Hybrid Carcinoma of the Parotid Gland: An Extremely Rare Three Cases with an Immunohistochemical Analysis and a Review of the Literature

2021 ◽  
pp. 106689692110369
Author(s):  
Kimihide Kusafuka ◽  
Masaru Yamashita ◽  
Shoji Yamanaka ◽  
Kazuki Hirata ◽  
Aki Kubota ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Transitional Zone ◽  
Low Grade ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Neural Cell Adhesion ◽  
Female Case ◽  
Single Mass ◽  
Epithelial Myoepithelial Carcinoma ◽  
Cystic Disease Fluid Protein

Salivary hybrid carcinoma (HC) is defined as when two or more kinds of carcinoma exist at the same location in a single mass. We reestimated and examined three cases of salivary gland HC. Case 1 involved a 76-year-old male. Case 2 involved a 74-year-old female. Case 3 involved a 66-year-old male. Histologically, case 1 involved a combination of salivary duct carcinoma (SDC) and squamous cell carcinoma (SqCC). Immunohistochemically, the former was positive for gross cystic disease fluid protein (GCDFP)-15 and androgen receptor (AR). Case 2 involved a combination of SqCC and neuroendocrine carcinoma. Immunohistochemically the latter was positive for synaptophysin and neural cell adhesion molecule (NCAM). Case 3 involved a combination of SDC and epithelial–myoepithelial carcinoma (EMC). Immunohistochemically, the former was positive for GCDFP-15 and AR, whereas the inner cells of the latter were positive for cytokeratin 7, and the outer cells of the latter were positive for actin. Because of the transitional zone between SDC and EMC, it was speculated that high-grade SDC arose from low-grade EMC.

scholarly journals Hybrid Carcinoma of The Parotid Gland: A Report of Three Extremely Rare Cases with An Immunohistochemical Analysis and A Review of The Literature

2020 ◽  
Author(s):  
Kimihide Kusafuka ◽  
Masaru Yamashita ◽  
Shoji Yamanaka ◽  
Kazuki HIrata ◽  
Aki Kubota ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Smooth Muscle Actin ◽  
Immunohistochemical Analysis ◽  
Transitional Zone ◽  
Low Grade ◽  
High Grade ◽  
Alpha Smooth Muscle Actin ◽  
Duct Carcinoma ◽  
Japanese Male ◽  
Old Japanese

Abstract Background: Hybrid carcinoma (HC) of the salivary glands is defined as when two or more kinds of carcinoma exist at the same location in a single mass. Herein, we report 3 rare cases of salivary gland HC. Case Presentation: Case 1 involved an 86-year-old Japanese male. Case 2 involved a 70-year-old Japanese female. Case 3 involved a 66-year-old Japanese male. Histologically, case 1 involved a combination of salivary duct carcinoma (SDC) and squamous cell carcinoma (SqCC). Immunostaining indicated that the former was positive for gross cystic disease fluid protein (GCDFP)-15 and androgen receptor (AR), whereas the latter expressed cytokeratin (CK) 5/6 and p63. Case 2 involved a combination of SqCC and neuroendocrine carcinoma (NEC). Immunostaining indicated that the former was positive for CK5/6 and p40, whereas the latter was positive for synaptophysin and neural cell adhesion molecule. Case 3 involved a combination of SDC and epithelial-myoepithelial carcinoma (EMC). Immunostaining indicated that the former was positive for GCDFP-15 and AR, whereas the inner cells of the latter were positive for CK7, and the outer cells of the latter were positive for alpha-smooth muscle actin and p40. A transitional zone between the SDC and EMC existed in case 3. Conclusions: Therefore, we diagnosed them as parotid gland HC. This is the first report of a case of HC involving a combination of NEC and SqCC. In case 3, it was speculated that high-grade SDC arose from low-grade EMC. However, as HC is different from carcinoma with high-grade transformation, HC should be diagnosed carefully.

Low-Grade Salivary Duct Carcinoma

2004 ◽  
Vol 28 (8) ◽  
pp. 1040-1044 ◽  
Author(s):  
Margaret Brandwein-Gensler ◽  
Jos Hille ◽  
Beverly Y Wang ◽  
Mark Urken ◽  
Ronald Gordon ◽  
...  
Keyword(s):  
Salivary Duct Carcinoma ◽  
Low Grade ◽  
Salivary Duct ◽  
Duct Carcinoma

scholarly journals Salivary Duct Carcinoma of the Parotid Gland Originating from an Epithelial-Myoepithelial Carcinoma: Report of a Rare Case

2019 ◽  
Vol 14 (1) ◽  
pp. 283-289
Author(s):  
Yuichiro Hamamoto ◽  
Hiroshi Harada ◽  
Motoyuki Suzuki ◽  
Takashi Fujii ◽  
Shin-ichi Nakatsuka
Keyword(s):  
Parotid Gland ◽  
Rare Case ◽  
Salivary Duct Carcinoma ◽  
Myoepithelial Carcinoma ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Epithelial Myoepithelial Carcinoma

“Adenocarcinoma, not otherwise Specified”: A Diminishing Group of Salivary Carcinomas

1992 ◽  
Vol 101 (1) ◽  
pp. 102-104 ◽  
Author(s):  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Mario A. Luna
Keyword(s):  
Salivary Duct Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Salivary Duct ◽  
Duct Carcinoma ◽  
Not Otherwise Specified ◽  
Well Differentiated

As refinements in classification with clinicopathologic correlations proceed, the “adenocarcinomas, not otherwise specified” (NOS) of salivary tissue are reduced in number. Clinicopathologic entities such as salivary duct carcinoma, terminal duct carcinoma, and epimyoepithelial carcinoma, formerly in the NOS category, are examples of this process. There remain, however, adenocarcinomas of salivary tissues that cannot be accommodated in conventional classifications. They are the least common of salivary carcinomas and manifest a cytoarchitecture ranging from a well-differentiated, low-grade appearance to high-grade, invasive lesions. This report addresses this group of carcinomas for which the NOS designation is still applicable.

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