Commissurotomies in Children

Although corpus callosotomy has been used since 1940 to treat severe, medically intractable seizure disorders, controversy remains as to when, or even if, the surgery should be performed. Unlike other types of surgical therapy of epilepsy where the epileptic focus is identified and removed, corpus callosotomy is used to interrupt the propagation of epileptic discharges. The procedure is primarily used in patients with secondarily generalized seizures in whom focal resections are not possible. Long-term follow-up studies of post-callosotomy patients are few and flawed by lack of accurate seizure counts and quality-of-life measures. Although it remains difficult to predict those patients who will benefit from the surgery, it appears that patients with "drop" attacks benefit the most from the procedure. (J Child Neurol 1994;9(Suppl):2S50-2S60).

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Clinical update: Bone Marrow Transplantation vs. High-Dose Cytorabine-Based Consolidation Chemotherapy for Acute Myelogenous Leukemia: A Long-Term Follow-Up Study of Quality-of-Life Measures of Survivors. Wellisch, D.K., Centreno, J., Guzman, J., Belin, T. and Schiller, G.J. (1996)Psychosomatics37, 144–154.

Psycho-Oncology ◽

10.1002/(sici)1099-1611(199703)6:1<75::aid-pon1259>3.0.co;2-a ◽

1997 ◽

Vol 6 (1) ◽

pp. 75-75

Author(s):

William Breitbart ◽

Ann Cull ◽

Donna Greenberg

Keyword(s):

Myelogenous Leukemia ◽

High Dose ◽

Consolidation Chemotherapy ◽

Follow Up Study ◽

Quality Of Life Measures ◽

Long Term Follow Up ◽

Acute Myelogenous

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Long-term Follow-up of Patients With Lyme Disease: Longitudinal Analysis of Clinical and Quality-of-life Measures

Clinical Infectious Diseases ◽

10.1093/cid/ciw189 ◽

2016 ◽

Vol 62 (12) ◽

pp. 1546-1551 ◽

Cited By ~ 25

Author(s):

Aprielle B. Wills ◽

Alicen B. Spaulding ◽

Jennifer Adjemian ◽

D. Rebecca Prevots ◽

Siu-Ping Turk ◽

...

Keyword(s):

Quality Of Life ◽

Lyme Disease ◽

Longitudinal Analysis ◽

Quality Of Life Measures ◽

Long Term Follow Up

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Long-term seizure outcome after corpus callosotomy: a retrospective analysis of 95 patients

Journal of Neurosurgery ◽

10.3171/2008.3.17570 ◽

2009 ◽

Vol 110 (2) ◽

pp. 332-342 ◽

Cited By ~ 77

Author(s):

Taner Tanriverdi ◽

André Olivier ◽

Nicole Poulin ◽

Frederick Andermann ◽

François Dubeau

Keyword(s):

Seizure Type ◽

Seizure Outcome ◽

Corpus Callosotomy ◽

Drop Attacks ◽

Her Family ◽

Long Term Follow Up ◽

Clonic Seizures ◽

Expected Benefits

Object The authors report long-term follow-up seizure outcome in patients who underwent corpus callosotomy during the period 1981–2001 at the Montreal Neurological Institute. Methods The records of 95 patients with a minimum follow-up of 5 years (mean 17.2 years) were retrospectively evaluated with respect to seizure, medication outcomes, and prognostic factors on seizure outcome. Results All patients had more than one type of seizure, most frequently drop attacks and generalized tonicclonic seizures. The most disabling seizure type was drop attacks, followed by generalized tonic-clonic seizures. Improvement was noted in several seizure types and was most likely for generalized tonic-clonic seizures (77.3%) and drop attacks (77.2%). Simple partial, generalized tonic, and myoclonic seizures also benefited from anterior callosotomy. The extent of the callosal section was correlated with favorable seizure outcome. The complications were mild and transient and no death was seen. Conclusions This study confirms that anterior callosotomy is an effective treatment in intractable generalized seizures that are not amenable to focal resection. When considering this procedure, the treating physician must thoroughly assess the expected benefits, limitations, likelihood of residual seizures, and the risks, and explain them to the patient, his or her family, and other caregivers.

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