravenous Administration ◽  
Ischemic Preconditioning ◽  
Channel Blocker ◽  
Control Group ◽  
Canine Heart ◽  
Beagle Dogs ◽  
Left Anterior Descending Artery ◽  
Channel Opener

We tested whether mitochondrial or sarcolemmal ATP-sensitive K+(KATP) channels play a key role in ischemic preconditioning (IP) in canine hearts. In open-chest beagle dogs, the left anterior descending artery was occluded four times for 5 min each with 5-min intervals of reperfusion (IP), occluded for 90 min, and reperfused for 6 h. IP as well as cromakalim and nicorandil (nonspecific KATP channel openers) markedly limited infarct size (6.3 ± 1.2, 8.9 ± 1.9, and 7.2 ± 1.6%, respectively) compared with the control group (40.9 ± 4.1%). A selective mitochondrial KATP channel blocker, 5-hydroxydecanoate, partially blunted the limitation of infarct size in the animals subjected to IP and those treated with cromakalim and nicorandil (21.6 ± 3.8, 25.1 ± 4.6, and 19.8 ± 5.2%, respectively). A nonspecific KATP channel blocker, glibenclamide, completely abolished the effect of IP (38.5 ± 6.2%). Intracoronary or intravenous administration of a mitochondria-selective KATP channel opener, diazoxide, at >100 μmol/l could only partially decrease infarct size (19.5 ± 4.3 and 20.1 ± 4.4%, respectively). In conclusion, mitochondrial and sarcolemmal KATP channels independently play an important role in the limitation of infarct size by IP in the canine heart.

New Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle Dogs

2020 ◽  
Vol 109 (6) ◽  
pp. 2090-2094 ◽  
Author(s):  
Max Sauter ◽  
Philipp Uhl ◽  
Andreas D. Meid ◽  
Gerd Mikus ◽  
Jürgen Burhenne ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs
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