Novel resorbable glass-ceramic scaffolds for hard tissue engineering: From the parent phosphate glass to its bone-like macroporous derivatives

Apatite-wollastonite bioactive glass-ceramic scaffolds were fabricated from the SiO2-CaO-P2O5 MgO-CaF2 glass system by controlled crystallization between 800 and 1200C of the melted and quenched glass powder. Wood powder with controlled particle size distribution was used to obtain bioactive glass-ceramic scaffolds by burning-out process during crystallization of glass. Bioactive phases of apatite and wollastonite were found in all crystallized samples but the relative amount depended on the crystallization temperature. The bioactivity was studied via simulated body fluid (SBF) solution from 2 to 12 weeks. After soaking for 2 weeks, a porous hydroxyl-carbonate apatite (HCA) layer formed at the SBF-glass ceramic interface and the HCA layer thickness increased at longer soaking periods. This study led to a promising platform for hard tissue engineering.

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Hard Tissue Engineering

Tissue Engineering in Oral and Maxillofacial Surgery ◽

10.1007/978-3-030-24517-7_7 ◽

2019 ◽

pp. 85-96

Author(s):

Riitta Seppänen-Kaijansinkko

Keyword(s):

Tissue Engineering ◽

Hard Tissue ◽

Hard Tissue Engineering

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Scaffolds for Hard Tissue Engineering by Ionotropic Gelation of Alginate?Influence of Selected Preparation Parameters

Journal of the American Ceramic Society ◽

10.1111/j.1551-2916.2007.01598.x ◽

2007 ◽

Vol 90 (6) ◽

pp. 1703-1708 ◽

Cited By ~ 43

Author(s):

R. Dittrich ◽

G. Tomandl ◽

F. Despang ◽

A. Bernhardt ◽

Th. Hanke ◽

...

Keyword(s):

Tissue Engineering ◽

Hard Tissue ◽

Ionotropic Gelation ◽

Hard Tissue Engineering

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Development of a novel biomaterial with an important osteoinductive capacity for hard tissue engineering

Tissue and Cell ◽

10.1016/j.tice.2018.04.004 ◽

2018 ◽

Vol 52 ◽

pp. 101-107 ◽

Cited By ~ 5

Author(s):

Meda-Romana Simu ◽

Emoke Pall ◽

Teodora Radu ◽

Maria Miclaus ◽

Bogdan Culic ◽

...

Keyword(s):

Tissue Engineering ◽

Hard Tissue ◽

Hard Tissue Engineering

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Preparation and performance evaluation of electrospun poly(3-hydroxybutyrate) composite scaffolds as a potential hard tissue engineering application

Journal of Bioactive and Compatible Polymers ◽

10.1177/0883911519875984 ◽

2019 ◽

Vol 34 (4-5) ◽

pp. 386-400 ◽

Cited By ~ 1

Author(s):

Moein Zarei ◽

Nader Tanideh ◽

Shahrokh Zare ◽

Fatemeh Sari Aslani ◽

Omid Koohi-Hosseinabadi ◽

...

Keyword(s):

Tissue Engineering ◽

Carbon Nanotube ◽

Engineering Application ◽

Tissue Engineering Application ◽

Hydroxyapatite Nanoparticles ◽

Hard Tissue ◽

Composite Scaffolds ◽

Tissue Reactions ◽

Hard Tissue Engineering

In the present study, poly(3-hydroxybutyrate)-based composite scaffolds were prepared with multi-walled carbon nanotubes and hydroxyapatite nanoparticles for hard tissue engineering applications by electrospinning. All the prepared scaffolds showed connective porous structure, which were suitable for cell proliferation and migration. The mechanical properties of the poly(3-hydroxybutyrate) scaffold were improved by 0.5% of carbon nanotube addition, whereas the addition of hydroxyapatite nanoparticles up to 10% had an insignificant effect in tensile strength. However, scanning electron microscopy and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results suggested that the mesenchymal stem cells attachment and their metabolic activities on the surface of the poly(3-hydroxybutyrate) scaffolds with hydroxyapatite were enhanced compared to poly(3-hydroxybutyrate) scaffolds. In addition, after 6 weeks of in vivo biocompatibility results in a model of rat indicated better tissue reactions for the scaffolds that contained hydroxyapatite. Overall, poly(3-hydroxybutyrate) composite scaffolds with 10% hydroxyapatite and 0.5% carbon nanotube showed optimal performances for the potential scaffold for hard tissue engineering application.

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