Short-term Efficacy of Ultrasonographic Guidance for Intra-articular Corticosteroid Injection in Hallux Rigidus: A Single-Blind Randomized Controlled Trial

Background: Multiple considerations should be taken before standardizing a clinical procedure such as efficacy, safety, or the cost. The aim of this study was to compare the effects of landmark-guided vs ultrasonography-guided intra-articular injection of corticosteroid into the first metatarsophalangeal joint cavity to reduce pain and dysfunction in patients with hallux rigidus. Methods: We carried out a single-blind randomized controlled trial with 2 parallel arms in an outpatient clinic affiliated with a medical university. In total, 50 participants (35 women) with the mean (SD) age of 49.8 (10.3) years were randomly allocated to landmark-guided or ultrasonography-guided groups (each n = 25). Each patient received a single intra-articular injection of 40-mg methylprednisolone plus 1 mL lidocaine into the affected first metatarsophalangeal joint. The primary outcome was joint pain and the secondary outcome was the American Orthopaedic Foot & Ankle Society score. We measured the outcomes at baseline and 2 and 6 weeks after the intervention. Results: Six weeks after the injections, there were no statistically significant differences between the study groups in pain reduction and increase in the American Orthopaedic Foot & Ankle Society scores ( P = .131 and .241, respectively). We did not find any complications for the injections in both groups. There were statistically significant changes within each group in pain and the scores for the landmark ( P < .001, and P = .007), and ultrasonography groups (both P < .001). Conclusion: Landmark guidance is as effective as ultrasonographic guidance for intra-articular injection in patients with hallux rigidus. A single intra-articular injection of 40 mg methylprednisolone plus 1 mL lidocaine is an efficient and safe therapeutic measure for decreasing joint pain and maintaining its function, at least for 6 weeks. Level of Evidence: Level I, high-quality prospective randomized study.

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Arthrodesis or Total Replacement Arthroplasty for Hallux Rigidus: A Randomized Controlled Trial

Foot & Ankle International ◽

10.1177/107110070502600904 ◽

2005 ◽

Vol 26 (9) ◽

pp. 680-690 ◽

Cited By ~ 156

Author(s):

J. N. Alastair Gibson ◽

Colin E. Thomson

Keyword(s):

Randomized Controlled Trial ◽

Total Joint Replacement ◽

Controlled Trial ◽

Metatarsophalangeal Joint ◽

Primary Outcome Measure ◽

Hallux Rigidus ◽

Cost Ratio ◽

First Metatarsophalangeal Joint ◽

Randomized Controlled ◽

Replacement Arthroplasty

Background: Arthrodesis is the current treatment for end-stage hallux rigidus, although there are many reports advocating total joint replacement arthroplasty. The aim of this randomized controlled trial was to evaluate clinical outcomes after first metatarsophalangeal joint (MTPJ) arthrodesis and replacement arthroplasty. Methods: Between November, 1998, and January 2001, 63 patients between the ages of 34 and 77 years, with unilateral or bilateral MTPJ arthritis were recruited and randomly selected to have either MTPJ arthrodesis or arthroplasty. Twenty-two patients (38 toes) had arthrodesis and 27 patients (39 toes) had arthroplasty. A single surgeon performed all surgery. The primary outcome measure determining successful surgery was a decrease in pain as measured on a Visual Analogue Scale (VAS). Functional outcome was assessed at 6 months and 1 and 2 years. Cost data were simultaneously collected. Results: At 24 months, pain improved in both groups ( p < 0.001), but there were significantly greater improvements after arthrodesis ( p = 0.01). All 38 arthrodeses united at a mean dorsiflexion angle of 26 degrees, with few complications. In contrast, in the arthroplasty group, six of the 39 inserted implants had to be removed because of phalangeal component loosening. In the remainder the range of motion gained was poor, and the patients tended to bear weight on the outer border of their foot. The cost ratio was 2:1 in favor of arthrodesis. Conclusions: Outcomes after arthrodesis were better than those after arthroplasty. The results were partially attributable to an unacceptably high incidence of loosening of the phalangeal components, which resulted in removal of the implants. However, even when data from the failures were excluded, arthrodesis was clearly preferred by most patients.

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Post-operative hypocalcaemia following open thyroidectomy for benign multinodular goiters using FOCUS harmonic scalpel versus conventional suture ligation technique for hemostasis - a prospective, single-blind, randomized controlled trial

Endocrine Abstracts ◽

10.1530/endoabs.56.p1017 ◽

2018 ◽

Author(s):

Sadaf Zehra ◽

Sughra Parveen

Keyword(s):

Randomized Controlled Trial ◽

Harmonic Scalpel ◽

Controlled Trial ◽

Open Thyroidectomy ◽

Suture Ligation ◽

Randomized Controlled ◽

Single Blind

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Correction to: The effect of intraoperative autofluorescence monitoring on unintentional parathyroid gland excision rates and postoperative PTH concentrations—a single-blind randomized-controlled trial

Endocrine ◽

10.1007/s12020-021-02765-3 ◽

2021 ◽

Author(s):

Theodosios S. Papavramidis ◽

Angeliki Chorti ◽

George Tzikos ◽

Panagiotis Anagnostis ◽

Panteleimon Pantelidis ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Parathyroid Gland ◽

Controlled Trial ◽

Randomized Controlled ◽

Single Blind

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The Therapeutic Effects of Acupuncture on Patients with Chronic Neck Myofascial Pain Syndrome: A Single-Blind Randomized Controlled Trial

The American Journal of Chinese Medicine ◽

10.1142/s0192415x10008299 ◽

2010 ◽

Vol 38 (05) ◽

pp. 849-859 ◽

Cited By ~ 29

Author(s):

Mei-Yuan Sun ◽

Ching-Liang Hsieh ◽

Yung-Yen Cheng ◽

Hung-Chang Hung ◽

Tsai-Chung Li ◽

...

Keyword(s):

Quality Of Life ◽

Randomized Controlled Trial ◽

Myofascial Pain ◽

Short Form ◽

Controlled Trial ◽

Pain Syndrome ◽

Myofascial Pain Syndrome ◽

Randomized Controlled ◽

Single Blind

Chronic neck myofascial pain syndrome (MPS) is a common disorder seen in clinics. There is no gold standard method to treat myofascial pain. We investigated the effects of acupuncture on patients with chronic neck MPS by a single-blind randomized controlled trial. A total of 35 patients were randomly allocated to an acupuncture group (AG) or a sham acupuncture group (SG). Each subject received acupuncture treatment twice per week for three consecutive weeks. The primary outcome measure was quality of life as assessed with Short Form-36, and secondary outcome measures were neck range of motion (ROM), motion-related pain, and Short-Form McGill Pain Questionnaire (SF-MPQ), as determined by a blinded investigator. The clinical assessments were made before treatment (BT) and after six acupuncture treatments (AT), as well as four weeks (F1) and 12 weeks (F2) after the end of the treatment. A total of 34 patients completed the trial. The results indicated that there is no significant difference in the ROM, motion-related pain, and SF-MPQ scores between AG and SG at AT, F1 and F2 (all p > 0.05). However, AG has greater improvement in physical functioning and role emotional of Short Form-36 quality of life at F2. The results indicate that acupuncture may be used to improve the quality of life in patients with chronic neck MPS.

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