Familial synchronous bilateral teratoid Wilms tumor with elevated alpha-fetoprotein level

2012 ◽  
Vol 98 (6) ◽  
pp. e179-e182 ◽  
Author(s):  
Arzu Okur ◽  
Faruk Guclu Pinarli ◽  
Ceyda Karadeniz ◽  
Aylar Poyraz ◽  
Kibriya Fidan ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Age Of Onset ◽  
Wilms Tumor ◽  
Alpha Fetoprotein ◽  
Rare Entity ◽  
Rare Type ◽  
Specific Tumor ◽  
Serum Alpha Fetoprotein ◽  
First Time ◽  
Specific Tumor Marker

Familial Wilms tumor is a rare entity that accounts for only 1–2% of all Wilms tumor cases, with an earlier age of onset and an increased frequency of bilateral tumors. Teratoid Wilms tumor is a variant of nephroblastoma with a predominance of heterologous tissues comprising more than 50% of the tumor volume. Wilms tumor does not usually secrete any specific tumor marker and all teratoid Wilms tumor cases previously reported were sporadic non-secreting neoplasms. Here we describe an infant with familial synchronous bilateral teratoid Wilms tumor whose serum alpha-fetoprotein level was elevated. To our knowledge, this extremely rare type of case is reported for the first time in the literature.

Hepatoid adenocarcinoma of the lung and the review of the literature

2020 ◽  
Vol 26 (6) ◽  
pp. 1505-1510
Author(s):  
Onder Tonyali ◽  
Onur Gonullu ◽  
Mehmet Akif Ozturk ◽  
Aysun Kosif ◽  
Ozlenen Gonca Civi
Keyword(s):  
Concurrent Chemoradiotherapy ◽  
Mediastinal Lymph Node ◽  
Alpha Fetoprotein ◽  
Disease Stage ◽  
Hepatoid Adenocarcinoma ◽  
Rare Type ◽  
Adenocarcinoma Of The Lung ◽  
Female Smoker ◽  
Diagnostic Biopsy ◽  
Serum Alpha Fetoprotein

Introduction Hepatoid adenocarcinoma of the lung is an extremely rare type of the non-small cell lung cancer. Treatment principles and prognosis are similar to that of lung adenocarcinoma. Case report A 62-year-old female smoker presented with a huge mass in the left upper lobe. After diagnostic biopsy, she underwent left pneumonectomy and mediastinal lymph node dissection. A diagnosis of stage T4N1M0 hepatoid adenocarcinoma of the lung with positive surgical margins was made. Management and outcome After the operation, the level of serum alpha fetoprotein was 9010 ng/ml (N: <10). The level of serum alpha fetoprotein was decreased with concurrent chemoradiotherapy and chemotherapy. Disease progression was detected at 11 months after diagnosis. No response was obtained to other therapies. The patient died at 14 months from the time of diagnosis. Discussion Usually, patients with hepatoid adenocarcinoma of the lung are male smokers. Hepatoid adenocarcinoma tends to settle in the upper lobes of the lung. The most important prognostic factor of the hepatoid adenocarcinoma of the lung is the disease stage at the diagnosis and patients with metastatic disease have poor survival.

scholarly journals Sacrococcygeal teratoma with intradural extension: case report

2015 ◽  
Vol 15 (4) ◽  
pp. 380-383 ◽  
Author(s):  
Shima Shahjouei ◽  
Sara Hanaei ◽  
Farideh Nejat ◽  
Maryam Monajemzadeh ◽  
Mostafa El Khashab
Keyword(s):  
Case Report ◽  
Alpha Fetoprotein ◽  
Sacrococcygeal Teratoma ◽  
Rare Entity ◽  
Imaging Findings ◽  
Healthy Neonate ◽  
Serum Alpha Fetoprotein ◽  
Teratoma Formation ◽  
High Level

Intradural sacrococcygeal teratoma (SCT) is a rare entity that has been reported in only a few cases previously. The authors present the case of a 2-week-old, otherwise healthy neonate with a mass in the buttock. The imaging findings and the high level of serum alpha-fetoprotein were highly suggestive of SCT. On operation the authors found intradural extension of the teratoma. The lesion was managed successfully without any remaining sequelae. The authors briefly review the currently proposed etiology regarding teratoma formation and the intradural extension of SCT.

scholarly journals On-treatment alpha-fetoprotein is a specific tumor marker for hepatocellular carcinoma in patients with chronic hepatitis B receiving entecavir

Hepatology ◽  
2014 ◽  
Vol 59 (3) ◽  
pp. 986-995 ◽  
Author(s):  
Grace L.H. Wong ◽  
Henry L.Y. Chan ◽  
Yee-Kit Tse ◽  
Hoi-Yun Chan ◽  
Chi-Hang Tse ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Tumor Marker ◽  
Chronic Hepatitis B ◽  
Alpha Fetoprotein ◽  
Specific Tumor ◽  
Specific Tumor Marker

A TERATOID WILMS' TUMOR WITH RAISED SERUM ALPHA-FETOPROTEIN LEVEL

1996 ◽  
Vol 16 (5) ◽  
pp. 853-859 ◽  
Author(s):  
M. T. Ashworth ◽  
B. L. Pizer ◽  
A. Oakhill ◽  
R. D. Spicer ◽  
P. J. Berry
Keyword(s):  
Wilms Tumor ◽  
Alpha Fetoprotein ◽  
Serum Alpha Fetoprotein

scholarly journals Early Detection of Hepatocellular Carcinoma Recurrence Using the Highly Sensitive Fucosylated Fraction of Alpha-Fetoprotein

2017 ◽  
Vol 11 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Toru Setsu ◽  
Atsunori Tsuchiya ◽  
Takayuki Watanabe ◽  
Takuro Nagoya ◽  
Satoshi Ikarashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Detection ◽  
Alpha Fetoprotein ◽  
Curative Treatment ◽  
Specific Tumor ◽  
Highly Sensitive ◽  
Novel Method ◽  
Hepatocellular Carcinoma Recurrence ◽  
Specific Tumor Marker ◽  
Hcc Recurrence

Alpha-fetoprotein (AFP)-L3 was originally reported as a hepatocellular carcinoma (HCC)-specific tumor marker, and recent accumulation of evidence has revealed that AFP-L3 frequency predicts the biological malignancy potential of HCC. However, AFP-L3 elevation from undetectable levels after curative treatment could not be discussed due to the difficulties of calculating AFP-L3 concentrations when serum AFP levels were low. Here, as a novel method, we used highly sensitive AFP-L3 frequency to predict HCC recurrence after curative treatment. Our cases illustrate that recognizing elevation of AFP-L3 from undetectable levels led to the early detection of recurrent HCC due to more careful surveillance.

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