Relationships between Dialysis Quantification and Normalized Protein Catabolic Rate in Peritoneal Dialysis

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 523-527 ◽  
Author(s):  
Robert A. Mactier ◽  
Maureen Perry ◽  
Lain S. Henderson
Keyword(s):  
Peritoneal Dialysis ◽  
Dietary Protein ◽  
Protein Intake ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Dietary Protein Intake ◽  
Mathematical Functions ◽  
Dialysis Dose ◽  
Appearance Rate ◽  
Catabolic Rate

Normalized protein catabolic rates (NPCR) and urea clearances (Kt/V urea) correlate significantly in peritoneal dialysis suggesting that the adequacy of dietary protein Intake and dialysis dose are Interrelated. However, both of these calculated parameters are mathematical functions of the normalized urea appearance rate (GN). NPCR, GN, Kt/V urea, total creatinine clearance, residual renal clearance, and peritoneal urea and creatinine clearances were determined In 29 stable peritoneal dialysis patients with no history of recent peritonitis or other catabolic illness. Multiple linear regression analysis showed that NPCR correlated closely with both GN (r=0.96; p<0.0001) and Kt/V urea (r=0.77; p<0.0001), whereas GN also correlated with Kt/V urea (r=0.66; p<0.0001). Total weekly creatinine clearances rather than Kt/V urea should be utilized in peritoneal dialysis to permit independent estimations of dialysis dose and NPCR, since both Kt/V and NPCR are related closely to GN. Total weekly creatinine clearances correlated with NPCR (r=0.59; p<0.0002), which supports the hypothesis that dietary protein Intake is dependent on the delivered dialysis dose.

Relationships between Dialysis Quantification and Normalized Protein Catabolic Rate in Peritoneal Dialysis

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 508-512 ◽  
Author(s):  
Robert A. Mactier ◽  
Maureen Perry ◽  
Lain S. Henderson
Keyword(s):  
Peritoneal Dialysis ◽  
Dietary Protein ◽  
Protein Intake ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Dietary Protein Intake ◽  
Mathematical Functions ◽  
Dialysis Dose ◽  
Appearance Rate ◽  
Catabolic Rate

Normalized protein catabolic rates (NPCR) and urea clearances (Kt/V urea) correlate significantly in peritoneal dialysis suggesting that the adequacy of dietary protein Intake and dialysis dose are Interrelated. However, both of these calculated parameters are mathematical functions of the normalized urea appearance rate (GN). NPCR, GN, Kt/V urea, total creatinine clearance, residual renal clearance, and peritoneal urea and creatinine clearances were determined In 29 stable peritoneal dialysis patients with no history of recent peritonitis or other catabolic illness. Multiple linear regression analysis showed that NPCR correlated closely with both GN (r=0.96; p<0.0001) and Kt/V urea (r=0.77; p<0.0001), whereas GN also correlated with Kt/V urea (r=0.66; p<0.0001). Total weekly creatinine clearances rather than Kt/V urea should be utilized in peritoneal dialysis to permit independent estimations of dialysis dose and NPCR, since both Kt/V and NPCR are related closely to GN. Total weekly creatinine clearances correlated with NPCR (r=0.59; p<0.0002), which supports the hypothesis that dietary protein Intake is dependent on the delivered dialysis dose.

Trends in intake and sources of dietary protein in Korean adults, 1998–2018

2021 ◽  
pp. 1-40
Author(s):  
Kyung Won Lee ◽  
Dayeon Shin
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Linear Regression Analysis ◽  
Recent Decade ◽  
Multiple Linear Regression Analysis ◽  
Dietary Protein Intake ◽  
Dietary Recall ◽  
The Past ◽  
Korean Adults ◽  
Source Plant

Abstract Although a decrease in carbohydrate intake and an increase in fat intake among Koreans have been reported, investigations of changes in protein intake have been limited. Thus, this study aimed to explore trends in the dietary intake of total, plant, and animal proteins overall and by sociodemographic subgroups in Korea over the past two decades. A total of 78,716 Korean adults aged ≥ 19 years who participated in the seven survey cycles of the Korea National Health and Nutrition Examination Survey 1998–2018 were included. Dietary protein intake, overall and by source, was calculated using a single 24-hour dietary recall data. Changes in dietary protein over 20 years were estimated using multiple linear regression analysis after adjusting for potential covariates. For total protein intake, a significant decrease was reported from 1998 to 2016–2018 (P for trendlinearity <0.001), whereas an increasing trend was observed from 2007–2009 to 2016–2018 (P for trendlinearity <0.001). In terms of protein intake by source, plant protein intake decreased while animal protein intake increased over the past two decades, indicating steeper trends during the recent decade (P for trendlinearity <0.001). These trends were more pronounced among younger adults and those with higher household income and education levels. These findings suggest that continuous monitoring of dietary protein intake overall and by source (plant vs. animal) across sociodemographic group is needed.

