scholarly journals Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs

Molecules ◽  
2014 ◽  
Vol 19 (1) ◽  
pp. 538-549
Author(s):  
Chih-Hsien Chang ◽  
Si-Yen Liu ◽  
Te-Wei Lee
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs

2011 ◽  
Vol 42 (5) ◽  
pp. 578-583 ◽  
Author(s):  
Henrik Agersø ◽  
Niels Rode Kristensen ◽  
Henrik Østergaard ◽  
Ditte Maria Karpf ◽  
Mette Brunsgaard Hermit ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

The Effects of Intravenous Administration of 10% Travamulsion Fat Emulsion to Beagle Dogs for 91 Consecutive Days

1983 ◽  
Vol 7 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Rodger S. Izzo ◽  
Nancy Leissing ◽  
Eugene Woods ◽  
William Remis ◽  
Martha Napoli ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs ◽  
Fat Emulsion

scholarly journals Role of mitochondrial and sarcolemmal KATPchannels in ischemic preconditioning of the canine heart

2001 ◽  
Vol 280 (1) ◽  
pp. H256-H263 ◽  
Author(s):  
Shoji Sanada ◽  
Masafumi Kitakaze ◽  
Hiroshi Asanuma ◽  
Kengo Harada ◽  
Hisakazu Ogita ◽  
...  
Keyword(s):  
Infarct Size ◽  
Intravenous Administration ◽  
Ischemic Preconditioning ◽  
Channel Blocker ◽  
Control Group ◽  
Canine Heart ◽  
Beagle Dogs ◽  
Left Anterior Descending Artery ◽  
Channel Opener

We tested whether mitochondrial or sarcolemmal ATP-sensitive K+(KATP) channels play a key role in ischemic preconditioning (IP) in canine hearts. In open-chest beagle dogs, the left anterior descending artery was occluded four times for 5 min each with 5-min intervals of reperfusion (IP), occluded for 90 min, and reperfused for 6 h. IP as well as cromakalim and nicorandil (nonspecific KATP channel openers) markedly limited infarct size (6.3 ± 1.2, 8.9 ± 1.9, and 7.2 ± 1.6%, respectively) compared with the control group (40.9 ± 4.1%). A selective mitochondrial KATP channel blocker, 5-hydroxydecanoate, partially blunted the limitation of infarct size in the animals subjected to IP and those treated with cromakalim and nicorandil (21.6 ± 3.8, 25.1 ± 4.6, and 19.8 ± 5.2%, respectively). A nonspecific KATP channel blocker, glibenclamide, completely abolished the effect of IP (38.5 ± 6.2%). Intracoronary or intravenous administration of a mitochondria-selective KATP channel opener, diazoxide, at >100 μmol/l could only partially decrease infarct size (19.5 ± 4.3 and 20.1 ± 4.4%, respectively). In conclusion, mitochondrial and sarcolemmal KATP channels independently play an important role in the limitation of infarct size by IP in the canine heart.

New Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle Dogs

2020 ◽  
Vol 109 (6) ◽  
pp. 2090-2094 ◽  
Author(s):  
Max Sauter ◽  
Philipp Uhl ◽  
Andreas D. Meid ◽  
Gerd Mikus ◽  
Jürgen Burhenne ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

Simultaneous determination of rabeprazole enantiomers and their four metabolites after intravenous administration in beagle dogs by a stereoselective HPLC-MS/MS method and its application in pharmacokinetic studies

2016 ◽  
Vol 8 (6) ◽  
pp. 1405-1414 ◽  
Author(s):  
Na Cao ◽  
Lei Liu ◽  
Yuan-bin Hao ◽  
Li-li Sun ◽  
Qiao-gen Zou ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Intravenous Administration ◽  
Pharmacokinetic Studies ◽  
Beagle Dogs ◽  
Beagle Dog

A sensitive, rapid and stable HPLC-MS/MS method has been developed and validated for the determination of rabeprazole enantiomers and their four metabolites in beagle dog.

Pharmacokinetics of forsythoside after intravenous administration in beagle dogs

2009 ◽  
Vol 34 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Rong Shi ◽  
Zhenyu Xuan ◽  
Yueming Ma ◽  
Yingying Liu ◽  
Hongguo Lu ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs

Fractionated intravenous administration of 90Y-labeled B72.3 GYK-DTPA immunoconjugate in beagle dogs

1993 ◽  
Vol 20 (5) ◽  
pp. 571-578 ◽  
Author(s):  
Huibert M. Vriesendorp ◽  
Y. Shao ◽  
Julia E. Blum ◽  
Syed M. Quadri ◽  
Jerry R. Williams
Keyword(s):  
Intravenous Administration ◽  
Beagle Dogs
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