Psychomotor effects, pharmacokinetics and safety of the orexin receptor antagonist suvorexant administered in combination with alcohol in healthy subjects

2015 ◽  
Vol 29 (11) ◽  
pp. 1159-1169 ◽  
Author(s):  
Hong Sun ◽  
Ka Lai Yee ◽  
Sean Gill ◽  
Wen Liu ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Healthy Subjects ◽  
Psychomotor Effects

Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects

2015 ◽  
Vol 55 (10) ◽  
pp. 1093-1100 ◽  
Author(s):  
Naoto Uemura ◽  
Jacqueline McCrea ◽  
Hong Sun ◽  
Mardik Donikyan ◽  
Gary Zammit ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Healthy Subjects

Bombesin Reduces Food Intake after a Preload in Man by a Cholecystokinin-Independent Mechanism

1993 ◽  
Vol 85 (3) ◽  
pp. 277-280 ◽  
Author(s):  
R. J. Lieverse ◽  
J. B. M. J. Jansen ◽  
A. A. M. Masclee ◽  
C. B. H. W. Lamers
Keyword(s):  
Food Intake ◽  
Receptor Antagonist ◽  
Healthy Subjects ◽  
Saline Infusion ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Cholecystokinin Receptor ◽  
Independent Mechanism

1. A double-blind study was undertaken to determine whether the infusion of bombesin inhibits the intake of a carbohydrate-rich meal, consumed 15 min after a 300 ml banana shake, in nine lean healthy subjects and whether the possible inhibition of food intake by bombesin is mediated by cholecystokinin. 2. The amount of food eaten during infusion of bombesin (267 ±60 g) and bombesin combined with the cholecystokinin-receptor antagonist loxiglumide (269±39g) was slightly (P = 0.09) less than during saline infusion (384 ± 40 g). In addition, preprandial feelings of hunger were significantly less during infusion of both bombesin and bombesin combined with loxiglumide. 3. In conclusion, infusion of bombesin tends to inhibit the intake of a carbohydrate-rich meal after a preload by a cholecystokinin-independent mechanism.

Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects

Xenobiotica ◽  
2019 ◽  
Vol 50 (4) ◽  
pp. 427-434 ◽  
Author(s):  
Mike Ufer ◽  
Christine Huynh ◽  
Jan Jaap van Lier ◽  
Eva Caroff ◽  
Hartmut Fischer ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Healthy Subjects ◽  
Subcutaneous Administration ◽  
P2y12 Receptor ◽  
P2y12 Receptor Antagonist
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