Retinal obliterative vasculitis associated to contralateral retinal neovascularization in membranoproliferative glomerulonephritis

2021 ◽  
pp. 112067212110143
Author(s):  
Michele Nicolai ◽  
Alessandro Franceschi ◽  
Nicola Vito Lassandro ◽  
Paolo Pelliccioni ◽  
Luca Danieli ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Membranoproliferative Glomerulonephritis ◽  
Vision Loss ◽  
Vascular Occlusion ◽  
Retinal Neovascularization ◽  
Vein Occlusion ◽  
Retinal Vascular Occlusion ◽  
Contralateral Eye ◽  
Peculiar Case

Purpose: To report our experience with a peculiar case of asynchronous bilateral retinal vascular occlusion in a patient suffering from membranoproliferative glomerulonephritis. Case report: A 57-year-old dialysed male affected by membranoproliferative glomerulonephritis who underwent kidney transplantation complained of a sudden vision loss in his right eye (RE). His best-corrected visual acuity (BCVA) was 20/40 in RE and 20/20 in the left eye (LE); ophthalmological and fluorangiographic examinations revealed unilateral retinal obliterative vasculitis with panuveitis and apparent sparing of contralateral eye. About 6 months later the patient developed a branch retinal vein occlusion associated with a papillary neovascular membrane in LE. Corticosteroid therapy was administered and immunosuppressant dosage was increased with macular oedema reduction in both events. Conclusion: We report a case of unilateral retinal obliterative vasculitis and subsequent contralateral retinal neovascularization and branch retinal vein occlusion in a patient affected by membranoproliferative glomerulonephritis.

scholarly journals Clinical profile and management of vitreous hemorrhage in tertiary eye care centre in Nepal

2020 ◽  
Vol 12 (1) ◽  
pp. 99-105
Author(s):  
Laxmi Devi Manandhar ◽  
Raba Thapa ◽  
Govinda Poudyal
Keyword(s):  
Emergency Department ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vision Loss ◽  
Vitreous Hemorrhage ◽  
Sudden Onset ◽  
Age Group ◽  
Care Centre ◽  
Vein Occlusion ◽  
Common Etiology

Introduction: Vitreous hemorrhage is one of the most common diseases presenting to emergency department and leading cause of painless vision loss. Objectives: To determine the profile of vitreous hemorrhage in patients presented to Outpatient Department (OPD) and emergency Department of Tilganga Institute of Ophthalmology (TIO). Materials and methods: This is a hospital based observational non interventional descriptive study. Total 198 patients were enrolled who visited OPD and Emergency department of TIO from August 1st 2012 to July 30th 2013. Result: Total 198 patients (201 eyes) were enrolled for the study, out of which 144 were male and 54 females. 195 were unilateral and 3 bilateral cases. Most common age group of presentation of vitreous hemorrhage was 51-60 years (24.75%). Most common presenting complaint was sudden onset of decreased vision (95%). Most common etiology of vitreous hemorrhage was branch retinal vein occlusion (22.38%). Among the total subjects, 57.7% of the patient were managed with medical therapy, 35.8% surgically and 6.47 % with combined medical and surgical treatment. Conclusion: Branch retinal vein occlusion (BRVO) is the most common cause of vitreous hemorrhage. Diabetes and hypertension are the most commonly associated systemic illnesses.

scholarly journals Incomplete Treatment Response, Treatment Resistance, Pharmaceutical Changes and Combined Treatments in Branch Retinal Vein Occlusion and Macular Edema

2019 ◽  
pp. 108-111
Keyword(s):  
Macular Edema ◽  
Treatment Response ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vision Loss ◽  
Combined Treatment ◽  
Treatment Resistance ◽  
Vein Occlusion ◽  
Anti Vegf ◽  
Incomplete Treatment

Branch retinal vein occlusion (BRVO) is the second most common retinal vascular disease after diabetic retinopathy. Vision loss varies depending on the affected area. The main causes of vision loss in BRVO are macular edema and macular ischemia. Anti-VEGF agents are preferred in the treatment of macular edema due to BRVO because of the increase in visual acuity. Although anti-VEGF therapy provides an early response, in some cases macular edema is resistant to the treatment. In this review, incomplete treatment response, treatment resistance, pharmaceutical changes, and combined treatment are mentioned in cases with BRVO and macular edema.

