Zollinger-Ellison Syndrome in Three Dogs

The main clinical signs of three dogs with Zollinger-Ellison syndrome were vomiting, diarrhoea, poor appetite and weight loss. The diagnosis was confirmed by histological examination and by gastrin immunocytochemistry. Gastrin was extracted from pancreatic tumours of two dogs. Gastrin-component III predominated in one dog while gastrin-compo-nent II and gastrin-component III were demonstrated in almost equal amounts in the other dog. In one dog serum gastrin concentration was high. Postmortem examination revealed pancreatic tumours in all three dogs and metastases in the regional lymph nodes and liver in two. The pancreatic tumours contained three patterns of growth: solid, trabecular and acinar. Electron microscopy of liver metastases showed cells with secretory granules. In all three dogs there was an erosive oesophagitis and thick gastric mucosa caused mainly by glandular proliferation. Two dogs had erosions and ulcers in the duodenum, one also in the first part of the jejunum. Villous atrophy and cellular infiltration of the duodenal mucosa were found in all dogs.

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Relationship Between Lower Esophageal Sphincter Pressure and Serum Gastrin Concentration in Zollinger-Ellison Syndrome and Other Clinical Settings

Gastroenterology ◽

10.1016/s0016-5085(79)80131-6 ◽

1979 ◽

Vol 76 (1) ◽

pp. 76-81 ◽

Cited By ~ 19

Author(s):

Richard W. McCallum ◽

John H. Walsh

Keyword(s):

Lower Esophageal Sphincter ◽

Serum Gastrin ◽

Lower Esophageal Sphincter Pressure ◽

Clinical Settings ◽

Sphincter Pressure ◽

Zollinger Ellison Syndrome ◽

Serum Gastrin Concentration ◽

Esophageal Sphincter

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Primary hepatic gastrinoma being diagnosed preoperatively: a case report and literature review

Surgical Case Reports ◽

10.1186/s40792-020-01072-9 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Shunya Hanzawa ◽

Hiroshi Sadamori ◽

Masaaki Kagoura ◽

Kazuteru Monden ◽

Masayoshi Hioki ◽

...

Keyword(s):

Serum Gastrin ◽

Somatostatin Receptor ◽

Gastrin Level ◽

Serum Gastrin Level ◽

Cystic Degeneration ◽

Hepatic Lobectomy ◽

Zollinger Ellison Syndrome ◽

Right Hepatic Lobectomy ◽

Serum Gastrin Concentration ◽

Primary Hepatic Gastrinoma

Abstract Background A majority of gastrinomas causing Zollinger–Ellison syndrome are located in the duodenum or pancreas. Primary hepatic gastrinomas are rare and difficult to diagnose. We report a rare case of primary hepatic gastrinoma, which could be diagnosed preoperatively. Case presentation A 29-year-old man with a 55-mm tumor in segments 5 and 6 (S 5/6) of the liver was admitted to our hospital. After thorough investigations, he was treated for a suspected inflammatory pseudotumor and advised to undergo routine follow-up. Two years later, he revisited our hospital with a complaint of abdominal pain, vomiting, and diarrhea. Upper gastrointestinal endoscopy revealed multiple duodenal ulcers. His serum gastrin level was 2350 pg/mL (normal: 37–172 pg/mL), suggesting Zollinger–Ellison syndrome. Abdominal computed tomography showed a 78-mm hypervascular tumor with cystic degeneration in the S 5/6 region of the liver, with a potential to increase over time. The tumor showed hypointensity on T2-weighted and hyperintensity on diffusion-weighted abdominal contrast-enhanced magnetic resonance imaging. Somatostatin receptor scintigraphy (SRS) only detected a hepatic tumor. No tumors in the gastrinoma triangle were detected by endoscopic ultrasonography. Hence, selective arterial calcium injection (SACI) test was performed to determine the location of the gastrinoma. The serum gastrin concentration increased from 4620 pg/mL to 23,600 pg/mL at 20 s after calcium gluconate injection into the proper hepatic artery. Conversely, no effect on serum gastrin level was observed after the injection into any other arteries. Extended right hepatic lobectomy and cholecystectomy were performed after percutaneous transhepatic portal vein embolization. A histopathological examination of the liver tumor revealed a gastrinoma. The patient’s serum gastrin concentration on postoperative day 1 decreased to 65 pg/mL. Conclusion We report a surgical case of primary hepatic gastrinoma correctly diagnosed preoperatively. The patient underwent extended right hepatic lobectomy, resulting in a histological definitive diagnosis of primary hepatic gastrinoma.

