The Syndrome of Thrombosis, Thrombocytopenia, and Recurrent Spontaneous Abortions Associated with Antiphospholipid Antibodies: Hughes Syndrome

Lupus ◽  
1996 ◽  
Vol 5 (5) ◽  
pp. 343-344 ◽  
Author(s):  
AE Gharavi ◽  
WA Wilson
Keyword(s):  
Autoimmune Diseases ◽  
Antiphospholipid Antibodies ◽  
Organ Damage ◽  
Spontaneous Abortions ◽  
Recurrent Spontaneous Abortions ◽  
Hughes Syndrome

aPL-associated thrombosis (Hughes syndrome) is widely recognized as a major cause of organ damage in autoimmune diseases. Beginning with the first symposium in 1984, international aPL symposia have facilitated research on aPL antibodies, and the clinical standardization of aPL tests. It is hoped that the present symposium will continue this tradition, because much remains to be learnt about the origin and pathogenicity of aPL antibodies. In addition, new insights are needed for more effective therapies to be developed.

scholarly journals Antiphospholipid syndrome accompanying systemic lupus erythematosus

2002 ◽  
Vol 55 (3-4) ◽  
pp. 89-96 ◽  
Author(s):  
Gorana Mitic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Antiphospholipid Antibodies ◽  
Lupus Anticoagulant ◽  
Clinical Manifestations ◽  
Spontaneous Abortions ◽  
Systemic Lupus ◽  
Recurrent Spontaneous Abortions ◽  
Thrombotic Complications

The aim of the study was the assessment of the prevalence of antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE). 72 patients with SLE had been investigated, 66 females and six males, aged 17 to 70 years, average 37,03. The presence of APA was determined using both ELISA assay for antiphospholipid antibodies ASSERACHROM APA by Diagnostica Stago and clotting tests for lupus anticoagulant: activated partial thromboplastin time (aPTT), tissue thromboplastin inhibition test (TTI) and dilute Russell viper venom time (dRVVT). Antiphospholipid antibodies have been found in 24 patients (33.44%), 10 of them were. with positive lupus anticoagulant tests, 6 of them were with positive ELISA test, while 8 of them had positive coagulation and immunological tests. Clinical manifestations that could be related to antiphospholipid syndrome were present in 22 patients (30.5%). The most common were thrombotic complications in 16 patients (22.25), recurrent spontaneous abortions in 7 patients (9.7%) and thrombocytopenia in 1 patient (1.39%). Presence of antiphospholipid syndrome was determined in 15 patients (20.83%). We can conclude that there is a significant correlation between presence of antiphospholipid antibodies and both thrombotic events and recurrent spontaneous abortions in SLE patients. Occurrence of thrombotic complications is in direct correlation with the level of antiphospholipid antibodies.

Association Between Familial Autoimmune Diseases and Recurrent Spontaneous Abortions

1994 ◽  
Vol 32 (2) ◽  
pp. 82-87 ◽  
Author(s):  
Andrea J. Shelton ◽  
James H. Harger ◽  
Janice S. Dorman ◽  
Lewis H. Kuller ◽  
Ronald E. Laporte ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Spontaneous Abortions ◽  
Recurrent Spontaneous Abortions

Immunogenetic and serological investigations in nonpregnant and in pregnant women with a history of recurrent spontaneous abortions

1994 ◽  
Vol 27 (2) ◽  
pp. 95-109 ◽  
Author(s):  
Gertrud Mueller-Eckhardt ◽  
Peter Mallmann ◽  
Jürgen Neppert ◽  
Annette Lattermann ◽  
Anette Melk ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Spontaneous Abortions ◽  
Recurrent Spontaneous Abortions ◽  
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