Serum BNP Concentration and Left Ventricular Mass in CAPD and Automated Peritoneal Dialysis Patients

Objective To compare ultrafiltration under continuous ambulatory peritoneal dialysis (CAPD) and automated PD (APD), disclosing potential effects on serum B-type natriuretic peptide (BNP) levels and echocardiographic findings. Patients and Methods This cross-sectional clinical study included 32 patients on CAPD and 30 patients on APD without clinical evidence of heart failure or hemodynamically significant valvular heart disease. Peritoneal equilibration tests, BNP levels, and echocardiographic measurements were performed in each subject. BNP measurements were also performed in 24 healthy control subjects. Results Patients on APD had lower ultrafiltration and higher values of BNP and left ventricular mass index (LVMI) compared with patients on CAPD (respectively: 775 ± 160 vs 850 ± 265 mL, p = 0.01; 253.23 ± 81.64 vs 109.42 ± 25.63 pg/mL, p = 0.001; 185.12 ± 63.50 vs 129.30 ± 40.95 g/m2, p = 0.001). This occurred despite higher mean dialysate glucose concentrations and far more extensive use of icodextrin in the APD group. Conclusion Treatment with APD is associated with higher plasma BNP levels and LVMI compared to CAPD. This may be the result of chronic fluid retention caused by lower ultra-filtration in APD patients.

Download Full-text

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

10.21203/rs.2.17102/v3 ◽

2020 ◽

Author(s):

Shasha Yu ◽

Yintao Chen ◽

Hongmei Yang ◽

Xiaofan Guo ◽

Liqiang Zheng ◽

...

Keyword(s):

Metabolic Syndrome ◽

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Left Ventricular ◽

Independent Effect ◽

Cross Sectional ◽

Ventricular Mass Index ◽

Ventricular Mass

Abstract Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS.Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH.Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

Download Full-text

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

10.21203/rs.2.17102/v1 ◽

2019 ◽

Author(s):

Shasha Yu ◽

Yintao Chen ◽

Hongmei Yang ◽

Xiaofan Guo ◽

Liqiang Zheng ◽

...

Keyword(s):

Metabolic Syndrome ◽

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Left Ventricular ◽

Independent Effect ◽

Cross Sectional ◽

Ventricular Mass Index ◽

Ventricular Mass

Abstract Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index for body surface area (LVMI) to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

Download Full-text

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

10.21203/rs.2.17102/v2 ◽

2019 ◽

Author(s):

Shasha Yu ◽

Yintao Chen ◽

Hongmei Yang ◽

Xiaofan Guo ◽

Liqiang Zheng ◽

...

Keyword(s):

Metabolic Syndrome ◽

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Left Ventricular ◽

Independent Effect ◽

Cross Sectional ◽

Ventricular Mass Index ◽

Ventricular Mass

Abstract Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

Download Full-text

MP500BODY COMPOSITION ASSESSED BY BIOIMPEDANCE CORRELATES WITH LEFT VENTRICULAR MASS INDEX IN STAGE 5 CKD PATIENTS TREATED WITH PERITONEAL DIALYSIS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw195.16 ◽

2016 ◽

Vol 31 (suppl_1) ◽

pp. i507-i507

Author(s):

Marcin Krzanowski ◽

Katarzyna Krzanowska ◽

Paulina Dumnicka ◽

Barbara Dudzik ◽

Eve Chowaniec ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Left Ventricular Mass ◽

Left Ventricular Mass Index ◽

Left Ventricular ◽

Ventricular Mass Index ◽

Ventricular Mass

Download Full-text

The association of ankle brachial index with left ventricular hypertrophy and left ventricular mass index: the Dong-gu study

VASA ◽

10.1024/0301-1526/a000289 ◽

2013 ◽

Vol 42 (4) ◽

pp. 284-291 ◽

Cited By ~ 1

Author(s):

Seong-Woo Choi ◽

Hye-Yeon Kim ◽

Hye-Ran Ahn ◽

Young-Hoon Lee ◽

Sun-Seog Kweon ◽

...

Keyword(s):

Left Ventricular Hypertrophy ◽

Left Ventricular Mass ◽

Ventricular Hypertrophy ◽

Left Ventricular Mass Index ◽

Ankle Brachial Index ◽

Intima Media Thickness ◽

Left Ventricular ◽

Baseline Survey ◽

Ventricular Mass Index ◽

Ventricular Mass

Background: To investigate the association between ankle-brachial index (ABI), left ventricular hypertrophy (LVH) and left ventricular mass index (LVMI) in a general population. Patients and methods: The study population consisted of 8,246 people aged 50 years and older who participated in the baseline survey of the Dong-gu Study conducted in Korea between 2007 and 2010. Trained research technicians measured LV mass using mode M ultrasound echocardiography and ABI using an oscillometric method. Results: After adjustment for risk factors and common carotid artery intima-media thickness (CCA-IMT) and the number of plaques, higher ABIs (1.10 1.19, 1.20 - 1.29, and ≥ 1.30) were significantly and linearly associated with high LVMI (1.10 - 1.19 ABI: β, 3.33; 95 % CI, 1.72 - 4.93; 1.20 - 1.29 ABI: β, 6.51; 95 % CI, 4.02 - 9.00; ≥ 1.30 ABI: β, 14.83; 95 % CI, 6.18 - 23.48). An ABI of 1.10 - 1.19 and 1.20 - 1.29 ABI was significantly associated with LVH (1.10 - 1.19 ABI: OR, 1.35; 95 % CI, 1.19 - 1.53; 1.20 - 1.29 ABI: OR, 1.59; 95 % CI, 1.31 - 1.92) and ABI ≥ 1.30 was marginally associated with LVH (OR, 1.73; 95 % CI, 0.93 - 3.22, p = 0.078). Conclusions: After adjustment for other cardiovascular variables and CCA-IMT and the number of plaques, higher ABIs are associated with LVH and LVMI in Koreans aged 50 years and older.

Download Full-text