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The Effect of Intravenous Theophylline Ethylenediamine on Serum Gastrin Concentration in Control Subjects and Patients with Duodenal Ulcers and Zollinger-Ellison Syndrome

Digestion ◽

10.1159/000197935 ◽

1976 ◽

Vol 14 (3) ◽

pp. 227-231 ◽

Cited By ~ 4

Author(s):

G. Feurle ◽

R. Arnold ◽

V. Helmstädter ◽

W. Creutzfeldt

Keyword(s):

Serum Gastrin ◽

Duodenal Ulcers ◽

Control Subjects ◽

Zollinger Ellison Syndrome ◽

Serum Gastrin Concentration

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Effects of Fm100, a fraction of licorice root, on serum gastrin concentration in rats and dogs.

The Japanese Journal of Pharmacology ◽

10.1254/jjp.32.23 ◽

1982 ◽

Vol 32 (1) ◽

pp. 23-27 ◽

Cited By ~ 5

Author(s):

Yasuo ISHII ◽

Yuichi FUJII

Keyword(s):

Serum Gastrin ◽

Licorice Root ◽

Serum Gastrin Concentration

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Scanning electron microscopy of the duodenal mucosa of chickens infected with Eimeria acervulina

Parasitology ◽

10.1017/s0031182000046679 ◽

1975 ◽

Vol 71 (2) ◽

pp. 229-237 ◽

Cited By ~ 16

Author(s):

E. Michael ◽

R. D. Hodges

Keyword(s):

Post Infection ◽

Alimentary Tract ◽

Villous Atrophy ◽

Duodenal Mucosa ◽

Morphological Pattern ◽

Eimeria Acervulina ◽

Intracellular Parasites ◽

Physical Presence ◽

Mucosal Changes ◽

Scanning Electron

The morphology of the duodenal mucosal surface of chickens infected with Eimeria acervulina has been studied on days 5, 6, 8 and 11 post-infection and compared with that of the normal duodenal mucosa using the scanning electron microscope. The normal duodenum possessed tall, spatulate villi with horizontally-arranged surface clefts upon which a regular pattern of hexagonal absorptive cells and goblet cell mouths was superimposed.A maximum degree of villous atrophy was shown on day 5 post-infection, the villi being thickened and flattened with frequent adhesions and fusions between them. The general effects of the disease together with the physical presence of intracellular parasites caused considerable changes in size and shape of the cell apices. By day 8 the mucosa was clearly recovering, with a normal pattern of somewhat thickened and truncated villi beginning to re-appear and by day 11 post-infection the mucosa had regained an outwardly normal morphological pattern. The mucosal changes are discussed in relation to similar changes which occur in diseases of the alimentary tract of other animals, including man.

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The Effect of Renal Transplantation on Basal Serum Gastrin Concentration

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1980.tb09681.x ◽

2009 ◽

Vol 207 (1-6) ◽

pp. 85-87 ◽

Cited By ~ 4

Author(s):

H. E. Nielsen ◽

C. K. Christensen ◽

M. Brandsborg ◽

O. Brandsborg

Keyword(s):

Renal Transplantation ◽

Serum Gastrin ◽

Basal Serum ◽

Serum Gastrin Concentration

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Diffuse annular fusiform adenocarcinoma in a dog

Journal of the American Animal Hospital Association ◽

10.5326/15473317-36-2-169 ◽

2000 ◽

Vol 36 (2) ◽

pp. 169-173 ◽

Cited By ~ 10

Author(s):

MR Prater ◽

B Flatland ◽

SJ Newman ◽

DP Sponenberg ◽

J Chao

Keyword(s):

Large Bowel ◽

Unusual Case ◽

Clinical Signs ◽

Postmortem Examination ◽

Watery Diarrhea ◽

Colonic Adenocarcinoma ◽

German Shepherd ◽

Regional Lymph Nodes ◽

German Shepherd Dog ◽

Neoplastic Lesion

Canine colonic intestinal adenocarcinoma typically presents as rectal polypoid or annular stenotic masses causing clinical signs consistent with large bowel disease. This report discusses an unusual case of intestinal adenocarcinoma in an 11-year-old, neutered male German shepherd dog presented for evaluation of anorexia, profuse watery diarrhea, and weight loss. In this dog, colonic adenocarcinoma diffusely infiltrated the entire large bowel and caused an annular fusiform lesion, as confirmed by endoscopic biopsies and postmortem examination. Other unique features included a paucity of desmoplasia associated with the neoplastic lesion and widespread metastasis to regional lymph nodes, lung, and prostate.

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