Predictors of Decline of Residual Renal Function in New Peritoneal Dialysis Patients

2003 ◽  
Vol 23 (3) ◽  
pp. 276-283 ◽  
Author(s):  
David W. Johnson ◽  
David W. Mudge ◽  
Joanna M. Sturtevant ◽  
Carmel M. Hawley ◽  
Scott B. Campbell ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Body Surface ◽  
Dietary Protein ◽  
Protein Intake ◽  
Residual Renal Function ◽  
Dietary Protein Intake

♦ Objective The aim of this study was to prospectively evaluate the risk factors for decline of residual renal function (RRF) in an incident peritoneal dialysis (PD) population. ♦ Design Prospective observational study of an incident PD cohort at a single center. ♦ Setting Tertiary-care institutional dialysis center. ♦ Participants The study included 146 consecutive patients commencing PD at the Princess Alexandra Hospital between 1 August 1995 and 1 July 2001 (mean age 54.8 ± 1.4 years, 42% male, 34% diabetic). Patients with failed renal transplants ( n = 26) were excluded. ♦ Main Measurements Timed urine collections ( n = 642) were performed initially and at 6-month intervals thereafter to measure RRF. The development of anuria was also prospectively recorded. ♦ Results The mean (±SD) follow-up period was 20.5 ± 14.8 months. The median slope of RRF decline was –0.05 mL/minute/month/1.73 m2. Using binary logistic regression, it was shown that the 50% of patients with more rapid RRF loss (< –0.05 mL/min/month/1.73 m2) were more likely to have had a higher initial RRF at commencement of PD [adjusted odds ratio (AOR) 1.83, 95% confidence interval (CI) 1.39 – 2.40] and a higher baseline dialysate/plasma creatinine ratio at 4 hours (D/P creat; AOR 44.6, 95% CI 1.05 – 1900). On multivariate Cox proportional hazards model analysis, time from commencement of PD to development of anuria was independently predicted by baseline RRF [adjusted hazard ratio (HR) 0.81, 95% CI 0.60 – 0.81], D/P creat (HR 2.87, 95% CI 2.06 – 82.3), body surface area (HR 6.23, 95% CI 1.53 – 25.5), dietary protein intake (HR 2.87, 95% CI 1.06 – 7.78), and diabetes mellitus (HR 1.65, 95% CI 1.00 – 2.72). Decline of RRF was independent of age, gender, dialysis modality, urgency of initiation of dialysis, smoking, vascular disease, blood pressure, medications (including angiotensin-converting enzyme inhibitors), duration of follow-up, and peritonitis rate. ♦ Conclusions The results of this study suggest that high baseline RRF and high D/P creat ratio are risk factors for rapid loss of RRF. Moreover, a shorter time to the onset of anuria is independently predicted by low baseline RRF, increased body surface area, high dietary protein intake, and diabetes mellitus. Such at-risk patients should be closely monitored for early signs of inadequate dialysis.

scholarly journals Estimating Dietary Protein Intake in Peritoneal Dialysis Patients: The Effect of Ethnicity

2018 ◽  
Vol 38 (5) ◽  
pp. 384-387 ◽  
Author(s):  
Surachet Vongsanim ◽  
Andrew Davenport
Keyword(s):  
Body Composition ◽  
Peritoneal Dialysis ◽  
Muscle Mass ◽  
South Asian ◽  
Dietary Protein ◽  
Protein Intake ◽  
South Asians ◽  
Dietary Protein Intake ◽  
Dialysis Patients ◽  
Multifrequency Bioimpedance

Kidney dialysis patients with sarcopenia have increased mortality. Clinical guidelines recommend peritoneal dialysis (PD) patients have a target daily protein intake to prevent sarcopenia. Protein intake is estimated from total daily urea losses in urine and peritoneal dialysate to assess the protein equivalent of nitrogen appearance rate adjusted for body weight (nPNA). Dietary habits differ among ethnic groups, so we reviewed nPNA and body composition in a multi-ethnic PD population. Body composition was measured with multifrequency bioimpedance in 598 patients (301 white, 136 black, 123 South-Asian, and 38 Asian-Pacific). South-Asians had a lower nPNA compared with white and black individuals (Randerson 0.80 ± 0.21 vs 0.88 ± 0.24 and 0.85 ± 0.24 g/kg/ day, Blumenkrantz 0.97 ± 0.14 vs 1.04 ± 0.22 and 0.99 ± 0.22 g/kg/ day, Bergström 0.87 ± 0.4 vs 0.95 ± 0.24 and 0.92 ± 0.24 g/kg/day all p < 0.001). South-Asians had lower weights (68.9 ± 14.9 vs 74.4 ± 16.6 and 73.5 ± 16.3 kg, p < 0.001), and although of similar body mass index (25.9 ± 4.9 vs 28.5 ± 4.9 and 26.5 ± 5.2 kg/m2), had both lower skeletal muscle and appendicular muscle mass indexed for height (9.08 ± 1.45 vs 9.89 ± 1.62 and 10.1 ± 1.85, p < 0.001; and 6.95 ± 1.39 vs 7.68 ± 1.48 and 7.67 ± 1.58 kg/m2p < 0.01). South-Asian patients had a lower calculated basal metabolic rate (BMR) (1,358 ± 218 vs 1,487 ± 257 and 1,489 ± 271 kcal/day, p < 0.001).Asian PD patients, particularly South-Asians, have lower dietary protein intakes when calculated by nPNA. However, South-Asians had lower measured muscle mass and calculated BMR. As such, dietary protein intake targets derived from studies in 1 ethnic group are not necessarily applicable for all patients, as those with less muscle mass and lower BMR may well need less daily protein intake to maintain homeostasis.

Association between lean mass and dietary protein intake in postmenopausal women

2016 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych ◽  
Roksolana Povorooznyuk
Keyword(s):  
Postmenopausal Women ◽  
Lean Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake
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