scholarly journals Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer

2019 ◽  
Vol 18 ◽  
pp. 153473541983435
Author(s):  
Chia-Chen Chang ◽  
Kuo-Wei Bi ◽  
Hung-Jen Lin ◽  
Yuan-Chih Su ◽  
Wen-Ling Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Herbal Medicine ◽  
Head And Neck ◽  
Chinese Herbal Medicine ◽  
Cumulative Incidence ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Chinese Herbal ◽  
Kaplan Meier

Background: Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). Objectives: The aim of this study is to evaluate whether Chinese Herbal Medicine (CHM) is correlated with reduced occurrence of second primary cancer (SPC) of head and neck (H&N) in patients with esophageal cancer (EC). Method: We identified 15,546 patients who were diagnosed with esophageal cancer between Jan 1, 2000, and Dec 31, 2010. The patients with H&N cancer before receiving CHM were excluded. After the selection and matching process, both CHM and non-CHM cohorts each contained 850 individuals. We compared the cumulative incidence of SPC of H&N with or without CHM treatment in patients with EC by the Kaplan-Meier method. NodeXL is used to run a network analysis of CHM to examine the association between herbs and formulas. Results: Compared with non-CHM users, CHM-users showed a reduced incidence rate of SPC of H&N among the patients with EC. Reduced cumulative incidence of SPC of H&N among patients with EC was noted in the CHM cohort compared to the non-CHM cohort. The most commonly used single herbs and formulas were associated with reducing SPC occurrence. Conclusion: We propose that CHM as an adjuvant therapy may prevent the occurrence of SPC of H&N in patients with EC.

scholarly journals Identification of Herb Pairs in Esophageal Cancer

2017 ◽  
Vol 24 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Yu-Mei Cai ◽  
Hui Zhu ◽  
Jing-Xiu Niu ◽  
Lin Bing ◽  
Zhen Sun ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Overall Survival ◽  
Esophageal Cancer ◽  
Herbal Medicine ◽  
Association Rules ◽  
Chicken Gizzard ◽  
Chinese Herbal ◽  
Kaplan Meier ◽  
Specific Cancer ◽  
Cancer Types

Background: Chinese herbal medicine (CHM) is used widely to treat various diseases, including cancer. However, effective herb pairs for treating specific cancer types have so far not been identified. Here, we aimed to calculate the survival benefits of herb pairs by cluster analysis, association rules, and survival evaluation in patients with esophageal cancer (EC) treated with CHM. Patients and Methods: 59 patients with EC who received 176 prescriptions including 178 types of herbs were enrolled into the study. The herb pairs were identified by both cluster analysis and association rules. Overall survival (OS) was estimated by the Kaplan-Meier method. Results: Eight groups of herb pairs were identified by cluster analysis, and 4 groups of herb pairs were identified by association rules. Of these, 3 groups of herb pairs were identified by both methods. OS estimation showed that the pair of chicken gizzard-membrane/Astragalus was associated with improved survival in patients with EC treated with CHM. Conclusion: Patients who received prescriptions containing the pair of chicken gizzard-membrane and Astragalus had improved OS compared with patients who received prescriptions lacking this pair.

Trends over three decades of the risk of second primary cancer among patients with head and neck cancer

Oral Oncology ◽  
2013 ◽  
Vol 49 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Jérémie Jégu ◽  
Florence Binder-Foucard ◽  
Christian Borel ◽  
Michel Velten
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

scholarly journals Chinese Herbal Medicine Therapy Reduces the Risks of Overall and Anemia-Related Mortalities in Patients With Aplastic Anemia: A Nationwide Retrospective Study in Taiwan

2021 ◽  
Vol 12 ◽  
Author(s):  
Mu-Lin Chiu ◽  
Yu-Lung Hsu ◽  
Chao-Jung Chen ◽  
Te-Mao Li ◽  
Jian-Shiun Chiou ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Aplastic Anemia ◽  
Chinese Herbal Medicine ◽  
Large Scale ◽  
Salvia Miltiorrhiza ◽  
Bone Marrow Failure ◽  
Complementary Therapy ◽  
Population Based ◽  
Chinese Herbal ◽  
Kaplan Meier

Aplastic Anemia (AA) is a rare but fatal hematologic disease that may occur at any age and especially higher in Asia. We investigated whether Chinese herbal medicine (CHM) is beneficial to AA patients as a complementary therapy using a nationwide population-based database in Taiwan between 2000–2016. Patient survival was estimated by Kaplan‒Meier survival analyses and Cox proportional-hazard model. CHM-users presented lower risks of overall and anemia-related mortalities when compared to non-users. The risk of overall mortality for CHM-users in AA patients was 0.70-fold [adjusted hazard ratio (aHR): 0.70, 95% confidence interval (CI): 0.66-0.74, p < 0.001). The risk of anemia-related mortality was lower in CHM-users when compared to non-users (aHR: 0.46, 95% CI: 0.32-0.67, p < 0.001). The association rule analysis revealed that CHM pairs were Ban-Zhi-Lian (BZL; Scutellaria barbata D. Don)→Bai-Hua-She-She-Cao (BHSSC; Oldenlandia diffusa (Willd.) Roxb.), followed by Dang-Gui (DG; Angelica sinensis (Oliv.) Diels)→Huang-Qi (HQi; Astragalus membranaceus (Fisch.) Bunge), and Xian-He-Cao (XHC; Agrimonia pilosa f. borealis (Kitag.) Chu)→Gui-Pi-Tang (GPT). Network analysis showed that BZL, BHSSC, DG, HQi, XHC, GPT, and Dan-Shen (DanS; Salvia miltiorrhiza var. charbonnelii (H.Lév.) C.Y.Wu) were commonly used CHMs for AA patients. Therefore, further studies for these commonly prescribed herbs are needed in functional investigations in hematopoiesis-stimulating effect and large-scale randomized controlled trials (RCT) in bone marrow failure related diseases.

scholarly journals Risk of Second Primary Cancer among Esophageal Cancer Patients: a Pooled Analysis of 13 Cancer Registries

2008 ◽  
Vol 17 (6) ◽  
pp. 1543-1549 ◽  
Author(s):  
S.-C. Chuang ◽  
M. Hashibe ◽  
G. Scelo ◽  
D. H. Brewster ◽  
E. Pukkala ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Cancer Registries ◽  
Pooled Analysis ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Head and neck second primary cancer rates in the human papillomavirus era: A population-based analysis

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E873-E883 ◽  
Author(s):  
Dayssy Alexandra Diaz ◽  
Isildinha M. Reis ◽  
Donald T. Weed ◽  
Nagy Elsayyad ◽  
Michael Samuels ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Population Based ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Cancer Rates
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