Bombesin Reduces Food Intake after a Preload in Man by a Cholecystokinin-Independent Mechanism

1993 ◽  
Vol 85 (3) ◽  
pp. 277-280 ◽  
Author(s):  
R. J. Lieverse ◽  
J. B. M. J. Jansen ◽  
A. A. M. Masclee ◽  
C. B. H. W. Lamers
Keyword(s):  
Food Intake ◽  
Receptor Antagonist ◽  
Healthy Subjects ◽  
Saline Infusion ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Cholecystokinin Receptor ◽  
Independent Mechanism

1. A double-blind study was undertaken to determine whether the infusion of bombesin inhibits the intake of a carbohydrate-rich meal, consumed 15 min after a 300 ml banana shake, in nine lean healthy subjects and whether the possible inhibition of food intake by bombesin is mediated by cholecystokinin. 2. The amount of food eaten during infusion of bombesin (267 ±60 g) and bombesin combined with the cholecystokinin-receptor antagonist loxiglumide (269±39g) was slightly (P = 0.09) less than during saline infusion (384 ± 40 g). In addition, preprandial feelings of hunger were significantly less during infusion of both bombesin and bombesin combined with loxiglumide. 3. In conclusion, infusion of bombesin tends to inhibit the intake of a carbohydrate-rich meal after a preload by a cholecystokinin-independent mechanism.

Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans

2001 ◽  
Vol 280 (4) ◽  
pp. R1149-R1154 ◽  
Author(s):  
Christoph Beglinger ◽  
Lukas Degen ◽  
Daniel Matzinger ◽  
Massimo D'Amato ◽  
Jürgen Drewe
Keyword(s):  
Food Intake ◽  
Receptor Antagonist ◽  
Eating Behavior ◽  
Healthy Subjects ◽  
Calorie Intake ◽  
Receptor Blockade ◽  
Double Blind ◽  
Fluid Ingestion ◽  
Crossover Studies

Exogenous cholecystokinin (CCK) induces early satiety when infused into humans. Whether alimentary CCK (CCK-A) receptor blockade stimulates food intake in humans is, however, uncertain. The aim of the present investigation was, therefore, to establish the effect of CCK-A receptor blockade on satiety and eating behavior in healthy volunteers. To further explore the role of endogenous CCK, the effects of the specific CCK-A receptor antagonist loxiglumide (Lox; 22 μmol · kg−1 · h−1) on satiety and eating behavior were investigated in healthy men and compared with saline infusions (as placebo) in a series of randomized, double-blind, placebo-controlled, crossover studies. Lox produced a slight (7%), but not significant ( P = 0.104), increase in food intake that was accompanied by a modest (10%), but significant ( P < 0.004), increase in calorie intake. Fluid ingestion was not affected by Lox. Subjects experienced more hunger and delayed fullness during Lox infusion than during saline infusion ( P < 0.05). This study provides further evidence that CCK is an endogenous physiological satiety signal acting through CCK-A receptor-mediated mechanisms. Repeated-dose studies comparing hunger and satiety responses after CCK-A receptor blockade in healthy subjects and patients with eating disorders may help clarify the possible involvement of endogenous CCK in these conditions.

scholarly journals A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Masako Nishiwaki ◽  
Miho Takayama ◽  
Hiroyoshi Yajima ◽  
Morihiro Nasu ◽  
Joel Park ◽  
...  
Keyword(s):  
General Hospital ◽  
Healthy Subjects ◽  
Massachusetts General Hospital ◽  
Blind Study ◽  
Double Blind Study ◽  
Insertion Depth ◽  
Double Blind ◽  
Acupuncture Sensation

To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly administered at various insertion depths (5 and 10 mm for the penetrating needles and 1 and 2 mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations in the Massachusetts General Hospital Acupuncture Sensation Scale (MASS), “heaviness” was the strongest and most frequently reported sensation with the 10 mm needles, but not with the 5 mm needles. There were no significant differences in number of sensations elicited, MASS index, range of spreading, and intensity of needle pain for 5 mm penetration versus 1 mm skin press and 10 mm penetration versus 2 mm skin press. The MASS index with 2 mm skin-touch needles was significantly larger than that with 1 mm skin-touch and 5 mm penetrating needles. The factor structures in the 12 acupuncture sensations between penetrating and skin-touch needles were different. The acupuncture sensations obtained in this study under satisfactorily performed double-blind (practitioner–patient) conditions suggest that a slight difference in insertion depth and skin press causes significant differences in quantity and quality of acupuncture sensations.

scholarly journals Effect of psyllium on gastric emptying, hunger feeling and food intake in normal volunteers: a double blind study

1998 ◽  
Vol 52 (4) ◽  
pp. 239-245 ◽  
Author(s):  
D Rigaud ◽  
F Paycha ◽  
A Meulemans ◽  
M Merrouche ◽  
M Mignon
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Normal Volunteers

Randomized, Double-Blind Study of SR142801 (Osanetant). A Novel Neurokinin-3 (NK3) Receptor Antagonist in Panic Disorder with Pre- and Posttreatment Cholecystokinin Tetrapeptide (CCK-4) Challenges

2005 ◽  
Vol 38 (01) ◽  
pp. 24-29 ◽  
Author(s):  
G. Kronenberg ◽  
P. Berger ◽  
R. Tauber ◽  
B. Bandelow ◽  
V. Henkel ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Receptor Antagonist ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Nk3 Receptor

Effect of Two Weeks of rTMS on Brain Activity in Healthy Subjects During an n-Back Task: A Randomized Double Blind Study

2013 ◽  
Vol 6 (4) ◽  
pp. 569-575 ◽  
Author(s):  
Christian Gaudeau-Bosma ◽  
Virginie Moulier ◽  
Anne-Camille Allard ◽  
Djedia Sidhoumi ◽  
Noomane Bouaziz ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Brain Activity ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Back Task

Benzodiazepihe-Receptor Antagonist, A Clinical Double Blind Study

1988 ◽  
Vol 26 (5-6) ◽  
pp. 283-292 ◽  
Author(s):  
H. P. Aarseth ◽  
J. E. Bredesen ◽  
B. Grynne ◽  
P. T. Lyngdal ◽  
L. Storstein ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind
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