Forearm blood flow measured by venous occlusion plethysmography in healthy subjects and in women with postmastectomy oedema

We applied near-infrared spectroscopy (NIRS) for the simultaneous measurement of forearm blood flow (FBF) and oxygen consumption (VO2) in the human by inducing a 50-mmHg venous occlusion. Eleven healthy subjects were studied both at rest and after hand exercise during vascular occlusion. FBF was also measured by strain-gauge plethysmography. FBF measured by NIRS was 1.9 +/- 0.8 ml.100 ml-1.min-1 at rest and 8.2 +/- 2.9 ml.100 ml-1.min-1 after hand exercise. These values showed a correlation (r = 0.94) with those obtained by the plethysmography. VO2 values were 4.6 +/- 1.3 microM O2 x 100 ml-1.min-1 at rest and 24.9 +/- 11.2 microM O2 x 100 ml-1.min-1 after hand exercise. The scatter of the FBF and VO2 values showed a good correlation between the two variables (r = 0.93). The results demonstrate that NIRS provides the particular advantage of obtaining the contemporary evaluation of blood flow and VO2, allowing correlation of these two variables by a single maneuver without discomfort for the subject.

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Parathyroid Hormone's Acute Effect on Vasodilatory Function

Clinical Medicine Insights Endocrinology and Diabetes ◽

10.4137/cmed.s4650 ◽

2010 ◽

Vol 3 ◽

pp. CMED.S4650 ◽

Cited By ~ 2

Author(s):

P. Farahnak ◽

L. Lind ◽

K. Mattala ◽

I-L. Nilsson

Keyword(s):

Cardiovascular Disease ◽

Blood Flow ◽

Healthy Subjects ◽

Forearm Blood Flow ◽

Acute Effect ◽

Venous Occlusion ◽

Arterial Infusion ◽

Resistance Vessels ◽

Vasodilatory Function ◽

Pth Level

Parathyroid hormone (PTH) seems to affect the risk of cardiovascular disease. The aim of the present study was to investigate PTH's acute effect on endothelial vasodilatory function in forearm resistance vessels. Ten healthy subjects underwent forearm venous occlusion plethysmography. We measured forearm blood flow at baseline and at a stable, locally increased PTH level after intra-arterial infusion of metacholine and nitroprusside. The contralateral arm served as a control. Ionized calcium (Ca++) and PTH values were normal in all subjects at baseline (1.26 ± 0.02 mM/L, 3.6 ± 1.2 pM/L). After 30 minutes of PTH infusion, the PTH level increased in the active arm (13.8 ± 4.0 pM/L P < 0.01), while the Ca++ level was unchanged (1.25 ± 0.04; mM/L). Both the PTH and the Ca++ level in the contralateral arm remained unchanged, which indicates no systemic influence. The endothelial-dependent vasodilation was inversely correlated to the Ca++ level at baseline (r = −0.75, P < 0.05) and after PTH infusion (r = −0.68, P < 0.05). The vasodilatory function was not affected during PTH-infusion.

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Blood Flow in the Calf During and After Exercise: Measurements with Doppler Ultrasound and Venous Occlusion Plethysmography in Healthy Subjects and in Patients with Arterial Occlusive Disease

Angiology ◽

10.1177/000331978203300302 ◽

1982 ◽

Vol 33 (3) ◽

pp. 146-160 ◽

Cited By ~ 13

Author(s):

P.J.L.M. Bernink ◽

J. Lubbers ◽

G.J. Barendsen ◽

J. van den Berg

Keyword(s):

Blood Flow ◽

Doppler Ultrasound ◽

Healthy Subjects ◽

Venous Occlusion ◽

Arterial Occlusive Disease ◽

Occlusive Disease ◽

Venous Occlusion Plethysmography

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Inhibition of vascular ATP-sensitive K+channels does not affect reactive hyperemia in human forearm

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00315.2002 ◽

2003 ◽

Vol 284 (2) ◽

pp. H711-H718 ◽

Cited By ~ 14

Author(s):

H. M. Omar Farouque ◽

Ian T. Meredith

Keyword(s):

Blood Flow ◽

Adaptive Response ◽

Healthy Subjects ◽

Forearm Blood Flow ◽

Reactive Hyperemia ◽

Venous Occlusion ◽

Channel Inhibition ◽

Human Forearm ◽

Hyperemic Response

The extent to which ATP-sensitive K+ channels contribute to reactive hyperemia in humans is unresolved. We examined the role of ATP-sensitive K+channels in regulating reactive hyperemia induced by 5 min of forearm ischemia. Thirty-one healthy subjects had forearm blood flow measured with venous occlusion plethysmography. Reactive hyperemia could be reproducibly induced ( n = 9). The contribution of vascular ATP-sensitive K+ channels to reactive hyperemia was determined by measuring forearm blood flow before and during brachial artery infusion of glibenclamide, an ATP-sensitive K+ channel inhibitor ( n = 12). To document ATP-sensitive K+ channel inhibition with glibenclamide, coinfusion with diazoxide, an ATP-sensitive K+ channel opener, was undertaken ( n = 10). Glibenclamide did not significantly alter resting forearm blood flow or the initial and sustained phases of reactive hyperemia. However, glibenclamide attenuated the hyperemic response induced by diazoxide. These data suggest that ATP-sensitive K+ channels do not play an important role in controlling forearm reactive hyperemia and that other mechanisms are active in this adaptive response.

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