Association of Neutrophil/Lymphocyte Ratio With Intravenous Immunoglobulin Treatment in Children With Guillain-Barré Syndrome

2018 ◽  
Vol 33 (2) ◽  
pp. 164-167 ◽  
Author(s):  
Ezgi Altuntas Hüner ◽  
Alper I. Dai ◽  
Abdullah T. Demiryürek
Keyword(s):  
Nervous System ◽  
Intravenous Immunoglobulin ◽  
Medical Records ◽  
University Hospital ◽  
Guillain Barre Syndrome ◽  
Neutrophil Lymphocyte Ratio ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Immunoglobulin Treatment ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory polyneuropathy of the peripheral nervous system. The authors aimed to investigate whether the neutrophil/lymphocyte (N/L) and platelet/lymphocyte (P/L) ratios are the parameters that associated with the drug treatment or severity of GBS. Twenty-seven children with GBS were retrospectively analyzed from the medical records of patients who attended to the Pediatric Neurology Department of the Gaziantep University Hospital. Biochemical and hematologic parameters were measured. Leukocytes, neutrophils counts and N/L ratio were significantly higher before the intravenous immunoglobulin treatment ( P < .001). However, there were no marked differences in platelet count and P/L ratio. In addition, marked correlation was observed between the N/L ratio after treatment and duration of weakness. The results of the study showed that N/L ratio is significantly higher in GBS patients, and reduces following with intravenous immunoglobulin treatment.

Intravenous Immunoglobulin Treatment in Children with Guillain-Barre Syndrome

1995 ◽  
Vol 27 (3) ◽  
pp. 241-243 ◽  
Author(s):  
Nuran Gürses ◽  
Serap Uysal ◽  
Feyzullah Çetinkaya ◽  
Ismail Işek ◽  
Ayhan Gazi Kalayci
Keyword(s):  
Intravenous Immunoglobulin ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Immunoglobulin Treatment ◽  
Guillain Barré

scholarly journals Rescue treatment in patients with poorly responsive Guillain–Barre syndrome

2019 ◽  
Vol 7 ◽  
pp. 205031211984019 ◽  
Author(s):  
Ayman Mahmoud Alboudi ◽  
Pournamy Sarathchandran ◽  
Samar Sameer Geblawi ◽  
Deeb Maxwell Kayed ◽  
Jihad Inshasi ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Guillain Barre Syndrome ◽  
Line Treatment ◽  
Second Line ◽  
Rescue Treatment ◽  
Significant Difference ◽  
Guillain Barré Syndrome ◽  
Immunoglobulin Treatment ◽  
Guillain Barré

Objectives: To evaluate the effectiveness of rescue treatment (intravenous immunoglobulin or plasma exchange) in patients with Guillain–Barre syndrome who did not respond or deteriorated after the initial management with intravenous immunoglobulin. Methods: We performed a retrospective review of the medical records of patients who responded poorly or did not respond to intravenous immunoglobulin treatment. The disability parameters of those who received second-line treatment with intravenous immunoglobulin or plasma exchange (20 patients) were compared with those who did not receive second-line treatment (19 patients). Results: There was a statistically significant improvement in disability scores at 1 month in the patients who received the rescue treatment (p = 0.033). However, there was no significant difference in the disability scores at 3 and 6 months, or in length of intensive care unit stay. Conclusion: Our study showed that a second course of treatment to carefully selected patients may be beneficial

scholarly journals Analysis of the albumin level, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in Guillain-Barré syndrome

2016 ◽  
Vol 74 (9) ◽  
pp. 718-722 ◽  
Author(s):  
Hasan Huseyin Ozdemir
Keyword(s):  
Axonal Neuropathy ◽  
Albumin Level ◽  
Post Treatment ◽  
University Hospital ◽  
Guillain Barre Syndrome ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

ABSTRACT The purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes’ scores. Post-treatment albumin levels in GBS were significantly reduced, and albumin level was negatively correlated with the Hughes scores. Elevated pretreatment NLRs and PLRs were significantly associated with AIDP. There were no correlations between the Hughes scores, NLR, and PLR. The results point to a negative correlation between albumin levels and GBS disability and suggest that the NLR and PLR may be promising blood biomarkers of AIDP.

Reversible Splenial Lesion Syndrome After Intravenous Immunoglobulin Treatment for Guillain-Barre Syndrome

2017 ◽  
Vol 40 (5) ◽  
pp. 224-225 ◽  
Author(s):  
Elif Uygur Kucukseymen ◽  
Burcu Yuksel ◽  
Fatma Genc ◽  
Eylem Ozaydin Goksu ◽  
Sevim Yildiz ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Guillain Barre Syndrome ◽  
Splenial Lesion ◽  
Guillain Barré Syndrome ◽  
Immunoglobulin Treatment ◽  
Guillain Barré ◽  
Reversible Splenial Lesion Syndrome
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