Preoperative Transdermal Hyoscine for the Prevention of Postoperative Nausea and Vomiting

In a randomised, double-blind study, a transdermal patch containing either hyoscine or placebo was applied post-auricularly in 190 adult patients under 65 years old, seven to twelve hours prior to their undergoing minor orthopaedic or plastic surgery under thiopentone/nitrous oxide/halothane general anaesthesia. In the first 24 hours after surgery 34% of patients vomited. The incidence of nausea (31% vs 54%; P< 0.01) and the number of episodes of vomiting (66 vs 125; P< 0.05) during the first 24 hours were significantly less with hyoscine than with placebo. The hyoscine group required fewer doses of antiemetic than the placebo group (12 vs 27; P < 0.05). Side-effects were mild, the only difference between the two groups being the frequency of dry mouth immediately preoperatively. No differences were seen in the second 24 hours after surgery. We conclude that transdermal hyoscine is moderately effective in reducing the occurrence of postoperative nausea and vomiting following minor surgery.

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Ondansetron 4 mg for the Prevention of Nausea and Vomiting after Minor Laparoscopic Gynaecological Surgery

Anaesthesia and Intensive Care ◽

10.1177/0310057x9402200203 ◽

1994 ◽

Vol 22 (2) ◽

pp. 142-146 ◽

Cited By ~ 26

Author(s):

T. K. L. Suen ◽

T. A. Gin ◽

P. P. Chen ◽

Y. M. Rowbottom ◽

L. A. H. Critchley ◽

...

Keyword(s):

Placebo Group ◽

Laparoscopic Surgery ◽

Postoperative Nausea ◽

Postoperative Nausea And Vomiting ◽

Nausea And Vomiting ◽

Double Blind ◽

Randomised Study ◽

Group 12 ◽

Induction Of Anaesthesia ◽

Numeric Scale

We studied the efficacy and safety of intravenous ondansetron 4 mg for the prevention of postoperative nausea and vomiting after minor gynaecological laparoscopic surgery in Oriental women. This double-blind randomised study compared ondansetron with placebo, given before the induction of anaesthesia. The anaesthetic technique used thiopentone, fentanyl, atracurium, nitrous oxide and isoflurane. Patients were studied for 24 h with nausea assessed using a verbal numeric scale from 0-10 and emetic episodes recorded as they occurred. Results were available for 102 patients in each group. In the first postoperative hour, fewer patients in the ondansetron Group (12%) had emetic episodes compared with the placebo group (33%, P <0.01). Nausea score over the first hour (sum of three readings at 0, 30 and 60 min) was lower in the ondansetron group (median 1.6) compared with the placebo group (3.1, P <0.05). Over the 24 h period, fewer patients in the ondansetron group had emetic episodes (25%) or nausea (43%) compared with patients in the placebo group (56%, P <0.01) and (58%, P <0.05) respectively. No adverse events were seen. Ondansetron 4 mg was more effective than placebo in preventing postoperative nausea and vomiting throughout the 24 h after minor laparoscopic surgery.

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Ondansetron for Prevention of Postoperative Nausea and Vomiting following Minor Oral Surgery: A Double-blind Randomized Study

Anaesthesia and Intensive Care ◽

10.1177/0310057x9402200513 ◽

1994 ◽

Vol 22 (5) ◽

pp. 576-579 ◽

Cited By ~ 16

Author(s):

M. R. C. Rodrigo ◽

R. C. H. Campbell ◽

J. Chow ◽

C. K. A. Tong ◽

E. Hui ◽

...

Keyword(s):

Placebo Group ◽

Postoperative Nausea ◽

Oral Surgery ◽

Postoperative Nausea And Vomiting ◽

Nausea And Vomiting ◽

General Anaesthetic ◽

Double Blind Study ◽

Double Blind ◽

Significant Difference ◽

Minor Oral Surgery

The efficacy and safety of ondansetron in preventing postoperative nausea and vomiting following minor oral surgery was evaluated in a prospective randomized double-blind study. Of a total of seventy-seven patients, randomly 38 had 4 mg of ondansetron and 39 had normal saline as placebo intravenously immediately prior to induction of anaesthesia. A standard general anaesthetic with thiopentone, suxamethonium, fentanyl, nitrous oxide and isoflurane was employed. Postoperatively nausea was assessed verbally and on a visual analog scale at 1, 4 and 24 hours from the time of awakening. Episodes of vomiting were recorded. Eight patients (21.1%) in the ondansetron group compared to 19 (48.7%) in the placebo group had nausea (P < 0.05) and 1 (2.6%) in the ondansetron group compared with 9 (23.1%) in the placebo group vomited (P < 0.05). Patients who vomited twice or more and the number who required a rescue antiemetic were significantly fewer in the ondansetron group (P < 0.05). Cardiovascular parameters were stable and showed no significant difference in the two groups. There were no significant adverse effects that could be directly attributable to ondansetron.

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