Alterations in rat erythrocyte membrane due to hexachlorocyclohexane (technical) exposure
1998 ◽
Vol 17
(11)
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pp. 638-642
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Keyword(s):
1 Hexachlorocyclohexane (HCH), an organochlorine pesticide having hydrophobic molecule is known to act on membranes. HCH mediated alterations in erythrocyte membrane occur through disorganization of the lipid bilayer. Therefore the changes in erythrocyte membrane fluidity, osmotic fragility and certain membrane bound enzymes were studied. Administration of HCH (technical) to rats at 5 mg/kg, orally, 5 days a week for 1, 2 and 3 months caused marked increase in erythrocyte membrane fluidity, osmotic fragility anddecreaseinlevelsofNa+, K+-ATPase, acetylcholinesterase in erythrocytes and glutathione in blood. 2 These changes indicate that HCH adversely affects membrane structure and function.
2008 ◽
Vol 146
(2)
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pp. 200-202
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1989 ◽
Vol 257
(2)
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pp. C270-C276
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1983 ◽
Vol 32
(7)
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pp. 1321-1323
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1991 ◽
Vol 196
(1)
◽
pp. 76-82
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1992 ◽
Vol 166
(1)
◽
pp. 296
1984 ◽
Vol 23
(2)
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pp. 97-113
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2009 ◽
Vol 162
(2)
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pp. 349-358
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Keyword(s):