Risk of Second Seizure in Pediatric Patients With Idiopathic Autism

2017 ◽  
Vol 32 (10) ◽  
pp. 876-879 ◽  
Author(s):  
Asad A. Qadir ◽  
Emily Obringer ◽  
Joseph Hageman ◽  
Charles Marcuccilli
Keyword(s):  
Autism Spectrum Disorder ◽  
High Risk ◽  
Retrospective Review ◽  
Pediatric Patients ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Seizure Recurrence ◽  
The University ◽  
Short Time

Purpose: Epilepsy is a comorbidity of idiopathic autism spectrum disorder. The aim was to characterize the risk and time of second seizure in children with idiopathic autism spectrum disorder. Methods: A retrospective review was performed at the University of Chicago and NorthShore University HealthSystem. Patients with idiopathic autism spectrum disorder, ≥1 seizure, and age 2 to 23 years were included. Results: 153 patients were included; 141 (92%) had a second seizure. The average age at first seizure was 7.14 years (median: 5.08 years) and 8.12 years (median: 7.3 years) at second seizure. Average time between first and second seizure was 7.68 months. Discussion: A high risk of seizure recurrence was found in this population. There was a short time to second seizure, with most having a recurrence within 1 year. These findings may be used to guide therapy in children with autism spectrum disorder and epilepsy.

scholarly journals Resistance to temptation in toddlers at genetic risk for autism spectrum disorder

Autism ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 1018-1027
Author(s):  
Susan B Campbell ◽  
Jessie B Northrup ◽  
Amy B Tavares
Keyword(s):  
Autism Spectrum Disorder ◽  
High Risk ◽  
Young Children ◽  
Self Regulation ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Low Risk ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
High Risk Children

Children with autism spectrum disorder often demonstrate difficulties with self-regulation, although studies of this construct in young children with autism spectrum disorder are limited. In this study, developmental changes were examined using a measure of self-regulation appropriate for young children, resistance to temptation. At 22, 28, and 34 months, toddlers with an older sibling with autism spectrum disorder (high risk) and toddlers with typically developing older siblings (low risk) were presented with an appealing toy and instructed not to touch it. Observers coded whether or not children touched the toy and the strategies they used to resist touching it. At 36 months, children were assessed for autism spectrum disorder, yielding three groups: high risk children with autism spectrum disorder, high risk children without autism spectrum disorder, and low risk children. At 22 months, most children, regardless of group, touched the forbidden toy; at 28 and 34 months, many high risk children without autism spectrum disorder and low risk children resisted the temptation to touch the toy, whereas most of the children with autism spectrum disorder did not. Differences in delay strategies were also evident. Some, but not all group differences, were accounted for by differences in language ability. Results highlight one early index of impulse control that differentiates children with emerging autism spectrum disorder from age-mates prior to the third birthday.

Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort

2012 ◽  
Vol 42 (12) ◽  
pp. 2585-2596 ◽  
Author(s):  
Lonnie Zwaigenbaum ◽  
Susan E. Bryson ◽  
Peter Szatmari ◽  
Jessica Brian ◽  
Isabel M. Smith ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Sex Differences ◽  
High Risk ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
High Risk Infant

scholarly journals IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder

2020 ◽  
Vol 117 (28) ◽  
pp. 16475-16480 ◽  
Author(s):  
Irene Tsilioni ◽  
Harry Pantazopoulos ◽  
Pio Conti ◽  
Susan E. Leeman ◽  
Theoharis C. Theoharides
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Interactions ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
University Of Maryland ◽  
Human Microglia ◽  
Adult Human ◽  
Children With Asd ◽  
The University

Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory molecules IL-1β and CXCL8. This process is inhibited by the cytokine IL-37. Another cytokine, IL-38, has been reported to have antiinflammatory actions. In this report, we show that pretreatment of cultured adult human microglia with recombinant IL-38 (aa3-152, 1–100 ng/mL) inhibits (P< 0.0001) NT-stimulated (10 nM) secretion of IL-1β (at 1 ng/mL) and CXCL8 (at 100 ng/mL). In fact, IL-38 (aa3-152, 1 ng/mL) is more potent than IL-37 (100 ng/mL). Here, we report that pretreatment with IL-38 (100 ng/mL) of embryonic microglia (HMC3), in which secretion of IL-1β was undetectable, inhibits secretion of CXCL8 (P= 0.004). Gene expression of IL-38 and its receptor IL-36R are decreased (P= 0.001 andP= 0.04, respectively) in amygdala from patients with ASD (n= 8) compared to non-ASD controls (n= 8), obtained from the University of Maryland NeuroBioBank. IL-38 is increased (P= 0.03) in the serum of children with ASD. These findings indicate an important role for IL-38 in the inhibition of activation of human microglia, thus supporting its development as a treatment approach for ASD.

