Dihydroartemisinin Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in HepG2 Human Hepatoma Cells

2011 ◽  
Vol 97 (6) ◽  
pp. 771-780 ◽  
Author(s):  
Xiaoling Gao ◽  
Ziguo Luo ◽  
Tingxiu Xiang ◽  
Kejian Wang ◽  
Jian Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

2012 ◽  
Vol 52 (3) ◽  
pp. 322-331 ◽  
Author(s):  
Lixia Zha ◽  
Lulu Fan ◽  
Guoping Sun ◽  
Hua Wang ◽  
Tai Ma ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induced Apoptosis

Effects of the antianginal drug fendiline on Ca2+ movement in hepatoma cells

2001 ◽  
Vol 20 (7) ◽  
pp. 359-364 ◽  
Author(s):  
J-S Cheng ◽  
J-L Wang ◽  
Y-K Lo ◽  
K-J Chou ◽  
K-C Lee ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Phospholipase C ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Independent Manner ◽  
Fura 2 ◽  
Inositol 1,4,5 Trisphosphate

This study investigated the effect of the anti-anginal drug, fendiline, on intracellular free Ca2+ levels ([Ca2+]i)inHA/ 22 human hepatoma cells by using fura-2 as a fluorescent Ca2+ dye. Fendiline (1-100 μM) increased [Ca2+]i with an EC50 of 25 μM. Removal of extracellular Ca2+ reduced the [Ca2+]i signals by 51-5%. Fendiline (10 μM)-induced Ca2+release was abolished by pretreatment with 1 μM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor). Inhibition of phospholipase C with 2 μM 1-(6-((17β 3 methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H pyrrole-2,5-dione (U73122) did not alter 10 μM fendilineinducedCa2+ release.Severalothercalmodulinantagonists, such as phenoxybenzamine (100-200 μM), trifluoperazine (5-50 μM),andfluphenazine N-chloroethane(2-100 μM), hadno effect on[Ca2+]i. Together, it wasfound that fendiline increased [Ca2+]i in human hepatoma cells by discharging Ca2+ from the endoplasmic reticulum in an inositol 1,4,5 trisphosphate-independent manner and by inducing Ca2+entry. This effect of fendiline does not appear to be via antagonism of calmodulin.

Bitter orange peel extract induces endoplasmic reticulum-mediated autophagy in human hepatoma cells

2019 ◽  
Vol 60 ◽  
pp. 103404 ◽  
Author(s):  
Kuan-Hung Lu ◽  
Huey-Yin Lee ◽  
Yung-Lin Chu ◽  
Chi-Tang Ho ◽  
Lee-Yan Sheen
Keyword(s):  
Endoplasmic Reticulum ◽  
Orange Peel ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Bitter Orange ◽  
Orange Peel Extract ◽  
Peel Extract
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