Relative Inhalation Toxicity in Rats of Pyrolysis Products from Polymeric Materials

ABSTRACTThe controlled hydrolysis of Al(O-sec-Bu)3 and Y(O-iso-Pr)3 or the reaction of Y(OOCCH)3 with partially hydrolyzed Al(O-sec-Bu)3 [AlO0.75(O-sec-Bu)1.5] resulted in the formation of soluble polymeric materials. Pyrolysis of these materials under a flow of oxygen led to the formation of yttrium aluminum garnet (YAG) at 650-1500°C. YAG was the only crystalline phase observed during pyrolysis, and the Al/Y ratio of the pyrolysis products and the starting material was identical. However, infrared spectroscopy indicated that carbonate groups and entrained CO2 existed in the products at temperatures up to 1250°C. The pyrolysis chemistry of the precursors and the microstructure of the products were studied by FT-IR, TGA, XRD, SEM and elemental analyses.

Download Full-text

PYROLYSIS PRODUCTS OF POLYTETRAFLUOROETHYLENE AND POLYFLUOROETHYLENEPROPYLENE WITH REFERENCE TO INHALATION TOXICITY

The Annals of Occupational Hygiene ◽

10.1093/annhyg/20.3.247 ◽

1977 ◽

Cited By ~ 15

Keyword(s):

Inhalation Toxicity ◽

Pyrolysis Products

Download Full-text

Toxic pulmonary edema due to inhalation of pyrolyzed polytetrafluoroethylene products in lab animals

Medico-Biological and Socio-Psychological Problems of Safety in Emergency Situations ◽

10.25016/2541-7487-2018-0-3-80-85 ◽

2018 ◽

pp. 80-85

Author(s):

P. G. Tolkach ◽

V. A. Basharin ◽

S. V. Chepur

Keyword(s):

Thermal Decomposition ◽

Pulmonary Edema ◽

Polymeric Materials ◽

Relative Content ◽

Mass Spectrometric ◽

Laboratory Animals ◽

Pyrolysis Products ◽

Emergency Situations ◽

Pathogenetic Therapy ◽

Alveolar Edema

Relevance.Thermal decomposition of various polymeric materials occur in emergency situations associated with fires, with pulmonotoxicants releasing in the environment. During pyrolysis of polytetrafluoroethylene (Teflon), a highly toxic perfluoroisobutylene is produced.Intention.To create an experimental animal model of toxic pulmonary edema due to products of thermal decomposition of polytetrafluoroethylene.Methodology.Polytetrafluoroethylene underwent pyrolysys at 440–750 0С during 6 minutes. Toxic pulmonary edema was modeled on rats via inhalation of pyrolysis products of polytetrafluoroethylene. An amount of polytetrafluoroethylene burned under these conditions with resulting death of 50 % of rats during 1 day was (2.68 ± 0.60) g. The toxic pulmonary edema diagnosis was confirmed histologically and by lung/body ratio.Results.In the pyrolysis products of polytetrafluoroethylene, highly toxic perfluoroisobutylene was found via gas chromatography with mass spectrometric detection, with relative content of 85.9 %. Such an exposure during 15 min increased (p = 0.01) lung/body ratio in laboratory animals in 3 hours. The toxic pulmonary edema diagnosis was confirmed histologically (signs of alveolar edema). Animals started to die 7 hours after the pyrolysis products inhalation.Conclusion.In the study on rats, toxic pulmonary edema was modeled via inhalation of pyrolysis products of polytetrafluoroethylene. This model can be used for searching etiotropic and pathogenetic therapy for poisoning with pulmonotoxicants.

Download Full-text