scholarly journals Ischemia-induced spreading depolarization in the retina

2016 ◽  
Vol 36 (9) ◽  
pp. 1579-1591 ◽  
Author(s):  
Anja I Srienc ◽  
Kyle R Biesecker ◽  
Angela M Shimoda ◽  
Joanna Kur ◽  
Eric A Newman
Keyword(s):  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vision Loss ◽  
Nmda Antagonist ◽  
Retinal Vessel ◽  
Vessel Occlusion ◽  
Spreading Depolarization ◽  
Vein Occlusion ◽  
Retinal Vessel Occlusion

Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now that spreading depolarization episodes are generated in the in vivo rat retina following retinal vessel occlusion produced by photothrombosis. The properties of retinal spreading depolarization are similar to those of cortical spreading depolarization. Retinal spreading depolarization waves propagate at a velocity of 3.0 ± 0.1 mm/min and are associated with a negative shift in direct current potential, a transient cessation of neuronal spiking, arteriole constriction, and a decrease in tissue O2 tension. The frequency of retinal spreading depolarization generation in vivo is reduced by administration of the NMDA antagonist MK-801 and the 5-HT(1D) agonist sumatriptan. Branch retinal vein occlusion is a leading cause of vision loss from vascular disease. Our results suggest that retinal spreading depolarization could contribute to retinal damage in acute retinal ischemia and demonstrate that pharmacological agents can reduce retinal spreading depolarization frequency after retinal vessel occlusion. Blocking retinal spreading depolarization generation may represent a therapeutic strategy for preserving vision in branch retinal vein occlusion patients.

scholarly journals Long-Term Follow-Up Case of Multiple Retinal Arterial Macroaneurysms Developing Branch Retinal Vein Occlusion following Ruptured Macroaneurysm

2016 ◽  
Vol 7 (1) ◽  
pp. 243-248 ◽  
Author(s):  
Yuya Terubayashi ◽  
Teruyo Kida ◽  
Masanori Fukumoto ◽  
Jun Sugasawa ◽  
Seita Morishita ◽  
...  
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vision Loss ◽  
Vein Occlusion ◽  
Long Term Follow Up ◽  
Vascular Arcade ◽  
Arteriovenous Crossing

Purpose: Retinal arterial macroaneurysm (RAM) has been reported in association with branch retinal vein occlusion (BRVO), and usually BRVO precedes RAM. We present a long-term follow-up case report of unilateral multiple RAMs that developed BRVO following ruptured RAM in the same retinal quadrant. Case Presentation: An 80-year-old woman presented with floaters in her right eye in June 2012. Visual acuity (VA) was 20/25 in her right eye with posterior capsular opacity. Her fundus showed the first ruptured RAM at the superotemporal vascular arcade with subinternal limiting membrane and subretinal hemorrhages not involving the macula. These were absorbed gradually with a VA of 20/20. After 2 years, the second RAM at the proximal superotemporal vascular arcade developed and impending BRVO occurred with macular edema at the distal site of the RAM. With the RAM located close to the arteriovenous crossing, her VA was dropped to 20/60. Intravitreal injection of ranibizumab was performed and macular edema was resolved with improved vision of 20/30. Three months later, she realized a sudden vision loss of 2/200. Her posterior pole showed massive pre- and subretinal hemorrhages, and vitrectomy was performed. The source of bleeding was the third RAM’s rupture in a different artery. Her vision improved to 20/30. The unaffected eye showed no RAMs. Conclusion: We experienced a long-term follow-up case of multiple RAMs showing different courses. We should cautiously note that BRVO can occur following RAM at the arteriovenous crossing.

Development of a New Mouse Model of Branch Retinal Vein Occlusion and Retinal Neovascularization

2007 ◽  
Vol 51 (4) ◽  
pp. 251-257 ◽  
Author(s):  
Han Zhang ◽  
Koh-Hei Sonoda ◽  
Hong Qiao ◽  
Toru Oshima ◽  
Toshio Hisatomi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Retinal Neovascularization ◽  
Vein Occlusion
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