Sutureless “Contact Lens Sandwich” Technique for Amniotic Membrane Therapy of Central Corneal Ulcers

2021 ◽  
pp. 112067212110490
Author(s):  
Saverio V. Luccarelli ◽  
Edoardo Villani ◽  
Stefano Lucentini ◽  
Francesco Bonsignore ◽  
Matteo Sacchi ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Contact Lens ◽  
Low Cost ◽  
Healing Time ◽  
Amniotic Membrane Transplantation ◽  
Recurrence Rates ◽  
Sandwich Technique ◽  
Corneal Ulcers ◽  
Bandage Contact Lens ◽  
Ring Complex

Purpose To describe a new technique for sutureless and glue-free amniotic membrane transplantation (AMT) and to investigate its effectiveness to treat corneal persistent epithelial defects (PEDs), compared to bandage contact lens (BCL) application alone. Methods We performed AMT with “contact lens sandwich technique” (CLS-AMT) in 8 consecutive patients with central/para-central (up to 4.00 mm from the geometrical centre) PED/ulceration and we retrospectively compared the results with 11 BCL procedures. Results The procedures were performed successfully with no complications. CLS-AMT showed significantly shorter healing time than BCL (24.0  ±  19.1 vs 42.9  ±  14.6 days; P < 0.05, Mann-Whitney test). Recurrence rates were 12% and 27% for CLS-AMT and BCL, respectively. Conclusion CLS-AMT technique, based on the suction effect due to the superposition of a bandage contact lens on the AM-ring complex, represents a quick, low cost, easy to perform and nearly non-invasive AMT technique. This approach is able to provide adequate fixation of AM, and it seems to be a safe and effective treatment for patients with PEDs.

scholarly journals Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Ting Zhang ◽  
Yuexin Wang ◽  
Yanni Jia ◽  
Dongle Liu ◽  
Suxia Li ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Amniotic Membrane ◽  
Ulcer Healing ◽  
Laser Scanning ◽  
Corneal Ulcer ◽  
Anterior Segment ◽  
Healing Time ◽  
Stevens Johnson Syndrome ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers.Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT).Results. The primary diseases were herpes simplex keratitis (8 eyes), corneal graft ulcer (2 eyes), and Stevens-Johnson syndrome (1 eye). All epithelial flaps were intact following surgery, without shedding or displacement. Mean ulcer healing time was10.8±3.1days, with a healing rate of 91%. Vision significantly improved from 1.70 to 0.82 log MAR (P=0.001). A significant decrease in inflammatory cell infiltration and corneal stromal edema was revealed 2 months postoperatively by confocal microscopy and AS-OCT. Corneal ulcer recurred in 1 eye. None of the patients developed major complications.Conclusion. Active pedicle epithelial flap transposition combined with AMT is a simple and effective treatment for nonhealing corneal ulcers.

scholarly journals Comparison of amniotic membrane transplantation with and without cultured limbal epithelium for persistent corneal ulcers

2021 ◽  
Vol 35 (1) ◽  
pp. 739-745
Author(s):  
Rozaliya Hristova ◽  
Yani Zdravkov ◽  
Georgi Markov ◽  
Davide Borroni ◽  
Alexander Oscar ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers ◽  
Limbal Epithelium

Role of multilayered amniotic membrane transplantation for the treatment of resistant corneal ulcers in North India

2013 ◽  
Vol 34 (3) ◽  
pp. 485-491 ◽  
Author(s):  
Shalini Mohan ◽  
Ina Budhiraja ◽  
Amit Saxena ◽  
Perwez Khan ◽  
S. K. Sachan
Keyword(s):  
Amniotic Membrane ◽  
North India ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

A multicenter retrospective study on cryopreserved amniotic membrane transplantation for the treatment of complicated corneal ulcers in the dog

2019 ◽  
Vol 22 (5) ◽  
pp. 695-702 ◽  
Author(s):  
Daniel Costa ◽  
Marta Leiva ◽  
Fernando Sanz ◽  
Victoria Espejo ◽  
Javier Esteban ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

scholarly journals Efficacy of Amniotic Membrane Transplantation for the Treatment of Corneal Ulcers

Cornea ◽  
2020 ◽  
Vol 39 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Kaspar Schuerch ◽  
Andrea Baeriswyl ◽  
Beatrice E. Frueh ◽  
Christoph Tappeiner
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

Amniotic Membrane Transplantation in Refractory Neurotrophic Corneal Ulcers

Cornea ◽  
2005 ◽  
Vol 24 (6) ◽  
pp. 654-660 ◽  
Author(s):  
Sudarshan Khokhar ◽  
Tanie Natung ◽  
Parul Sony ◽  
Namrata Sharma ◽  
Nutan Agarwal ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

scholarly journals Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Selcuk Kara ◽  
Sedat Arikan ◽  
Ismail Ersan ◽  
Arzu Taskiran Comez
Keyword(s):  
Surgical Technique ◽  
Fibrin Glue ◽  
Amniotic Membrane ◽  
Contact Lens ◽  
Corneal Thickness ◽  
Good Alternative ◽  
Corneal Perforation ◽  
Bandage Contact Lens ◽  
Membrane Patch ◽  
Successful Repair

Purpose. To describe a surgical technique using amniotic membrane transplant (AMT) with fibrin glue (FG) for treating smaller corneal perforations more practically and appropriately filling the defect.Method. A patient with noninfectious central corneal perforation, in 1 mm in diameter, was treated with FG-assisted AMT-plug. An AMT was folded in on itself twice by using FG then a small piece of this FG-AMT mixture was cut to maintain an appropriate plug for the site of the corneal perforation. The FG-assisted AMT-plug was placed in the perforation area by using FG. An amniotic membrane patch was placed over the plug, which was then secured by a bandage contact lens.Result. Surgery to restore corneal stromal thickness without recurrence of perforation.Conclusion. The FG-assisted AMT-plug allowed a successful repair of 1 mm in diameter corneal perforation. This technique was easily performed, thus seeming to be a good alternative to treat corneal perforations with restoring corneal thickness.

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