CT, MRI, and18F-FDG PET/CT findings of malignant peripheral nerve sheath tumor of the head and neck

Malignant peripheral nerve sheath tumor (MPNST) is a malignant soft tissue sarcoma with high mortality, low morbidity, and poor prognosis. The MPNST occurs mostly in the limbs and torso, and rarely in the head and neck. However, MPNST is insensitive to radiotherapy and chemotherapy, and complete surgical resection with negative margin is the most important and effective strategy. We present a case of MPNST in the head and neck. The tumor invades the left temporal bone, petrous bone, and mastoid bone, and compression changes in the focal cerebellum and sigmoid sinus. The patient underwent the left temporal region tumor resection + surgical reconstruction with temporalis muscle flap and pectoralis major myocutaneous flap. Adjuvant radiotherapy (55 Gy) was given after surgery, and there were no local recurrence and distant metastasis after 31-month follow-up.

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Malignant Peripheral Nerve Sheath Tumor of Head and Neck

Diagnostic Imaging: Head and Neck ◽

10.1016/b978-0-323-44301-2.50124-5 ◽

2017 ◽

pp. 370-371

Keyword(s):

Peripheral Nerve ◽

Head And Neck ◽

Nerve Sheath Tumor ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath

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Diagnostic value of 18F-FDG PET-CT in detecting malignant peripheral nerve sheath tumors among adult and pediatric neurofibromatosis type 1 patients

Journal of Neuro-Oncology ◽

10.1007/s11060-021-03936-y ◽

2022 ◽

Author(s):

Ritch T. J. Geitenbeek ◽

Enrico Martin ◽

Laura H. Graven ◽

Martijn P. G. Broen ◽

Monique H. M. E. Anten ◽

...

Keyword(s):

Peripheral Nerve ◽

Fdg Pet ◽

Diagnostic Algorithm ◽

Threshold Value ◽

Threshold Values ◽

Nerve Sheath Tumors ◽

Peripheral Nerve Sheath Tumors ◽

Nerve Sheath ◽

Pet Ct ◽

Fdg Pet Ct

Abstract Purpose Detecting malignant peripheral nerve sheath tumors (MPNSTs) remains difficult. 18F-FDG PET-CT has been shown helpful, but ideal threshold values of semi-quantitative markers remain unclear, partially because of variation among scanners. Using EU-certified scanners diagnostic accuracy of ideal and commonly used 18F-FDG PET-CT thresholds were investigated and differences between adult and pediatric lesions were evaluated. Methods A retrospective cohort study was performed including patients from two hospitals with a clinical or radiological suspicion of MPNST between 2013 and 2019. Several markers were studied for ideal threshold values and differences among adults and children. A diagnostic algorithm was subsequently developed. Results Sixty patients were included (10 MPNSTs). Ideal threshold values were 5.8 for SUVmax (sensitivity 0.70, specificity 0.92), 5.0 for SUVpeak (sensitivity 0.70, specificity 0.97), 1.7 for TLmax (sensitivity 0.90, specificity 0.86), and 2.3 for TLmean (sensitivity 0.90, specificity 0.79). The standard TLmean threshold value of 2.0 yielded a sensitivity of 0.90 and specificity of 0.74, while the standard SUVmax threshold value of 3.5 yielded a sensitivity of 0.80 and specificity of 0.63. SUVmax and adjusted SUV for lean body mass (SUL) were lower in children, but tumor-to-liver ratios were similar in adult and pediatric lesions. Using TLmean > 2.0 or TLmean < 2.0 and SUVmax > 3.5, a sensitivity and specificity of 1.00 and 0.63 can be achieved. Conclusion 18F-FDG PET-CT offers adequate accuracy to detect MPNSTs. SUV values in pediatric MPNSTs may be lower, but tumor-to-liver ratios are not. By combining TLmean and SUVmax values, a 100% sensitivity can be achieved with acceptable specificity.

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Malignant peripheral nerve sheath tumor of anterior abdominal wall- A rare presentation

IP Journal of Surgery and Allied Sciences ◽

10.18231/j.jsas.2021.018 ◽

2021 ◽

Vol 3 (3) ◽

pp. 81-83

Author(s):

Benny P B ◽

T A Vasu ◽

Illakia Selvan ◽

Anjali Rajan

Keyword(s):

Early Diagnosis ◽

Peripheral Nerve ◽

Head And Neck ◽

Abdominal Wall ◽

Malignant Tumors ◽

Anterior Abdominal Wall ◽

Nerve Sheath Tumor ◽

Rare Presentation ◽

Peripheral Nerve Sheath Tumor ◽

Nerve Sheath

Malignant peripheral nerve sheath tumor is highly malignant tumors that occur most commonly in head and neck as well as extremities. Very rarely it seen in the retroperitoneum. When associated with neurofibromatosis, they are having a poor outcome. We present a case malignant peripheral nerve sheath tumor of anterior abdominal wall. The location and rapid increase in size of the swelling permitted early diagnosis and treatment.

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