Occurrence of Salivary Gland Tumours in Two Patients Treated with Biological Agents

2012 ◽  
Vol 25 (1) ◽  
pp. 297-300 ◽  
Author(s):  
M. Carlesimo ◽  
E. Mart ◽  
M. La Pietra ◽  
D. Orsini ◽  
G. Pranteda ◽  
...  

We report two cases of salivary gland tumors arising in two psoriatic patients treated with an anti-TNF-alpha agent. A clear causal relationship could not be established, but the exceptional onset of a bilateral Warthin's tumor in one of these patients should be emphasized.

Author(s):  
Neha Swarnkar ◽  
Srinivasan Venkataraman ◽  
Prasanna Kumar Saravanam

<p><strong>Background:</strong> Salivary gland tumors are morphologically and histologically diverse group of lesions and their frequency varies in several parts of the world. Better understanding of these tumours will help in assessing the behaviour and outcomes of lesions of this region. The aim of this study was to analyse the charactertistics of different tumours occurring in the salivary gland in a tertiary care centre in South India.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was conducted of salivary gland tumors diagnosed from the year 2015 to 2020. Patient age and gender, tumor site and frequency, histopathological diagnosis were evaluated and analysed.</p><p class="abstract"><strong>Results:</strong> A total of 36 salivary gland tumor cases was identified, 30 (87.3%) of which were classified as benign and 6 (12.7%) as malignant. Most tumors occurred in the parotid gland (81.3%). Pleomorphic adenoma was the most common tumor in 23 patients (63.8%), followed by warthins tumour. The tumors occurred more often in women than men.</p><p><strong>Conclusion: </strong>The results of the present study reinforce prevalence of salivary gland tumours. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors also can occur in these glands and good clinical suspicion is necessary.</p><p class="abstract"> </p>


1993 ◽  
Vol 72 (4) ◽  
pp. 264-273 ◽  
Author(s):  
Alain H. Shikhani ◽  
Lama T. Shikhani ◽  
Francis P. Kuhajda ◽  
Charles K. Allam

The association of Warthin's tumor with another neoplasm of a different histological type in the same salivary gland is extremely rare. The literature includes 42 such cases to date. A case of malignant lymphoma developing within Warthin's tumor and another case of oncocytoma synchronous with Warthin's tumor in the same parotid gland are reported. The relation of Warthin's tumor to other neoplasms is discussed.


1999 ◽  
Vol 43 (6) ◽  
pp. 1052-1058 ◽  
Author(s):  
Tadao K. Kobayashi ◽  
Masami Ueda ◽  
Toshihiro Nishino ◽  
Ryoji Kushima ◽  
Shigemi Nakajima ◽  
...  

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S98-S98
Author(s):  
Fei Chen ◽  
Lopa Modi ◽  
Ronaldo Zamuco ◽  
Melissa Yee-Chang

Abstract Fine-needle aspiration biopsies (FNABs) are a common modality used in the evaluation of salivary gland neoplasms. We present the cytologic and histologic features of a rare case of lymphoepithelioma-like carcinoma (LELC) in a 40-year-old Hispanic male with a 1.0-cm painless well-circumscribed parotid mass that had been present for 8 years. FNAB smears showed cohesive groups of intermediate-sized basaloid cells with vesicular nuclei, occasional pleomorphic nuclei and prominent nucleoli, and spindled morphology. Mature lymphocytes were seen in the background, either adjacent to the atypical epithelial cells or dispersed in the background. This lymphoid background raises considerations of salivary gland neoplasms that can have prominent lymphocytic backgrounds, such as acinic cell carcinoma and, more commonly, Warthin’s tumor or metastasis involving intraparotid lymph node. Surgical resection of the parotid showed syncytial sheets of predominantly undifferentiated cells with spindled to epithelioid morphology and occasional prominent nucleoli and focal areas of squamous differentiation. The background showed dense areas of lymphocytes with germinal center formation. Immunohistochemical (IHC) stains showed positive reactivity for p63, p40, and EBV in situ hybridization (EBV ISH) in the tumor cells and negative reactivity for p16. The findings were supportive of LELC if a metastasis from the nasopharynx was excluded. A subsequent nasopharyngeal biopsy was benign. Although histologic features of LELC are well established, we identified rare case reports describing the cytomorphology in the literature. Cytopathologists should be aware of this lesion as another salivary gland neoplasm that can show lymphocytes admixed with the tumor cells and a distinct lymphoid background. The basaloid appearance and cytologic atypia should distinguish it from acinic cell carcinoma and Warthin’s tumor. However, metastatic lesions should also be considered with a distinct lymphoid background and need to be clinically excluded before establishing the diagnosis of LELC.


Author(s):  
Akshay Akulwar ◽  
Akshay Bavikatte

Introduction: Salivary gland tumours are rare tumours and majority of these are benign and about 20% are malignant. The incidence of salivary gland cancers ranges from 0.5 to 2 per 100,000 in different parts of the world. Salivary gland swellings in the parotid or submandibular glands usually present as an enlarging mass and may be associated with neurological symptoms like facial nerve paralysis or pain. Minor salivary gland tumours present as a submucosal intraoral mass which subsequently ulcerates. Acute inflammatory conditions generally can be diagnosed by history and physical examination alone, whereas chronic inflammatory diseases and granulomatous disorders require supplemental diagnostic information including lab tests, imaging studies and biopsy. FNAC of salivary gland tumours is advantageous to both the patient and the clinician because of its immediate results, accuracy, lack of complications and economy. Appropriate therapeutic management may be planned earlier, whether it is local excision for a benign neoplasm, radical surgery for a malignant one or any other alternate treatment. Material and Methods: All patients admitted to surgical wards due to obstructions of the salivary duct and neoplasia were included in the study. Demographic data from all the patients were collected, also they were evaluated for clinical examination, routine laboratory investigations and specific investigations. After evaluation of the swellings by clinical examination and by specific investigations, a surgical plan was formulated. The final decision was taken by the operative surgeon. Results: 40 cases of salivary gland swellings were admitted during study period. Age of the patients varied from 9 years to 80 years. 62.5% (25 cases) were found in the parotid gland, 30% cases (12) in submandibular gland and 7.5% cases (3) in the sublingual gland. Surgery was the treatment for all cases of tumors. Superficial parotidectomy was done in all the 21 cases of parotid tumour (56.41%) without deep lobe involvement and total parotidectomy was done in 3 cases (7.6%) with deep lobe involvement. In all the cases of submandibular gland lesions, excision of submandibular gland was done. Excision of the sublingual gland was done in 3 cases of ranula. One case of adenoid cystic cacinoma was referred to higher center because   of the advanced malignancy. Conclusion: Salivary gland tumors occur more commonly in the parotid gland, most often benign, pleomorphic adenoma constitute majority of all neoplasm. Surgery is the main modality of treatment in salivary gland sialolithiasis. Most commonly done surgery is excision of submandibular salivary gland & superficial parotidectomy and also for salivary gland tumors. Awareness and early referral is necessary, as prognosis is good if treated early. Keywords: SALIVARY GLAND, TUMOUR, NEOPLASM, SURGERY


Sign in / Sign up

Export Citation Format

Share Document