scholarly journals Differential attention to faces in infant siblings of children with autism spectrum disorder and associations with later social and language ability

2016 ◽  
Vol 42 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Jennifer B. Wagner ◽  
Rhiannon J. Luyster ◽  
Hana Moustapha ◽  
Helen Tager-Flusberg ◽  
Charles Alexander Nelson
Keyword(s):  
Autism Spectrum Disorder ◽  
High Risk ◽  
Positive Association ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Social Attention ◽  
Small Sample ◽  
Spectrum Disorder ◽  
Infant Siblings ◽  
Communicative Behavior

A growing body of literature has begun to explore social attention in infant siblings of children with autism spectrum disorder (ASD) with hopes of identifying early differences that are associated with later ASD or other aspects of development. The present study used eye-tracking to familiar (mother) and unfamiliar (stranger) faces in two groups of 6-month-old infants: infants with no family history of ASD (low-risk controls; LRC), and infants at high risk for ASD (HRA), by virtue of having an older sibling with ASD. HRA infants were further characterized based on autism classification at 24 months or older as HRA- (HRA without an ASD outcome) or HRA+ (HRA with an ASD outcome). For time scanning faces overall, HRA+ and LRC showed similar patterns of attention, and this was significantly greater than in HRA-. When examining duration of time spent on eyes and mouth, all infants spent more time on eyes than mouth, but HRA+ showed the greatest amount of time looking at these regions, followed by LRC, then HRA-. LRC showed a positive association between 6-month attention to eyes and 18-month social-communicative behavior, while HRA- showed a negative association between attention to eyes at 6 months and expressive language at 18 months (all correlations controlled for non-verbal IQ; HRA- correlations held with and without the inclusion of the small sample of HRA+). Differences found in face scanning at 6 months, as well as associations with social communication at 18 months, point to potential variation in the developmental significance of early social attention in children at low and high risk for ASD.

Investigating variables which predict the presence and severity of aggression and self-injurious behavior in children with autism spectrum disorder

2020 ◽  
Author(s):  
◽  
Deija McLean
Keyword(s):  
Autism Spectrum Disorder ◽  
Aggressive Behavior ◽  
Social Withdrawal ◽  
Challenging Behaviors ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
University Of Missouri ◽  
Negative Impacts ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Literature indicates that individuals diagnosed with autism spectrum disorder (ASD) are at-risk for developing challenging behaviors (Holden and Gitlesen, 2006; McClintock et al., 2003). Challenging behaviors such as aggression and self-injurious behavior (SIB) warrant additional attention due to the negative impacts associated with the presence of these behaviors. The purpose of the current study was to investigate variables which predict the presence and severity of aggression and self-injurious behavior (SIB) in a large sample (n = 2100) of children with autism spectrum disorder (ASD). According to results of regression analyses, the presence of lethargy/social withdrawal behavior, irritability, and hyperactivity/noncompliance were predictive of aggressive behavior in this sample. Irritability and hyperactivity/noncompliance also predicted severity of exhibited aggressive behavior. Older age and the presence of inappropriate speech, irritability and aggression were predictive of SIB in this population. Irritability also predicted severity of exhibited SIB. Implications for research and practice are discussed.

Instruction Using Augmentative and Alternative Communication Supports: Description of Current Practices by Speech-Language Pathologists Who Work With Children With Autism Spectrum Disorder

2020 ◽  
Vol 29 (2) ◽  
pp. 586-596 ◽  
Author(s):  
Kaitlyn A. Clarke ◽  
Diane L. Williams
Keyword(s):  
Autism Spectrum Disorder ◽  
Augmentative And Alternative Communication ◽  
Communication Systems ◽  
Diagnostic Category ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Alternative Communication ◽  
Speech Language Pathologists ◽  
Processing Differences

Purpose The aim of this research study was to examine common practices of speech-language pathologists (SLPs) who work with children with autism spectrum disorder (ASD) with respect to whether or not SLPs consider processing differences in ASD or the effects of input during their instruction. Method Following a qualitative research method, how SLPs instruct and present augmentative and alternative communication systems to individuals with ASD, their rationale for method selection, and their perception of the efficacy of selected interventions were probed. Semistructured interviews were conducted as part of an in-depth case report with content analysis. Results Based on completed interviews, 4 primary themes were identified: (a) instructional method , (b) input provided , (c) decision-making process , and (d) perceived efficacy of treatment . Additionally, one secondary theme, training and education received , was identified . Conclusions Clinicians reported making decisions based on the needs of the child; however, they also reported making decisions based on the diagnostic category that characterized the child (i.e., ASD). The use of modeling when teaching augmentative and alternative communication to individuals with ASD emerged as a theme, but variations in the method of modeling were noted. SLPs did not report regularly considering processing differences in ASD, nor did they consider the effects of input during instruction.

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