licorice root
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2022 ◽  
pp. 35-38
Author(s):  
А.М. ОМАРИ ◽  
Т.А. АРЫСТАНОВА

Работа посвящена разработке методики количественного определения глицирризина и аскорбиновой кислоты при их совместном присутствии в комбинированном лекарственном препарате в виде саше методом УФ-спектрофотометрии. This paper represents a developed technique for the quantitative determination of a new medicinal composition based on dry licorice extract and ascorbic acid for the prevention and treatment of immunode ciency in viral infections by UV spectrophotometry


2022 ◽  
pp. 21-28
Author(s):  
А.М. ОМАРИ ◽  
Т.А. АРЫСТАНОВА

В статье описано современное состояние распространения, переработки и использования солодки в Казахстане. Представлены литературные данные использования компонентов корня солодки в создании лекарственных средств для профилактики и лечения иммунодефицитного состояния при вирусных инфекциях. Обобщены литературные данные о комбинированных препаратах, содержащих экстракт корня солодки, глицирризиновую кислоту. The article describes the current state of distribution, processing and use of licorice in Kazakhstan. The literature data on the use of licorice root components in the creation of medicines for the prevention and treatment of immunodeficiency in viral infections are presented. The literature data on combined preparations containing licorice root extract and glycyrrhizic acid are summarized.


2022 ◽  
Author(s):  
Zaid Abdul Khalik ◽  
Zeyad Saleh ◽  
Mazin Ali

Abstract In this research paper, a method built on UV/VIS spectrofluorophotometer and spectrophotometer by finding the fluorescence of glycyrrhizic acid in licorice root. Glycyrrhizic acid is an imperative active component present in licorice (Glycyrrhiza uralensis Fisch). Solvent effect had been studied in different solvents like deionized water and methanol. The differences between them were explored by the glycyrrhizic acid absorption and emission spectra. Under work conditions, i.e. 100% methanol solvent, a liquid ratio concentration 10−2 to 10−5 g /mL and second solvent with same conditions 100% deionized water in the same concentrations ,was done. The effect of the solvent was significant by change the value for λmax. The result was validated for parameters confines for Ex (λ Excitation) in different solvents. The results of absorption spectra obey Beer-Lambert's law. Because of the same property of these solvents (protic), the absence of a significant difference in the absorption spectra are shown. From florescence spectra, the spectrum at concentration 10−4 is the best for both solvents..


2022 ◽  
Vol 2 (1) ◽  
pp. 1-15
Author(s):  
Mônica Helena Monteiro do Nascimento ◽  
Daniele Ribeiro de Araújo

Glycyrrhizic acid (GA) is the main active component of the licorice root, which has been known in traditional medicine since the ancient times. It is a molecule composed of a hydrophilic part, two glucuronic acid molecules, and a hydrophobic part, glycyrrhetinic acid. GA, when subjected to acid hydrolysis, releases 18β- and 18α-glycyrrhetinic acids. Glycyrrhetinic acid is most responsible for the pharmacological activities of licorice. GA has been reported to have multiple therapeutic properties: anti-viral, anti-inflammatory, antitumor, antimicrobial and hepatoprotective. Different approaches have revealed similar anti-inflammatory mechanisms of action of GA, such as the inhibition of translocation of nuclear factor-κB (NF-κB) and suppression of Tumour Necrosis Factor alpha (TNF-α) and interleukins. In this sense, several in vitro and in vivo studies have described the use of GA in the prevention and treatment of several complications, especially microbial/viral infection, and as a novel chemo-preventive agent for liver injury. Recent studies postulated that GA nanoparticles (GANPs) can be a promising strategy for the treatment of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infections. This mini-review summarizes the pharmacological activities of GA and its beneficial effects against various health problems and provides perspectives on the development of versatile nanoplatforms to overcome some limiting physicochemical properties and for enhancing the therapeutic benefits of GA.


Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7682
Author(s):  
Serena Gabrielli ◽  
Genny Pastore ◽  
Francesca Stella ◽  
Enrico Marcantoni ◽  
Fabrizio Sarasini ◽  
...  

A poly(urethane-acrylate) polymer (PUA) was synthesized, and a sufficiently high molecular weight starting from urethane-acrylate oligomer (UAO) was obtained. PUA was then loaded with two types of powdered ligno-cellulosic waste, namely from licorice root and palm leaf, in amounts of 1, 5 and 10%, and the obtained composites were chemically and mechanically characterized. FTIR analysis of final PUA synthesized used for the composite production confirmed the new bonds formed during the polymerization process. The degradation temperatures of the two types of waste used were in line with what observed in most common natural fibers with an onset at 270 °C for licorice waste, and at 290 °C for palm leaf one. The former was more abundant in cellulose (44% vs. 12% lignin), whilst the latter was richer in lignin (30% vs. 26% cellulose). In the composites, only a limited reduction of degradation temperature was observed for palm leaf waste addition and some dispersion issues are observed for licorice root, leading to fluctuating results. Tensile performance of the composites indicates some reduction with respect to the pure polymer in terms of tensile strength, though stabilizing between data with 5 and 10% filler. In contrast, Shore A hardness of both composites slightly increases with higher filler content, while in stiffness-driven applications licorice-based composites showed potential due to an increase up to 50% compared to neat PUA. In general terms, the fracture surfaces tend to become rougher with filler introduction, which indicates the need for optimizing interfacial adhesion.


Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2751
Author(s):  
Shadma Wahab ◽  
Sivakumar Annadurai ◽  
Shahabe Saquib Abullais ◽  
Gotam Das ◽  
Wasim Ahmad ◽  
...  

There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from the Former Han era. There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency. On the other hand, traditional medicines are getting the attraction to treat many diseases. Therefore, it is vital to screen the medicinal plants to find the potential of new compounds to treat chronic diseases such as respiratory, cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, and the toxicology of licorice, which will serve as a resource for future clinical and fundamental studies. An attempt has been made to establish the pharmacological effect of licorice in different diseases. In addition, the focus of this review article is on the molecular mechanism of licorice extracts and their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, and glabridin) pharmacologic activities. Licorice could be a natural alternative for current therapy to exterminate new emerging disorders with mild side effects. This review will provide systematic insights into this ancient drug for further development and clinical use.


2021 ◽  
Vol 13 (22) ◽  
pp. 12849
Author(s):  
Vasile Staicu ◽  
Cristina Luntraru ◽  
Ioan Calinescu ◽  
Ciprian Gabriel Chisega-Negrila ◽  
Mircea Vinatoru ◽  
...  

In this study, we present a strategy for valorizing lignocellulosic wastes (licorice root and willow bark) that result from industrial extraction of active principles using water as green solvent and aqueous NaOH solution. The wastes were submitted to severe ultrasound (US) and microwave (MW) treatments. The aim of these treatments was to extract the remaining active principles (using water as a solvent) or to prepare them for cellulose enzymatic hydrolysis to hexoses (performed in an NaOH aqueous solution). The content of glycyrrhizic acid and salicin derivatives in licorice root and willow bark wastes, respectively, were determined. The best results for licorice root were achieved by applying the US treatment for 5 min at 25 °C (26.6 mg glycyrrhizic acid/gDM); while, for willow bark, the best results were achieved by applying the MW treatment for 30 min at 120 °C (19.48 mg salicin/gDM). A degradation study of the targeted compounds was also performed and showed good stability of glycyrrhizic acid and salicin derivatives under US and MW treatments. The soluble lignin concentration prior to enzymatic hydrolysis, as well as the saccharide concentration of the hydrolyzed solution, were determined. As compared with the MW treatment, the US treatment resulted in saccharides concentrations that were 5% and 160% higher for licorice root and willow bark, respectively.


2021 ◽  
Vol 923 (1) ◽  
pp. 012004
Author(s):  
Suzan Ali Hussein ◽  
Mahmood Fadhil Al-Doori

Abstract This study was conducted inside the plastic house of the Agricultural Research and Experiment Station of the Agriculture College - University of Kirkuk/Iraq, during the growing season 2020/2021. To study the effect of spraying the growth regulator of benzyl adenine in three concentrations (0, 30, 60) mg.L−1 and licorice root extract in three concentrations (0, 3000, 6000) mg.L−1 on some growth characteristics and chemical content of strawberry plants of Rubygem type. The obtained results were summarized that spraying with a concentration of 60 mg.L−1 of the growth regulator benzyl adenine BA led to a significant superiority in most growth characteristics and chemical content of strawberry plants (leaf area, leaves number, leaves area, dry matter in plant, leaf content of chlorophyll and nitrogen total) where reached (95.81 cm2, 15.78 leaf. plant−1, 1513.93 cm2, 38.68 %, 28.66 %, 3.24 %) respectively. While spraying with concentrations (30 and 60 mg.L−1)of benzyl adenine was significantly superior to the control treatment in the phosphorous and carbohydrates content of leaves. Spraying with a concentration of 6000 mg.L−1 of licorice extract significantly increased in most of the study traits (dry matter in plant, leaf content of chlorophyll, nitrogen, phosphorous and carbohydrates total) where reached (39.06 %, 25.69 mg.g−1, 3.09 %, 0.334 %, 3.38 %) respectively. Spraying with a concentration of 3000 mg.L−1 of licorice was significantly superior in the characteristics of leaf area and Leaves area, which reached (85.08, 1303.18) cm2 respectively.


2021 ◽  
pp. 204-211
Author(s):  
N. I. Lapidus

Cough is one of the auxiliary mechanisms for cleaning the airways from mucus, foreign particles, microorganisms. The physiological cough reflex allows the mechanism of airway cleansing, provided that mucociliary clearance works sufficiently. However, sometimes the cough loses its protective function, becomes persistent, and impairs the quality of life of the patient. In this regard, in the treatment of cough, attention is paid to both secretomotor and secretolytic therapy. Medicinal plants are among the drugs with such properties. Numerous group of drugs containing herbal components has a reflex action, which allows coping most effectively with cough in the initial stages of diseases accompanied by respiratory symptoms. The most common among them and widely used are plantain leaf, coltsfoot leaf, thermopsis herb, ipecacuanha root, marshmallow root, licorice root, anise fruit, thyme (thyme) herb extract, ivy leaf extract. A well-known drug, the active ingredient of which is ivy leaf extract. Its mechanism of action consists in increasing the production of surfactant and increasing the number of β2-adrenoreceptors on the surface of alveolar cells of the bronchial tree, to which ivy active substance α-hederin is attached, which has a bronchospasmodic and expectorant action. Numerous clinical studies have proven a high efficacy and safety of the product based on ivy leaf extract, which allows us to recommend it as the drug of choice for symptomatic cough therapy in both children and adults during acute respiratory infections.


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